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RESEARCH PRODUCT
Fluency and rule breaking behaviour in the frontal cortex
Lisa CipolottiPascal MolenberghsJuan DominguezDaniela SmirniTim ShalliceEdgar ChanTianbo XuNicola Smithsubject
MaleLIFG Left Inferior Frontal GyrusRAPM Raven's Advanced Progressive MatricesIntelligenceLMFG Left Middle Frontal GyrusLF Left frontalAudiologyCorpus callosumCVA cerebrovascular accidentATR Anterior thalamic radiationExecutive FunctionBehavioral NeurosciencePFC prefrontal cortex0302 clinical medicineVerbal fluency testHC healthy controls10. No inequalityPrefrontal cortexLanguageFASRB Phonemic Fluency Rule Breakfluid intelligenceAged 80 and overfunctionsBrain Diseasesprefrontal cortexBrain Neoplasms05 social sciencesSuperior longitudinal fasciculusGNT Graded Naming TestMiddle AgedStrokemedicine.anatomical_structurePLSM Parcel-based Lesion Symptom MappingDF Design FluencyFluid Intelligence Parcel Based Lesion Symptom Mapping tract-wise statistical analysisFemalemedicine.symptomPsychologyAdultmedicine.medical_specialtyAdolescentCognitive NeuroscienceBrain AbscessExperimental and Cognitive PsychologyGrey matterrule break errorsArticle050105 experimental psychologyLateralization of brain functionLesionWhite matterYoung Adult03 medical and health sciencesexecutivestatistical analysismedicineHumans0501 psychology and cognitive sciencesAgedParcel based lesion symptom mapping tract-wise statistical analysisSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicaphonemic and design fluencyRL Right lesionparcel based lesion symptom mapping tractwiseLL left lesionIQ Intelligence QuotientVLSM Voxel-based lesion symptom mappingrule break errorNART National Adult Reading TestPsychomotor PerformanceTSA Tract-wise Statistical Analysis030217 neurology & neurosurgerydescription
Design (DF) and phonemic fluency tests (FAS; D-KEFS, 2001) are commonly used to investigate voluntary generation. Despite this, several important issues remain poorly investigated. In a sizeable sample of patients with focal left or right frontal lesion we established that voluntary generation performance cannot be accounted for by fluid intelligence. For DF we found patients performed significantly worse than healthy controls (HC) only on the switch condition. However, no significant difference between left and right frontal patients was found. In contrast, left frontal patients were significantly impaired when compared with HC and right frontal patients on FAS. These lateralization findings were complemented, for the first time, by three neuroimaging; investigations. A traditional frontal subgrouping method found significant differences on FAS between patients with or without Left Inferior Frontal Gyrus lesions involving BA 44 and/or 45. Parcel Based Lesion Symptom Mapping (PLSM) found lower scores on FAS were significantly associated with damage to posterior Left Middle Frontal Gyrus. An increase in rule break errors, so far only anecdotally reported, was associated with damage to the left dorsal anterior cingulate and left body of the corpus callosum, supporting the idea that conflict resolution and monitoring impairments may play a role. Tractwise statistical analysis (TSA) revealed that patients with disconnection; in the left anterior thalamic projections, frontal aslant tract, frontal; orbitopolar tract, pons, superior longitudinal fasciculus I and II performed significantly worse than patients without disconnection in these tracts on FAS. In contrast, PLSM and TSA analyses did not reveal any significant relationship between lesion location and performance on the DF switch condition. Overall, these findings suggest DF may have limited utility as a tool in detecting lateralized frontal executive dysfunction, whereas FAS and rule break behavior appears to be linked to a set of well localized left frontal grey matter regions and white matter tracts.
year | journal | country | edition | language |
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2020-01-01 | Neuropsychologia |