Search results for "FORS"
showing 10 items of 285 documents
Diffusion of Drone Journalism: the Case of Finland, 2011-2020
2020
This article details Finnish news organizations’ adoption of drones for journalistic purposes from 2011 to 2020. The theoretical starting point of the article is Rogers’ (1962) diffusion of innovations theory, which explains how new ideas and technologies spread in societies. The main empirical data for the study were derived from a phone survey conducted among the 80 most popular newspapers in Finland. The findings reveal that drone journalism in Finland has already diffused from a few pioneering organizations to a large number of newsrooms, including regional, mid-sized newspapers. Most of the newspapers are either using in-house drones, buying commissioned images, or using both strategie…
Le Istituzioni di Gaio e il Glücksstern di Niebuhr
2012
Sulla base della documentazione manoscritta, anche inedita, e di altre fonti si ripercorrono le vicende che portarono nel 1816 Barthold Georg Niebuhr a scoprire il palinsesto delle Istituzioni di Gaio nella Biblioteca Capitolare di Verona e si discute criticamente la casualità di tale scoperta.
Der ‚Glücksstern‘ Niebuhrs und die Institutionen des Gaius. Deutsch-italienische Wissenschaftspolitik im frühen 19. Jahrhundert, 2. erweiterte Auflage
2014
In diesem Buch ist die Geschichte der Wiederentdeckung des Palimpsests mit den Gaius-Institutionen durch Barthold Georg Niebuhr neu verhandelt. Die jüngst wiederbelebte These von einer „angekündigten Entdeckung“ wird in Frage gestellt. Das verzerrte Bild des Niebuhrschen Fundes in der Sicht dieser These ist kein Zufall. Es stellt sich vielmehr als später Nachklang wissenschaftlicher Querelen jener Zeit dar. Die These der „angekündigten Entdeckung“ erweist sich bei gründlicher Nachprüfung anhand der Quellen als spekulativ, der Fund ist als eigene Leistung Niebuhrs anzuerkennen. In dieser Abhandlung werden auch bislang unbeachtete oder missverstandene handschriftliche Dokumente textgetreu edi…
Mentoring of newly qualified teachers. A bilateral comparison between Germany and Finland
2017
Mentoring stellt in der Begleitung von in den Beruf einsteigenden Lehrpersonen eine international gängige Praxis dar. Ausgehend von theoretischen und empirisch fundierten Annahmen wird in diesem Beitrag der Ansatz der practice architectures genutzt, um Formen des Mentorings in Deutschland und Finnland im Hinblick auf länderspezifische Verständnisse vom Berufseinstieg von Lehrpersonen und deren Professionalisierung zu untersuchen. (DIPF/Orig.) Internationally, mentoring is a well-recognized practice in supporting newly qualified teachers. Based on theoretical and empirical understanding, this paper compares mentoring practices in two countries: Germany and Finland. The theoretical framework …
Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell pro…
2013
Abstract The beta3 adrenergic receptor (B3-AR) reportedly induces cell proliferation, but the signaling pathways that were proposed, involving either Gs or Gi coupling, remain controversial. To further investigate the role of G protein coupling in B3-AR induced proliferation, we stimulated primary human myometrial smooth muscle cells with SAR150640 (B3-AR agonist) in the absence or presence of variable G-protein inhibitors. Specific B3-AR stimulation led to an Erk1/2 induced proliferation. We observed that the proliferative effects of B3-AR require two Erk1/2 activation peaks (the first after 3 min, the second at 8 h). Erk1/2 activation at 3 min was mimicked by forskolin (adenylyl-cyclase a…
Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.
2003
Abstract The enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. Fifteen extracts from traditional Chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. Astragalus membranaceus, Forsythia suspensa and Poria cocos inhibited 5-lipoxygenase, with IC50 values of 141, 80 and 141 μg mL−1, respectively. The latter two species, along with Angelica dahurica and Angelica pubescens, also inhibited elastase (IC50 values of 80, 123, 68 and 93 μg mL−1, respectively), while A. pubescens, Atractylodes macrocephala, …
Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP
1995
Abstract The molecular mechanism of the synergistic platelet inhibition by activators of adenylate cyclase and guanylate cyclase in human platelets was investigated. The adenylate cyclase activators iloprost and prostaglandin E 1 and the guanylate cyclase activator 3-morpholino-synonimine (SIN-1) dose-dependently inhibited thrombin-induced aggregation of washed human platelets. Furthermore, SIN-1 at a concentration inhibiting platelet aggregation by only 10% shifted the IC 50 values of iloprost and prostaglandin E 1 by one order of magnitude to the left, indicating a synergistic action of adenylate cyclase and guanylate cyclase activators. Iloprost and prostaglandin E 1 dose-dependently ele…
Uniqueness of diffusion on domains with rough boundaries
2016
Let $\Omega$ be a domain in $\mathbf R^d$ and $h(\varphi)=\sum^d_{k,l=1}(\partial_k\varphi, c_{kl}\partial_l\varphi)$ a quadratic form on $L_2(\Omega)$ with domain $C_c^\infty(\Omega)$ where the $c_{kl}$ are real symmetric $L_\infty(\Omega)$-functions with $C(x)=(c_{kl}(x))>0$ for almost all $x\in \Omega$. Further assume there are $a, \delta>0$ such that $a^{-1}d_\Gamma^{\delta}\,I\le C\le a\,d_\Gamma^{\delta}\,I$ for $d_\Gamma\le 1$ where $d_\Gamma$ is the Euclidean distance to the boundary $\Gamma$ of $\Omega$. We assume that $\Gamma$ is Ahlfors $s$-regular and if $s$, the Hausdorff dimension of $\Gamma$, is larger or equal to $d-1$ we also assume a mild uniformity property for $\Omega$ i…
Decrease of mRNA levels and biosynthesis of sucrase-isomaltase but not dipeptidylpeptidase IV in forskolin or monensin-treated Caco-2 cells.
1991
International audience; Treatment for 48 h of differentiated, confluent Caco-2 cells with 2.5 10(-5) M forskolin or 10(-6) M monensin, which produces a significant decrease of the de novo biosynthesis of sucrase-isomaltase, does not change quantitatively the de novo biosynthesis of dipeptidylpeptidase IV. Western blot analysis and silver nitrate staining indicate that neither drug induces any modification in the steady state expression of these two brush border hydrolases. Northern blot analysis shows that the level of dipeptidylpeptidase IV mRNA does not change in treated as compared to control Caco-2 cells. In contrast, forskolin and monensin dramatically decrease the level of sucrase-iso…
Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of…
2004
The expression level of neuronal nitric oxide synthase (nNOS) can vary depending on the (patho)physiological conditions. Here we document a marked induction of nNOS mRNA, protein, and total NO production in response to dibutyryl cyclic AMP (db-cAMP) in human A673 neuroepithelial cells. However, the upregulation of nNOS was associated with a decreased level of production of bioactive NO and by an increase in the level of generation of reactive oxygen species (ROS). ROS production could be prevented by the NOS inhibitor L-NAME, suggesting nNOS itself is involved in ROS generation. Sepiapterin supplementation of db-cAMP-treated A673 cells could restore full bioactive NO production, most likely…