Search results for "Farm"
showing 10 items of 3554 documents
NANOTECHNOLOGIES FOR BIOMEDICAL APLICATIONS
2010
SOLUBLE AND WATER-SWELLABLE POLYAMINOACIDIC CONSTRUCTS FOR DRUG DELIVERY
2004
PREPARAZIONE DI NUOVI SISTEMI POLIMERICI PER IL DRUG DELIVERY
2013
Farmakognozija, 1. Vispārīgā daļa
1940
Praktiskā piensaimniecība
1928
Saturs: I. Pienalopu izvēle, izkopšana un apkopšana. Piens, krējums un tā pārstrādāšana sviestā. II. Sierniecība. III. Piensaimniecības mašīnas.
Darba vides riska faktori aptiekā strādājošajiem farmaceitiem un preventīvie pasākumi
2016
Mūsdienās īpaša uzmanība tiek veltīta darba vides riskiem un darbinieku aizsardzībai, lai tiktu garantēta darbinieka drošība darbā un veselība ilgtermiņā, tāpēc autores maģistra darbs ir par darba vides riskiem un to ietekmi uz aptiekā strādājošajiem farmaceitiem. Darbs sastāv no trim daļām: 1.Literatūras analīze; 2.Materiālu un metodes; 3.Rezultāti un diskusija. Darba mērķis: analizēt literatūru par farmaceitu darba vides riskiem un izanalizēt iegūtos aptaujas datus izmantojot Somijas 5 baļļu metodi un Ātrās ekspozīcijas kontroles metodi, lai varētu novērtēt, vai farmaceitā darbā ir darba vides riski un kuri riski farmaceita darbā ir visbūtiskākie. Darba rezultātos atspoguļotas un analizēt…
Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale…
2021
BACKGROUND: The European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated, widely used tool developed to score the clinical benefit from cancer medicines reported in clinical trials. ESMO-MCBS scores assume valid research methodologies and quality trial implementation. Studies incorporating flawed design, implementation, or data analysis may generate outcomes that exaggerate true benefit and are not generalisable. Failure to either indicate or penalise studies with bias undermines the intention and diminishes the integrity of ESMO-MCBS scores. This review aimed to evaluate the adequacy of the ESMO-MCBS to address bias generated by flawed design, im…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with…
2020
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinetic (PBPK) models integrate all available information on gastro-intestinal system with drug and formulation data to predict oral drug absorption. The latter together with in vitro-in vivo extrapolation and other preclinical data on drug disposition can be used to predict plasma concentration-time profiles in silico. Despite recent successes of PBPK in many areas of drug development, an improvement in their utility for evaluating oral absorption i…
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
DNA-binding of nickel(II), copper(II) and zinc(II) complexes: structure-affinity relationships
2013
Abstract Nickel(II), copper(II) and zinc(II) complexes with the same ligands normally display analogous coordination geometry and binding mode toward DNA. However, although qualitatively alike in structure and properties, different DNA-binding ability has often been observed. This review surveys the most recent examples of binding of the three metal ions complexed with monodentate and chelating bidentate to tetradentate ligands to DNA. An attempt has also been made to rationalize the observed trend in the values of the intrinsic DNA-binding constant, Kb, in terms of structural and chemical features.