0000000000228480

AUTHOR

Nicola Smith

showing 4 related works from this author

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

2017

lcsh:Diseases of the musculoskeletal systemlcsh:RJ1-570lcsh:Pediatricslcsh:RC925-935Meeting Abstracts
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The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update.

2009

SummarySevere persistent asthma causes a substantial morbidity and mortality burden and is frequently inadequately controlled despite intensive guideline-based therapy. Targeting allergic inflammatory processes that underlie the pathogenesis of severe persistent asthma improves asthma control in a significant proportion of patients. Omalizumab, a humanized monoclonal anti-immunoglobulin E (IgE) antibody, has been developed to target IgE, which is central to triggering and maintaining allergic airway inflammation. In a comprehensive program of clinical trials, omalizumab has been shown to reduce asthma exacerbation and emergency visit rates, and to improve quality of life in patients with se…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyAllergyAllergic asthmaOmalizumabOmalizumabImmunoglobulin EAntibodies Monoclonal HumanizedSeverity of Illness IndexDrug Administration ScheduleInternal medicineSeverity of illnessmedicineHumansDosingAnti-Asthmatic AgentsAsthmaClinical Trials as TopicbiologyDose-Response Relationship Drugbusiness.industryAntibodies MonoclonalGuidelineImmunoglobulin Emedicine.diseaseAsthmaAntibodies Anti-IdiotypicClinical trialImmunologybiology.proteinRespiratoryImmunoglobulin E (IgE)businessmedicine.drugRespiratory medicine
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Fluency and rule breaking behaviour in the frontal cortex

2020

Design (DF) and phonemic fluency tests (FAS; D-KEFS, 2001) are commonly used to investigate voluntary generation. Despite this, several important issues remain poorly investigated. In a sizeable sample of patients with focal left or right frontal lesion we established that voluntary generation performance cannot be accounted for by fluid intelligence. For DF we found patients performed significantly worse than healthy controls (HC) only on the switch condition. However, no significant difference between left and right frontal patients was found. In contrast, left frontal patients were significantly impaired when compared with HC and right frontal patients on FAS. These lateralization findin…

MaleLIFG Left Inferior Frontal GyrusRAPM Raven's Advanced Progressive MatricesIntelligenceLMFG Left Middle Frontal GyrusLF Left frontalAudiologyCorpus callosumCVA cerebrovascular accidentATR Anterior thalamic radiationExecutive FunctionBehavioral NeurosciencePFC prefrontal cortex0302 clinical medicineVerbal fluency testHC healthy controls10. No inequalityPrefrontal cortexLanguageFASRB Phonemic Fluency Rule Breakfluid intelligenceAged 80 and overfunctionsBrain Diseasesprefrontal cortexBrain Neoplasms05 social sciencesSuperior longitudinal fasciculusGNT Graded Naming TestMiddle AgedStrokemedicine.anatomical_structurePLSM Parcel-based Lesion Symptom MappingDF Design FluencyFluid Intelligence Parcel Based Lesion Symptom Mapping tract-wise statistical analysisFemalemedicine.symptomPsychologyAdultmedicine.medical_specialtyAdolescentCognitive NeuroscienceBrain AbscessExperimental and Cognitive PsychologyGrey matterrule break errorsArticle050105 experimental psychologyLateralization of brain functionLesionWhite matterYoung Adult03 medical and health sciencesexecutivestatistical analysismedicineHumans0501 psychology and cognitive sciencesAgedParcel based lesion symptom mapping tract-wise statistical analysisSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicaphonemic and design fluencyRL Right lesionparcel based lesion symptom mapping tractwiseLL left lesionIQ Intelligence QuotientVLSM Voxel-based lesion symptom mappingrule break errorNART National Adult Reading TestPsychomotor PerformanceTSA Tract-wise Statistical Analysis030217 neurology & neurosurgeryNeuropsychologia
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Corrigendum to “The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update” [Respiratory Medicine 103 (2009) 1098…

2010

a Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, D level Centre Block (MP810), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK Mainz University Hospital, 55131 Mainz, Germany Hopital Arnaud de Villeneuve, FR-34000 Montpellier, France Novartis Horsham Research Centre, Horsham, RH12 5AB, UK Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936-1080, USA

Respiratory MedicinePulmonary and Respiratory Medicinemedicine.medical_specialtybusiness.industryResearch centreFamily medicineMedicineAllergic asthmaOmalizumabGeneral hospitalbusinessUniversity hospitalmedicine.drugRespiratory Medicine
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