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RESEARCH PRODUCT

Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population

Ramon EstruchRamon EstruchJosé V. SorlíJosé V. SorlíPaula CarrascoPaula CarrascoJosé I. GonzálezJosé I. GonzálezMarisa GuillénMarisa GuillénDolores CorellaJose M. OrdovasJose M. OrdovasJose M. OrdovasCarolina Ortega-azorínCarolina Ortega-azorínOscar ColtellCarmen SaizCarmen Saiz

subject

Mediterranean climateMaleEndocrinology Diabetes and MetabolismMedicine (miscellaneous)MediterraneanBody Mass IndexGene FrequencyPolymorphism (computer science)Risk FactorsSurveys and QuestionnairesOdds RatioPrevalenceGeneticsAged 80 and overeducation.field_of_studyNutrition and DieteticsAnthropometryMiddle AgedPhenotypeEducational StatusFemaleCardiology and Cardiovascular MedicineFTOAdultmedicine.medical_specialtyAdolescentPopulationAlpha-Ketoglutarate-Dependent Dioxygenase FTOSingle-nucleotide polymorphismBiologyMotor ActivityPolymorphism Single NucleotideRisk AssessmentArticleEducational levelYoung AdultInternal medicinemedicineSNPHumansGenetic Predisposition to DiseaseObesityeducationAgedChi-Square DistributionPhysical activitynutritional and metabolic diseasesProteinsAnthropometrymedicine.diseaseObesityEndocrinologyLogistic ModelsSpainMultivariate AnalysisLinear ModelsBody mass index

description

Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population. Methods We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients (OHP) (n = 203) and elderly subjects (n = 1027) with high cardiovascular risk (HCR). Weight and height were directly measured. Education and physical activity (PA) were measured using questionnaires. Results The rs9939609 presented heterogeneous associations with BMI. In the GP, the minor A-allele was significantly associated with greater BMI, following a co-dominant pattern (P = 0.009), whereas in the OHP this association was recessive (P = 0.004). Conversely, we did not find a significant association with BMI in the HCR group (P < 0.596). In the GP we found a significant interaction between the FTO SNP and education (P = 0.048). In the stratified analysis, no association of the FTO SNP with greater BMI in university subjects was detected (P = 0.786), whereas the association was observed in non-university subjects (P = 0.001). The FTO × education interaction (P = 0.020) was also observed in determining obesity risk in the GP. A-allele carriers had a greater risk of being obese only if they had no university education (OR: 1.56; 95%CI: 1.09–2.23 for TA and OR: 2.01; 95%CI: 1.27–3.26 for AA subjects). The interaction of the FTO with education remained significant even after adjustment for PA. This work was supported by grants from the Ministerio de Ciencia e Innovacio´n (CIBER CB06/03/0035, RD07/0067/ 0006, PI06-1326, PI07-0954, PI08-90002 and SAF-09- 12304), the Generalitat Valenciana (GVACOMP2010-181, BEST2010-211, BEST2010-032) and the National Heart, Lung, and Blood Institute grants HL-54776, National Institute of Diabetes and Digestive and Kidney Diseases, Grant Number DK075030 and by contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research.

yearjournalcountryeditionlanguage
2012-01-01
10.1016/j.numecd.2010.10.006