6533b860fe1ef96bd12c3b2f
RESEARCH PRODUCT
Preclinical models for colonic absorption, application to controlled release formulation development.
Marival BermejoIsabel Lozoya-agulloIsabel González-álvarezMatilde Merino-sanjuánMarta González-álvarezsubject
ColonDrug Evaluation PreclinicalPharmaceutical ScienceAdministration Oral02 engineering and technologyPharmacology030226 pharmacology & pharmacyModels BiologicalDosage form03 medical and health sciences0302 clinical medicinemedicineOral routeAnimalsHumansIntestinal permeabilityChemistryGeneral Medicine021001 nanoscience & nanotechnologymedicine.diseaseControlled releaseColonic absorptionIntestinal AbsorptionPharmaceutical PreparationsControlled-Release FormulationsDelayed-Action PreparationsDrug DesignSystemic administration0210 nano-technologyBiotechnologydescription
Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-01 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V |