Search results for "Farm"

showing 10 items of 3554 documents

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

siRNA deliveryRNase PCellPharmaceutical Science02 engineering and technology010402 general chemistry01 natural sciencesArticleAnalytical Chemistrylcsh:QD241-441EGF; inulin; PEG; siRNA delivery; targeting; tumourlcsh:Organic chemistryEpidermal growth factorNeoplasmsDrug DiscoveryPEG ratioZeta potentialmedicineCopolymerHumansDoxorubicinPhysical and Theoretical ChemistryRNA Small InterferingtargetingEGFDrug CarriersinulinChemistrytumourOrganic ChemistryTransfection021001 nanoscience & nanotechnologyPEG0104 chemical sciencesNanostructuresmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoChemistry (miscellaneous)BiophysicsMCF-7 CellsMolecular Medicine0210 nano-technologymedicine.drugMolecules (Basel, Switzerland)
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Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015

A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…

siRNA deliverymicrowavespermineSettore CHIM/09 - Farmaceutico Tecnologico Applicativopolyplexnucleic acid based drugsInulin; microwave; nucleic acid based drugs; polyplex; siRNA delivery; spermineInulinInulin microwave nucleic acid based drugs polyplex siRNA delivery spermine
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Zakorzenienie gospodarstw rolnych w lokalnych (regionalnych) systemach biobiznesu – uwarunkowania instytucjonalne w województwie opolskim

2016

Celem opracowania jest wskazanie na rolę instytucji w kreowaniu lokalnych (regionalnych) biobiznesów. Lokalne biobiznesy opierają się na unikatowym wykorzystaniu zarówno standardowych, jak i specyficznych zasobów terytoriów, w których są zakładane. Analizę przeprowadzono z wykorzystaniem trzech wymiarów transformacji europejskiego modelu rolnictwa: regulacji środowiskowych, dyfuzji wiedzy i informacji oraz powiązań międzyorganizacyjnych i społecznych. Na podstawie przeprowadzonych badań ankietowych zidentyfikowano stopień zakorzenienia instytucji zarządzających powstaniem biogospodarki w sieciach społecznych użytkowników towarowych gospodarstw rolnych w województwie opolskim. Praca ma chara…

sieciowe struktury regulacyjneagricultural farmsustainable developmentinteligentna specjalizacja regionuintelligent specialization of regionsnetwork-based regulatory structureszrównoważony rozwójbio-economygospodarstwo rolnebiogospodarkaRoczniki Naukowe Stowarzyszenia Ekonomistów Rolnictwa i Agrobiznesu
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El “Dialogus” (1589) del paracelsista Llorenç Coçar y la Cátedra de medicamentos químicos de la Universidad de Valencia (1591)

1977

El Dialogus (1589) del paracelsista Llorenç Coçar y la cátedra de medicamentos químicos de la Universidad de Valencia (1591). La fundación de la cátedra de medicamentos químicos de Llorenç Coçar. Dialogus veros medicinae fontes indicans. //. El Dialogus (1589) del paracelsista Llorenç Coçar i la càtedra de medicaments químics de la Universitat de València (1591). La fundació de la càtedra de medicaments químics de Llorenç Coçar. Dialogus veros medicinae fonts indicans.

siglo XVImedicamentossegle XVImedicamentsUNESCO::HISTORIA::Historia por especialidades::Historia de la medicinallorenç coçarhistòriahistoriaUNESCO::CIENCIAS MÉDICAS ::Farmacologíamedicinadialogus
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UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS

2015

In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.

silica quantum dots cells hyaluronic acidSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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DELIVERY DI SOSTANZE ATTIVE DEL SISTEMA NERVOSO CENTRALE MEDIANTE PROFARMACI O SISTEMI PARTICELLARI

2012

sistemi particellariSettore CHIM/09 - Farmaceutico Tecnologico Applicativoprofarmaci
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Analysis of the molecular mechanisms that mediate the therapeutic actions of glucocorticoids in skin

2017

Tesis doctoral 189 páginas, 53 figuras, 1 tabla como material suplementario

skinPiel -- Enfermedades -- FarmacoterapiaUNESCO::CIENCIAS DE LA VIDAglucocorticoid receptorGlucocorticoides -- Uso terapeúticokeratinocytegilzzfp36klf4mouse:CIENCIAS DE LA VIDA [UNESCO]
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Radioaktīvo un smago metālu antidota jauna analoga izstrāde

2021

Pasaulē pieaug radioaktivitātes izmantošanas apjomi kā medicīnā, tā enerģijas ražošanā un šī sfēra saistās ar zināmiem riskiem, jo reti, taču regulāri notiek kodolincidenti. Tas ir iemesls veidot valsts rezerves, kurās ir antidoti iedzīvotāju pasargāšanai kodolincidentu gadījumā. Darba mērķis ir izstrādāt jaunu un efektīvāku dzelzs ferocianīda sintēzes shēmu salīdzinot ar šobrīd izmantotajām metodēm. Mērķa sasniegšanai tika optimizēta dzelzs ferocianīda sintēze izmantojot specifiskus sintēzes apstākļus, tai skaitā, specifisku reaģentu padošanas mehānismu, aktīvu maisīšanu, sintēzi ultraskaņas vannā un nesēja klātesamību, lai iegūtu iespējami augstvērtīgāku dzelzs ferocianīdu ar iespējami ma…

smagie metāliFarmācijaantidotsferocianīdsradioaktīvais piesārņojumscianoferāts
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Pacientu informētība par ērču encefalītu un profilaktisko terapijas iespējām Latvijā

2021

Ērču encefalīts (ĒE) mūsdienās ir plaši pazīstama vīrusinfekcija. ĒE ir infekcijas slimība, ko cilvēkam pārnes Ixodes tipa ērces. Latvijā par endēmiskiem ir atzīti 22 novadi, tādēļ ir liels risks inficēties ar ĒE. Līdz ar to iedzīvotāju informētība par ĒE un profilaktisko terapijas iespējām ir aktuāla un svarīga. Darba mērķis bija sociālās aptaujas ietvaros uzzināt un novērtēt Latvijas iedzīvotāju informētību par ĒE vīrusinfekciju un to profilaktisko terapijas iespējām Latvijā. Iegūtie dati reprezentēja, ka kopējais Latvijas iedzīvotāju informētības līmenis par ĒE ir augsts, un cilvēkiem ir pieejama informācija par profilaktisko terapiju iespējām. Tika noskaidrots, ka 146 aptaujāto responde…

sociālā aptaujaērču encefalītsvakcinācijaFarmācijainformētība
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Effective Practices in Mitigating Soil Erosion from Fields

2017

Soil erosion by water is a natural process that cannot be avoided. Soil erosion depends on many factors, and a distinction should be made between humanly unchangeable (e.g., rainfall) and modifiable (e.g., length of the field) soil erosion factors. Soil erosion has both on-site and off-site effects. Soil conservation tries to combine modifiable factors so as to maintain erosion in an area of interest to an acceptable level. Strategies to control soil erosion have to be adapted to the desired land use. Knowledge of soil loss tolerance, T, i.e., the maximum admissible erosion from a given field, allows technicians or farmers to establish whether soil conservation practices need to be applied …

soil erosion soil loss tolerance on-site and off-site erosion impacts soil conservation burned areas erosion modeling for soil conservationSoil biodiversityAgroforestrycomplex mixturesSoil managementNo-till farmingEnvironmental protectionSoil functionsSoil retrogression and degradationEnvironmental scienceSettore AGR/08 - Idraulica Agraria E Sistemazioni Idraulico-ForestaliDryland salinitySoil conservationSurface runoff
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