Search results for "FRAM"
showing 10 items of 2142 documents
Splice donor site mutation in the lysosomal neuraminidase gene causing exon skipping and complete loss of enzyme activity in a sialidosis patient.
2001
Sialidosis is a lysosomal storage disease caused by the deficiency of K K-N-acetylneuraminidase (NEU1; sialidase), the key enzyme for the intralysosomal catabolism of sialylated glycoconjugates. We have identified a homozygous transversion in the last intron (IVSE +1 Gs C) in neu1 of a sialidosis patient. Sequencing of the truncated cDNA revealed an alternatively spliced neu1 transcript which lacks the complete sequence of exon 5. Skipping of exon 5 leads to a frameshift and results in a premature termination codon. This is the first description of an intronic point mutation causing a complete deficiency of the lysosomal neuraminidase activity. fl 2001 Federation of Euro- pean Biochemical S…
Receptor protein-tyrosine phosphatases: origin of domains (catalytic domain, Ig-related domain, fibronectin type III module) based on the sequence of…
2001
Abstract Reversible tyrosine phosphorylation of proteins is one of the major regulatory physiological events in response to cell-cell- and cell-matrix contact in Metazoa. Previously it was documented that the tyrosine phosphorylating enzymes, the tyrosine kinases (TKs), are autapomorphic characters of Metazoa, including sponges. In this paper the tyrosine dephosphorylating enzymes, the protein-tyrosine phosphatases (PTPs), are studied which can be grouped into two subfamilies, the soluble PTPs and the receptor PTPs (RPTPs). PTPs are characterized by one PTPase domain which interestingly comprises sequence similarity to yeast PTPs. In contrast to the PTPs, the RPTPs – which have been found o…
Cloning and characterization of PRB1, a Candida albicans gene encoding a putative novel endoprotease B and factors affecting its expression
2002
Abstract Several cDNA fragments corresponding to transcripts differentially expressed under conditions that favor mycelial growth of Candida albicans were identified by the “differential display” technique. One of these was cloned and used as a probe to rescue the full gene from a genomic library of the fungus. The sequence identified a single, uninterrupted open reading frame of 1395 nucleotides encoding a putative protein of 465 residues and a theoretical molecular weight of 50.3 kDa, present in the genome as a single copy located at chromosome 2 in different strains. The gene product showed high homology with subtilisin-like proteases, mainly PRB1, the vacuolar B protease from Saccharomy…
Putative evolutionary origin of plasmids carrying the genes involved in leucine biosynthesis in Buchnera aphidicola (endosymbiont of aphids)
1997
An 8.5-kb plasmid encoding genes (leuABCD) involved in leucine biosynthesis and a small plasmid of 1.74 kb of yet unknown function were found in the intracellular symbiont, Buchnera aphidicola, of two divergent aphid species, Thelaxes suberi and Tetraneura caerulescens, respectively. The leuABCD-carrying plasmid (pBTs1) was amplified from total aphid DNA by inverse long PCR, using outwardly oriented oligonucleotide primers specific to leuA. The resulting 8.2-kb PCR fragment as well as the 1.74-kb plasmid (pBTc1) were cloned and sequenced. pBTs1 differed from a previously described B. aphidicola plasmid (pRPE) of the aphid Rhopalosiphum padi by the presence of a small heat shock gene (ibp) a…
Controlling the molecular diffusion in MOFs with the acidity of monocarboxylate modulators.
2021
The catalytic performance of metal-organic frameworks (MOFs) is related to their physicochemical properties, such as particle size, defect-chemistry and porosity, which synthetic control can be potentially achieved by coordination modulation. By combining PXRD, 1HNMR, FT-IR, N2 uptake measurements we have found insights that the different types of defects (missing linker or missing clusters consequence of the spatial distribution of missing linkers, and the combination of both) could be controlled by the type of modulator employed. We show that the molar percent of defects, either as missing linkers or as part of missing cluster defects, is related to the modulator’s acidity and subse…
Municipal budgetary framework and forecasting errors: The case of Moroccan municipalities
2017
International audience
FrameNet Resource Grammar Library for GF
2012
In this paper we present an ongoing research investigating the possibility and potential of integrating frame semantics, particularly FrameNet, in the Grammatical Framework (GF) application grammar development. An important component of GF is its Resource Grammar Library (RGL) that encapsulates the low-level linguistic knowledge about morphology and syntax of currently more than 20 languages facilitating rapid development of multilingual applications. In the ideal case, porting a GF application grammar to a new language would only require introducing the domain lexicon - translation equivalents that are interlinked via common abstract terms. While it is possible for a highly restricted CNL,…
Selective Change Driven Imaging: A Biomimetic Visual Sensing Strategy
2011
Selective Change Driven (SCD) Vision is a biologically inspired strategy for acquiring, transmitting and processing images that significantly speeds up image sensing. SCD vision is based on a new CMOS image sensor which delivers, ordered by the absolute magnitude of its change, the pixels that have changed after the last time they were read out. Moreover, the traditional full frame processing hardware and programming methodology has to be changed, as a part of this biomimetic approach, to a new processing paradigm based on pixel processing in a data flow manner, instead of full frame image processing.
Tecsis: Low-Cost Methodology To Distinguish Archaeological Findings
2006
The automatic or semi-automatic research of archaeological findings includes some methodologies and algorithms of the Computer Vision. Reconstruction of a scene is one of the key step to get the solution to that challenge. This paper will address a methodology to reconstruction underwater scenes with mosaicing techniques. The reconstruction of scene will be the video-mosaic of sea bottom landscapes starting from single video frames. The methodology is based on the evaluation of the optic °ow in between frames, and its motion estimation has been evaluated on the extracted features from the common areas of consecutive pairs frames. This approach carried out the motion model from a geometric p…
An agent-based system for maritime search and rescue operations
2010
Maritime search and rescue operations are critical missions involving personnel, boats, helicopter, aircrafts in a struggle against time often worsened by adversary sea and weather conditions. In such a context, telecommunication and in- formation systems may play a crucial role sometimes concurring to successfully accomplish the mission. In this paper we present an application able to localize the vessel who has launched a rescue request and to plan the most effective path for rescue assets. The application has been realised as a distributed and open multi-agent system deployed on rescue vehicles as well as on a land maritime stations of the Italian Coast Guard. The system is going to be t…