Search results for "Farm"
showing 10 items of 3554 documents
La transversalidad de los trastornos del comportamiento alimentario: un reto para los cuidados de salud
2004
Los trastornos de la conducta alimentaria son una causa importante de morbilidad física y psicosocial en jóvenes adolescentes y en mujeres adultas jóvenes y, aunque en distinto grado, afectan a personas tanto de países desarrollados como de países en vías de desarrollo. En este trabajo se expone como ejemplo la situación España y Perú. Se trata de un problema de origen multicausal que es transversal a condiciones socioeconómicas y clase social y en la actualidad, es la teoría del factor sociocultural la que mejor soporta la interpretación de los datos disponibles. En este contexto, el rol y la responsabilidad que compete a Enfermería y a otros profesionales de la salud tiene grandes dimensi…
Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial ac…
2012
Anthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vu…
Aspects of soil phenolic matter (SPM): An explorative investigation in agricultural, agroforestry, and wood ecosystems
2014
Abstract This paper assesses the distribution of soil phenolic matter (SPM) in soil environments from a pedological perspective, with particular emphasis on soil horizonation and its involvement in pedogenic processes. The study was conducted on 15 soil profiles (Andosols, Calcisols, Cambisols, Lixisols, Phaeozems, Podzols, Umbrisols) covering five distinct ecosystems. Although the ecosystems were virtually homogeneous in and of themselves, they represented strongly contrasting climates, geolithology and morphology, land use and vegetation cover (intensive agriculture, chestnut grove, alpine pasture, woody reforestations, and natural woods). Three main SPM fractions were categorised: (i) “t…
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
2004
Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
Eight-Membered Rings With Two Heteroatoms 1,3
2022
Eight-membered rings with two heteroatoms in a 1,3-relationship, namely 1,3-diazocine, 2H-1,3-oxazocine, 2H-1,3-thiazocine, 4H-1,3-dioxocin, 4H-1,3-oxathiocin, and 4H-1,3-dithiocin, are discussed in this chapter, that covers the literature from 2007 to October 2020 (SciFindern search) and reports the chemistry of uncondensed derivatives, heterocines fused to carbocycles and heterocycles, as well as bridged heterocines. Among eight-membered 1,3-diheterocines, 1,3-diazocines and 1,3-oxazocines are the two largest classes, based on the number of publications, mostly due to the studies of the synthesis of these cyclic systems, their pharmacological properties and/or their important industrial a…
Chemical composition of the essential oil from Thapsia garganica L. (Apiaceae) grown wild in Sicily and its antimicrobial activity.
2015
In this study, the chemical composition of the essential oil from flowers and leaves of Thapsia garganica L. collected in Sicily was evaluated by GC and GC-MS. The main components of T. garganica flower oil (T.f.) were chamazulene (58.3%), humulene oxide II (9.0%), tricosane (8.2%) and pentacosane (8.2%). Also the oil from leaves (T.l.) was characterised by high content of chamazulene (49.2%). Other abundant metabolites were 1,4-dimethylazulene (18.5%), (E)-phytol (6.3%) and neophytadiene (5.1%). The comparison with other studied oils of genus Thapsia is discussed. Antimicrobial activity against several micro-organisms, including some ones infesting historical art craft, was also determined.
Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance
2018
Abstract Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens responsible for serious chronic infections. In the last decade many efforts have been made to identify new agents able to modulate bacterial biofilm life cycle, and many compounds have shown interesting activities in inhibiting biofilm formation or in dispersing pre-formed biofilms. However, only a few of these compounds were tested using in vivo models for their clinical significance. Contrary to conventional antibiotics, most of the anti-biofilm compounds act as anti-virulence agents as they do not affect bacterial growth. I…
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
2022
: In order to develop novel inhibitors of the bacterial deacetylase LpxC bearing a substituent to target the UDP binding site of the enzyme, a series of aldotetronic acid-based hydroxamic acids was accessed in chiral pool syntheses starting from 4,6-O-benzylidene-d-glucose and l-arabinitol. The synthesized hydroxamic acids were tested for LpxC inhibitory activity in vitro, revealing benzyl ether 17a ((2S,3S)-4-(benzyloxy)-N,3-dihydroxy-2-[(4-{[4-(morpholinomethyl)phenyl]ethynyl}benzyl)oxy]butanamide) as the most potent LpxC inhibitor. This compound was additionally tested for antibacterial activity against a panel of clinically relevant Gram-negative bacteria, bacterial uptake, and suscepti…
Antibakteriālo līdzekļu patēriņš ambulatorajā un stacionārajā praksē Latvijā
2017
Antibakteriālo līdzekļu lietošana ir efektīvs veids kā ārstēt infekciju saslimšanas. Lielākā problēma mūsdienās, kas saistīta ar antibakteriālajiem preparātiem, ir patogēno mikroorganismu rezistence pret tiem. Diemžēl, rezistences attīstīšanās apsteidz jaunu antibakteriālo līdzekļu ienākšanu medicīnas nozarē. Bakalaura darba mērķis bija noskaidrot antibakteriālo līdzekļu izrakstīšanas un lietošanas principus Latvijā ambulatorajā un stacionārajā sektorā, kā arī novērot antibakteriālo līdzekļu patēriņa tendenci kāda veidojusies valstī 10 gadu laikā, salīdzinoši ar citām Eiropas valstīm. Pētījumā noskaidrots, ka visizplatītākā antibakteriālo līdzekļu klase Latvijā ir beta laktāmi (J01C). Latvi…