Search results for "FTO"

Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption

2012

Background: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective: To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods: Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associati…

The balancing act: How do moral norms and anticipated pride drive food waste/reduction behaviour?

2022

Food waste is a serious problem that impacts the environment and sustainability by increasing greenhouse gas emissions from landfills. Food waste also represents a social challenge because it raises serious concerns about food security. While acknowledging that households waste a great deal of food because they lack a proper routine for reusing leftovers and purchase more food than required, few studies have extensively examined the drivers of leftover reuse and over-ordering. We address this gap using the stimulus-organism-response paradigm. Moral norms and anticipated pride are conceptualised as stimuli that impact the organismic state of intentions against food waste and response in the …

Mucus and Cell-Penetrating Nanoparticles Embedded in Nano-into-Micro Formulations for Pulmonary Delivery of Ivacaftor in Patients with Cystic Fibrosis

2017

Here, mucus-penetrating nanoparticles (NPs) for pulmonary administration of ivacaftor in patients with cystic fibrosis (CF) were produced with the dual aim of enhancing ivacaftor delivery to the airway epithelial cells, by rapid diffusion through the mucus barrier, and at the same time, promoting ivacaftor lung cellular uptake. Pegylated and Tat-decorated fluorescent nanoparticles (FNPs) were produced by nanoprecipitation, starting from two synthetic copolymers, and showed nanometric sizes (∼70 nm), a slightly negative ζ potential, and high cytocompatibility toward human bronchial epithelium cells. After having showed the significant presence of poly(ethylene glycol) chains and Tat protein …

Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population

2012

Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population. Methods We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients (OHP) (n = 203) and elderly subjects (n = 1027) with high cardiovascular risk (HCR). Weight and height were directly measured. Education and physical activity (PA) were measured using questionnaires. Results The rs9939609 presented heterogeneous associations with BMI. In the GP, the minor A-allele was significantly associated wit…

Outdoor performance of north-facing multicrystalline modules in Southern Norway

2012

The present paper deals with reports on an outdoor performance evaluation of multicrystalline modules facing north in Southern Norway. The relevance of this study is mainly for building integrated systems where some of the facades are in a far from optimum position. The impact of shading on the photovoltaic modules' performance is also evaluated. A dedicated experimental set up has been created to study the PV modules performance under the above mentioned conditions. The results indicate significant power extraction from the PV modules even in the north facing direction. Effects of shadowing are also considered.

Hydrogen back-up power system with photovoltaic direct energy transfer regulation and interleaved boost for space applicattions

2012

This work details a power conditioning unit for photovoltaic/hydrogen based energy systems in space applications. The power conversion techniques applied are similar to the ones used on photovoltaic/battery space power systems. A direct energy transfer photovoltaic regulator is devised for feeding two outputs; the first output corresponds to the main unregulated battery bus and the second output sets a power path to feed an electrolyser. A modular fuel cell converter completes the system and operates when photovoltaic energy is not available or load demand exceeds the generated photovoltaic power, providing electrical power from a fuel cell. An ancillary battery, located in the main bus, di…

The FTOPSIS method to support FMECA analyses

2016

This paper proposes an approach based on multi-criteria decisional methods to manage the results derived from reliability analyses. In detail, this paper proposes ranking the failure modes of a system when analyzed with failure modes, effects and criticality analysis (FMECA) using the technique for order preference by similarity to ideal solutions (TOPSIS). To better manage the uncertainty of evaluations made under the differing criteria, the TOPSIS method is applied in its fuzzy version (FTOPSIS). When the method is applied to a case study, the results highlight the main possible critical faults and supply fundamental information to take into account during the scheduling of maintenance ac…

Latvijas Valsts Universitātes Zinātniskie Raksti. 25. sējums. Filoloģijas zinātnes : valodniecības rakstu krājums. 3A sērija

1958

Aftosi Ricorrente: caratteristiche cliniche e diagnosi differenziale

2011

Non disponibile

Performance assessment of a grid-connected mc-Si PV system made up of silicon material from different manufacturing routes

2013

Summarises the performance of an Elkem Solar photovoltaic (PV) system installed in the Sunbelt Region (between 35 North and 35 South) in Hyderabad, India, which has been fully operational since August 2012. The PV system consists of 28 multicrystalline silicon PV modules made from the standard Siemens process and from material produced by a metallurgical route - the Elkem Solar Silicon (ESS™) process. A comparative performance study of the ESS™ modules with respect to standard polysilicon has been carried out under the various climatic and solar radiation conditions at the location. The present study suggests that the ESS™ PV modules have a slightly better performance than standard polysili…