Search results for "FORMULATION"
showing 10 items of 265 documents
Simultaneous dissolution profiles of two drugs in pharmaceutical formulations by an FIA manifold
2002
Abstract This article deals with the simultaneous determination of dissolution profiles of two drugs with overlapped spectra, present in the same pharmaceutical formulation. The official procedure for the dissolution profile is adapted to the continuous-flow methodology; the dissolution vessel is connected to an FIA manifold, in which the sample aliquots from the dissolution vessel are treated in order to adjust to the suitable pH and dilution degree to be monitored. The resulting solution is injected into the carrier stream, an acetic acid–acetate buffer at pH 4.3 and forced to the flow-cell of the spectrophotometer. The simultaneous determination of both profiles is based on the first der…
Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.
2021
Abstract Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular matrix. To this aim, the co-assembly behaviour of a carboxylated variant of xyloglucan (CXG) with a peptide amphiphile (PA-H3) has been investigated to generate hierarchical constructs with tuneable molecular composition, structure, and properties. Transmission electron microscopy and circular dichroism at a low c…
Preclinical models for colonic absorption, application to controlled release formulation development.
2018
Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.
Direct Evaluation of Path Integrals
2001
Every time τ n is assigned a point y n . We now connect the individual points with a classical path y(τ). y(τ) is not necessarily the (on-shell trajectory) extremum of the classical action. It can be any path between τ n and τn−1 specified by the classical Lagrangian \(L(y,\dot{y},t).\)
A computational aeroelastic framework based on high-order structural models and high-fidelity aerodynamics
2023
A computational framework for high-fidelity static aeroelastic analysis is presented. Aeroelastic analysis traditionally employs a beam stick representation for the structure and potential, inviscid and irrotational flow assumptions for the aerodynamics. The unique contribution of this work is the introduction of a high-order structural formulation coupled with a high-fidelity method for the aerodynamics. In more details, the Carrera Unified Formulation coupled with the Finite Element Method is implemented to model geometrically complex composite, laminated structures as equivalent bi-dimensional plates. The open-source software SU2 is then used for the solution of the aerodynamic fields. T…
Continuous reformulations and heuristics for the Euclidean travelling salesperson problem
2008
We consider continuous reformulations of the Euclidean travelling salesperson problem (TSP), based on certain clustering problem formulations. These reformulations allow us to apply a generalisation with perturbations of the Weiszfeld algorithm in an attempt to find local approximate solutions to the Euclidean TSP.
A comparison of STARFM and an unmixing-based algorithm for Landsat and MODIS data fusion
2015
article i nfo The focus of the current study is to compare data fusion methods applied to sensors with medium- and high- spatial resolutions. Two documented methods are applied, the spatial and temporal adaptive reflectance fusion model (STARFM) and an unmixing-based method which proposes a Bayesian formulation to incorporate prior spectral information.Furthermore, thestrengths of both algorithms arecombined ina novel data fusionmethod: the Spatial and Temporal Reflectance Unmixing Model (STRUM). The potential of each method is demonstrated using simulation imagery and Landsat and MODIS imagery. The theoretical basis of the algorithms causes STARFM and STRUM to produce Landsat-like reflecta…
ViziQuer: A Visual Notation for RDF Data Analysis Queries
2019
Visual SPARQL query notations aim at easing the RDF data querying task. At the current state of the art there is still no generally accepted visual graph-based notation suitable to describe RDF data analysis queries that involve aggregation and subqueries. In this paper we present a visual diagram-centered notation for SPARQL select query formulation, capable to handle aggregate/statistics queries and hierarchic queries with subquery structure. The notation is supported by a web-based prototype tool. We present the notation examples, describe its syntax and semantics and describe studies with possible end users, involving both IT and medicine students.
Path Integral approach via Laplace’s method of integration for nonstationary response of nonlinear systems
2019
In this paper the nonstationary response of a class of nonlinear systems subject to broad-band stochastic excitations is examined. A version of the Path Integral (PI) approach is developed for determining the evolution of the response probability density function (PDF). Specifically, the PI approach, utilized for evaluating the response PDF in short time steps based on the Chapman–Kolmogorov equation, is here employed in conjunction with the Laplace’s method of integration. In this manner, an approximate analytical solution of the integral involved in this equation is obtained, thus circumventing the repetitive integrations generally required in the conventional numerical implementation of …
Anharmonicity deformation and curvature in supersymmetric potentials
1994
An algebraic description of the class of 1D supersymmetric shape invariant potentials is investigated in terms of the shape-invariant-potential (SIP) deformed algebra, the generators of which act both on the dynamical variable and on the parameters of the potentials. The phase space geometry associated with SIP's is studied by means of a coherent state (SIP-CS) path integral and the ray metric of the SIP-CS manifold. The anharmonicity of SIP's results in a inhomogeneous phase space manifold with one Killing vector and with a modified symplectic Kahler structure, and it induces a non constant curvature into the generalized phase space. Analogous results from the phase space geometry of someq…