Search results for "Fatigue."
showing 10 items of 621 documents
Production of innovative, recycled and high-performance asphalt for road pavements
2010
Abstract The paper deals with a specific laboratory study aiming at perfectioning recycled asphalt with high mechanical performance, for surface and structural layers of flexible pavements. The aim of the research was to combine in the same material the maximum possible quantity of recycled asphalt (RA), coming from degraded asphalt layers, together with high structural performance of the recycled mixtures obtained (mainly stability, load spreading properties, rutting and fatigue resistance) that should not be lower, or possibly better than those offered by traditional asphalt mixture, made with virgin binder and aggregate. For this purpose, innovative recycled mixtures, close-graded and wi…
QUANTIFICATION OF MUSCLE FATIGUE WITHWAVELET ANALYSIS BASED ON EMG DURING MYOELECTRICAL STIMULATION
2012
6; International audience; We propose a device dedicated to real time analysis of electromyograms (EMG) under myoelectrical stimulation (ES). The muscular fatigue analysis, which is obtained by the use of a dedicated analog circuit and a processing part, is the main purpose of this study. The description of a hardware device which incorporates an electro-stimulator and an electromyogram amplifier combined to a computer is detailed. Then, we present a muscular fatigue analysis part based on wavelet decomposition in order to extract a fatigue index, which is confronted with synthetic and experimental data. We conclude that the CWT index applies well to M waves. The noise sensitivity is invest…
Optimisation d'un électromyostimulateur intelligent pour le reconditionnement musculaire
2017
This project aims to optimize smart electromyostimulators for the muscular reeducation. The electrostimulator optimization aims to improve the electrostimulation sessions (EMS) by obtaining informations on the muscular electical stimulations and the control application in real time in order to control the muscular response. Various control methods of the muscular force are been developed and applied on an accurate model. In first, the techniques will be applied on the partial model without taking into account the muscular fatigue then in second in taking into account the presence of fatigue and its effects. Theses control methods act on the stimulation parameters in frequency and in amplitu…
Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
2019
Abstract Background Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has historically been associated with grade III pyrexia or photosensitivity depending on the combination used. The objective of this study was to fully describe adverse events from the COLUMBUS study evaluating the most recent BRAF/MEK inhibitor combination encorafenib+binimetinib. Patients and methods Patients with locally advanced, unresectable or metastatic BRAFV600-mutant melanoma were randomised to receive encorafenib 450 mg once daily plus binimetinib 45 mg twice daily, encorafenib 300 mg on…
Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
2001
Neurotrophin-4 (NT-4) is produced by slow muscle fibers in an activity-dependent manner and promotes growth and remodeling of adult motorneuron innervation. However, both muscle fibers and motor neurons express NT-4 receptors, suggesting bidirectional NT-4 signaling at the neuromuscular junction. Mice lacking NT-4 displayed enlarged and fragmented neuromuscular junctions with disassembled postsynaptic acetylcholine receptor (AChR) clusters, reduced AChR binding, and acetylcholinesterase activity. Electromyographic responses, posttetanic potentiation, and action potential amplitude were also significantly reduced in muscle fibers from NT-4 knock-out mice. Slow-twitch soleus muscles from thes…
A thermodynamically consistent CZM for low-cycle fatigue analysis
2018
A cohesive zone model for low-cycle fatigue analysis is developed in a consistent thermodynamic framework of elastic-plastic-damage mechanics with internal variable. A specific fatigue activation condition allows to model the material degradation related to the elastic-plastic cyclic loading conditions, with tractions levels lower than the damage activation condition. A moving endurance surface, in the classic framework of kinematic hardening, enables a pure elastic behavior without any fatigue degradation for low levels loading conditions.
A mixed FES/EMG system for real time analysis of muscular fatigue
2010
International audience; In this article, we present a functional electrical stimulator allowing the extraction in real time of M-wave characteristics from resulting EMG recodings in order to quantify muscle fatigue. This system is composed of three parts. A Labview software managing the stimulation output and electromyogram (EMG) input signal, a hardware part amplifying the output and input signal and a link between the two previous parts which is made up from input/output module (NIdaq USB 6251). In order to characterize the fatigue level, the Continuous Wavelet Transform is applied yielding a local maxima detection. The fatigue is represented on a scale from 0 for a fine shaped muscle to …
A new quasi-static multi-degree of freedom tapered roller bearing model to accurately consider non-Hertzian contact pressures in time-domain simulati…
2014
The accuracy of the fatigue life calculations in rolling bearing simulations is highly dependent on the precision of the roller-raceway contact simulations and the ability to accurately include structural deflections of the supporting structure. Several different methods exist to simulate the pressure distributions, and in time-domain bearing simulations, where many contacts need evaluation, the simple and time efficient methods are more popular. These methods underestimate the fatigue life reduction due to roller end effects, overload and misalignments. Furthermore, existing time-domain rolling bearing models assume that the bearing rings remain circular, which can be a poor approximation…
Multi-objective optimization of nitinol stent design.
2017
Nitinol stents continuously experience loadings due to pulsatile pressure, thus a given stent design should possess an adequate fatigue strength and, at the same time, it should guarantee a sufficient vessel scaffolding. The present study proposes an optimization framework aiming at increasing the fatigue life reducing the maximum strut strain along the structure through a local modification of the strut profile.The adopted computational framework relies on nonlinear structural finite element analysis combined with a Multi Objective Genetic Algorithm, based on Kriging response surfaces. In particular, such an approach is used to investigate the design optimization of planar stent cell.The r…
Fatigue crack growth behaviour of four structural steels in air and in a geothermal fluid environment
1992
Abstract In recent years the exploitation of geothermal energy has expanded rapidly in Italy. This has created a requirement for improved drilling technology, to reduce the number of failures occuring in the drills, which is more frequent than in oil wells. This paper deals with the results obtained in FCCR tests of four materials both in air and in two types of aggressive environments. Deterioration takes place by fatigue, corrosion fatigue and hydrogen embrittlement. It is concluded that the steel G105 is a suitable substitute for S135 in drill pipes, and inspections between drillings may be adequate to prevent failure for small-curvature wells.