Search results for "FasR"

showing 2 items of 2 documents

Fluency and rule breaking behaviour in the frontal cortex

2020

Design (DF) and phonemic fluency tests (FAS; D-KEFS, 2001) are commonly used to investigate voluntary generation. Despite this, several important issues remain poorly investigated. In a sizeable sample of patients with focal left or right frontal lesion we established that voluntary generation performance cannot be accounted for by fluid intelligence. For DF we found patients performed significantly worse than healthy controls (HC) only on the switch condition. However, no significant difference between left and right frontal patients was found. In contrast, left frontal patients were significantly impaired when compared with HC and right frontal patients on FAS. These lateralization findin…

MaleLIFG Left Inferior Frontal GyrusRAPM Raven's Advanced Progressive MatricesIntelligenceLMFG Left Middle Frontal GyrusLF Left frontalAudiologyCorpus callosumCVA cerebrovascular accidentATR Anterior thalamic radiationExecutive FunctionBehavioral NeurosciencePFC prefrontal cortex0302 clinical medicineVerbal fluency testHC healthy controls10. No inequalityPrefrontal cortexLanguageFASRB Phonemic Fluency Rule Breakfluid intelligenceAged 80 and overfunctionsBrain Diseasesprefrontal cortexBrain Neoplasms05 social sciencesSuperior longitudinal fasciculusGNT Graded Naming TestMiddle AgedStrokemedicine.anatomical_structurePLSM Parcel-based Lesion Symptom MappingDF Design FluencyFluid Intelligence Parcel Based Lesion Symptom Mapping tract-wise statistical analysisFemalemedicine.symptomPsychologyAdultmedicine.medical_specialtyAdolescentCognitive NeuroscienceBrain AbscessExperimental and Cognitive PsychologyGrey matterrule break errorsArticle050105 experimental psychologyLateralization of brain functionLesionWhite matterYoung Adult03 medical and health sciencesexecutivestatistical analysismedicineHumans0501 psychology and cognitive sciencesAgedParcel based lesion symptom mapping tract-wise statistical analysisSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicaphonemic and design fluencyRL Right lesionparcel based lesion symptom mapping tractwiseLL left lesionIQ Intelligence QuotientVLSM Voxel-based lesion symptom mappingrule break errorNART National Adult Reading TestPsychomotor PerformanceTSA Tract-wise Statistical Analysis030217 neurology & neurosurgeryNeuropsychologia
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Triclosan induces Fas receptor-dependent apoptosis in mouse neocortical neurons in vitro

2014

Triclosan (TCS) is a commonly used antimicrobial agent in personal care and sanitizing products, as well as in household items. Numerous studies have demonstrated the presence of TCS in various human tissues. Several studies have reported the accumulation of TCS in fish and human brain tissue. The aim of the present study was to investigate the effect of TCS on apoptosis in mouse neocortical neurons after 7 days of culture in vitro following 3, 6 and 24 h of exposure. To explore the mechanism underlying the effects of TCS in neurons, we studied the activation and protein expression of the Fas receptor (FasR) and caspase- 8, caspase-9 and caspase-3, as well as DNA fragmentation in TCS-treate…

Time FactorsExtrinsic apoptotic signaling pathwayApoptosisNeocortexDNA fragmentation.DNA FragmentationCaspase 8caspase-8FasRMicePregnancyAnimalsfas ReceptorFADDEnzyme InhibitorsCells CulturedNeuronsDose-Response Relationship DrugL-Lactate DehydrogenasebiologyGeneral NeurosciencefungiEmbryo MammalianStaurosporineFas receptorApoptotic bodyTriclosanIn vitroCell biologyBiochemistryApoptosisCaspasesbiology.proteinFatty Acid Synthesis InhibitorsDNA fragmentationFemaleNeuroscience
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