Search results for "Farm"

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-me…

2014

We synthesized a series of serum-stable covalently linked drugs derived from 3'-C-methyladenosine (3'-Me-Ado) and valproic acid (VPA), which are ribonucleotide reductase (RR) and histone deacetylase (HDAC) inhibitors, respectively. While the combination of free VPA and 3'-Me-Ado resulted in a clear synergistic apoptotic effect, the conjugates had lost their HDAC inhibitory effect as well as the corresponding apoptotic activity. Two of the analogs, 2',5'-bis-O-valproyl-3'-C-methyladenosine (A160) and 5'-O-valproyl-3'-C-methyladenosine (A167), showed promising cytotoxic activities against human hematological and solid cancer cell lines. A167 was less potent than A160 but had interesting featu…

Design and Synthesis of new Inhibitors of Carcinogenic Processes

2011

Design, synthesis and biological evaluation of new anticancer drugs: FGFR inhibitors

2021

Fibroblast growth factor receptors (FGFRs) constitute a family of tyrosine kinases receptors (RTKs) that exert pivotal physiological functions in human embryonic and adult tissues. Hyperactivated FGFR signaling drives tumorigenesis in multiple cancer types, including lung and brain cancers. Great effort has been laid on the development of new compounds that specifically target the FGFR axis. However, cancer cell- based and microenvironmental resistance mechanisms against FGFR inhibitors often arise and are currently poorly understood. Furthermore, FGFR-targeted therapy often presents different side effects, e due to the broad biological spectrum of the FGFR signaling axis as well as to its …

Prenatal diazepam exposure alters neurosteroid modulation of NMDA receptors regulating noradrenaline release from rat hippocampus

2002

Fabrication of silver nanoparticles by a diethylene triamine-hyaluronic acid derivative and use as antibacterial coating

2022

In this work a synthetic protocol for the functionalization of hyaluronic acid with diethylenetriamine (DETA) was standardized. HA-DETA derivatives were characterized by NMR and proton carbon correlation analysis HSQC and HMBC to confirm chemical structure. A selected derivative was used to set up a green fabrication procedure for HA-DETA capped silver nanoparticles with the aim to achieve a polymeric based coating with potential application in the treatment of medical devices associated infections. Data from UV-visible spectroscopy, electron scanning and transmission microscope (STEM), photoelectric spectroscopy (XPS) and rheological characterization were combined to characterize the HA-DE…

Frecuencia del consumo de drogas legales: Diferencias de edad en la adolescencia

2007

El consumo de drogas es especialmente relevante por sus efectos negativos sobre la salud psicofísica y el funcionamiento social de los jóvenes. El objetivo de este estudio fue analizar las diferencias de edad respecto a las frecuencias de consumo de alcohol y tabaco en una muestra de 354 escolares (50.85% varones) de 12 a 18 años (M = 14.66; DT = 1.08) que cumplimentaron el Questionnarie about Consume of Alcohol and Tobacco (TNT). Los resultados muestran que el 82.4% de los adolescentes ha consumido bebidas alcohólicas en alguna ocasión y el 25.6% es consumidor actualmente. Respecto al consumo de tabaco, el 40.4% de estudiantes afirma haber fumado en alguna ocasión, siendo consumidores actu…

The contribution of geographical certification programs to farm income and rural economies: The case of Pecorino Siciliano PDO

2021

This study attempts to measure the capacity of the EU geographical certification scheme to positively influence the price of certified products and the incomes of their producers. A comparison of the economic results of two cheese-producing dairy farm enterprises with different business strategies and locations within the Sicilian hinterlands is performed in order to determine the transformation value of each dairy’s sheep milk into pecorino cheese (with and without the Protected Designation of Origin, or PDO, certification) and the related joint products (ricotta). The economic convenience of the total transformation of sheep milk into Pecorino Siciliano PDO and ricotta is also appraised. …

Hippocampal reversible lesions in a case of transient global amnesia

2018

We report the case of 55-year-old man that after an emotional stress showed retrograde and anterograde amnesia with impairment of orientation in space and time but undisturbed consciousness. A neurological examination excluded other neurological signs or symptoms. The amnesic syndrome resolved spontaneously within 24 hours and the hypothesis of transient global amnesia was placed. Brain CT scan and conventional MRI sequences did not show any relevant pathological findings but diffusion-weighted imaging (DWI) showed two millimetric bright spot of restricted diffusion in the right hippocampus; in a brain MRI follow-up those findings were no more appreciable. The diagnosis of transient global …

Study of Reactivity in the 1,3-Dipolar Cycloaddition Reactions Leading to New Triazolopyrrolopyrazine Ring Systems

2010

The influence of the structural symmetry of the 2-pi double-reactive-sites component in the 1,3-dipolar cycloaddition reactions, involving nitrilimines as dipoles, was investigated. the experimental data showed that the loss of the symmetry leads to the formation of the monocycloadduct in good yields.

ELABORAZIONE RICHIESTA MOTIVATA DI TOSSINA BOTULINICA DI TIPO A, PRESSO IL P.O. SAN GIOVANNI DI DIO ASP AG

2014

Introduzione. La distonia è un disturbo associato ad anomalie nel movimento e nella postura causato da contrazioni muscolari involontarie. Esistono tre tipi di classificazione sulla base della: distribuzione anatomica(focale, segmentale, o generalizzata), età di insorgenza dei sintomi (giovanile o adulta esordio) ed eziologia, primaria, secondaria, o sintomatica.Dal mese di marzo 2014 attraverso l’ambulatorio dell’U.O. MedicinaFisica e Riabilitativa del P.O. di Ag è possibile attuare il trattamento con la tossina botulinica ai pazienti candidati. Materiali e metodi. È stata fatta condotta una ricognizione bibliografica attraverso PubMed e la position paper sulla tossina botulinica della Soc…