Search results for "Farm"
showing 10 items of 3554 documents
2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action
2013
Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
Synthesis and biological evaluation of some new 2-cinnamidobenzamides as potential antagonist of the HDM2-p53 protein-protein interactions
2008
Revisiting agricultural modernisation: Interconnected farming practices driving rural development at the farm level
2019
Abstract Rural development related to agriculture can roughly be divided into two trajectories: 1) agri-industrial development or modernisation, and 2) multifunctional or even post-productivist rural development. The role of these trajectories varies in different rural settings, with different emphases on agricultural production and its conduct. At the farm level, the trajectories evolve from existing farming practices and their connections, which enable or disable different kinds of development. However, the connections through which changes in agricultural production practices contribute to different rural development trajectories deserve further scrutiny. This is addressed with the help …
2. tipa cukura diabēta ārstēšanai paredzēto medikamentu aprite aptiekā un ar to lietošanu saistītās blakusparādības
2020
2. tipa cukura diabēts ir viena no izplatītākajām slimībām pasaulē, izraisot mikrovaskulāras un makrovaskulāras komplikācijas. Slimība ir hroniska un progresē pēc 45 gadu vecuma saistībā ar nepilnvērtīgu uzturu un mazkustīgu dzīvesveidu. Katru gadu 2. tipa cukura diabēta pacientu skaits pieaug un līdz ar to arī antidiabētisko līdzekļu patēriņš. Darba mērķis bija izpētīt 2. tipa cukura diabēta ārstēšanai paredzēto medikamentu apriti aptiekā un ar antidiabētisko medikamentu lietošanu saistītās blakusparādības. Pētījuma rezultāti liecina, ka 2. tipa cukura diabēta ārstēšanai vairāk tiek izrakstīti perorālie antidiabētiskie medikamenti, no kuriem populārākā antidiabētisko medikamentu grupas zāļ…
D vitamīna deficīts Latvijā salīdzinājumā ar citām valstīm un biežāk pielietotie principi tā novēršanai
2019
Vitamīna D nepietiekamība ir plaši izplatīta visā pasaulē. Veiktajā pētījumā tika analizētas „E.Gulbja laboratorijā” 02.01.2014.-31.12.2018. veikto vitamīna D asins analīžu rezultāti, un aptiekas klientu un ārstu anketēšanā iegūtā informācija. Pētījuma rezultāti liecina, ka 64% no visām veiktajām analīzēm tiek konstatēts vitamīna D trūkums. Novērošanas periodā konstatētais vidējais D vitamīna līmenis bija 27,5 ng/mL, kas, salīdzinājumā ar citām Eiropas valstīm, ir tuvu pietiekama līmeņa robežai. Vitamīna D līmeņa atjaunošanai iedzīvotāji 58,4% (n=59) veic pastaigas ārpus telpām, 55,4% (n=56) uzturā lieto ar vitamīnu D bagātu pārtiku, bet 36,6% (n=37) lieto vitamīnu D saturošus medikamentus …
NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DI PATOLOGIE EMATOLOGICHE
2019
La presente invenzione si riferisce al campo di nuove molecole tetracicliche, aventi un sistema tetraciclico, e loro impiego come medicamenti di patologie ematologiche in particolare per il trattamento della leucemia mieloide acuta (AML) in pazienti emizigoti FLT3/ITD resistenti alle terapie convenzionali.
SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,5-BIS(3'-INDOLYL)-FURANS AND 3,5-BIS(3'-INDOLIY)-ISOXAZOLES, NORTOPSENTIN ANALOGUES
2010
Abstract A series of novel 2,5-bis(3′-indolyl)furans and 3,5-bis(3′-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC50 values of 17.4 μg/mL (3a) and 20.5 μg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines.
Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues
2009
Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.
SYNTHESIS OF 3-(2-PHENYL-1,3-THIAZOL-4-YL)-1H-INDOLES, NEW DERIVATIVES WITH POTENTIAL ANTINEOPLASTIC ACTIVITY
2008
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 3-AMINO-N-PHENYL-1H-INDAZOLE-1-CARBOXAMIDES
2010
Recently our research group has reported the synthesis of some 3-amino-N-phenyl-1H-indazole-1-carboxamides able to inhibit at low micromolar concentrations the cell growth of many neoplastic cell lines. The above compounds are unsubstituted in the indazole nucleus and this gives the hope to obtain more active compounds if appropriate substituents are beared by the above nucleus. So, several new N-phenyl-1H-indazole-1-carboxamides 1c-h and 4l,m were prepared by reacting phenyl isocyanates 3a,b with 3-amino-1H-indazoles 2c,e,g, or 1H-indazole 2l respectively. Chemical trasformations of compounds 1a,b and 1g,h gave 3-acetamido-N-phenyl-1H-indazole-1-carboxamides 5a,b, and 3,5-diamino-N-phenyl-…