Search results for "Ferro"
showing 10 items of 2451 documents
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
Polysubstituted ferrocenes as tunable redox mediators
2018
A series of four ferrocenyl ester compounds, 1-methoxycarbonyl- (1), 1,1’-bis(methoxycarbonyl)- (2), 1,1’,3-tris(methoxycarbonyl)- (3) and 1,1’,3,3’-tetrakis(methoxycarbonyl)ferrocene (4), has been studied with respect to their potential use as redox mediators. The impact of the number and position of ester groups present in 1–4 on the electrochemical potential E1/2 is correlated with the sum of Hammett constants. The 1/1+–4/4+ redox couples are chemically stable under the conditions of electrolysis as demonstrated by IR and UV–vis spectroelectrochemical methods. The energies of the C=O stretching vibrations of the ester moieties and the energies of the UV–vis absorptions of 1–4 and 1+–4+ c…
A multidisciplinary approach using LCCA and micro-simulation 10 model for the management of the urban pavements
2013
The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary ap…
Apparato per tracciare lo stato della superficie di un pavimento e procedimento di bilanciamento dinamico di un tale apparato
2016
Approccio teorico-sperimentale per l'analisi delle condizioni opertaive di rotatorie urbane non convenizonali.
2008
I metodi tradizionali di analisi delle intersezioni a rotatoria non consentono una valutazione attendibile delle condizioni operative del traffico in presenza di schemi organizzativi dell’intersezione, nei quali la geometria, unitamente alla molteplicità delle situazioni di traffico ed all’inserimento in contesti vincolati, induce comportamenti di guida anche molto distanti da quelli osservabili in rotatorie convenzionali. Quanto evidenziato interessa, in particolare, gli schemi circolari di intersezione in area urbana, dove risultano particolarmente diffusi e si caratterizzano per requisiti geometrico-funzionali spesso distanti da quelli propri delle rotatorie convenzionali. I vincoli loca…
Conversion of existing roundabouts into turbo-roundabouts: case studies from real world, Journal of Civil Engineering and Architecture 6(8)
2012
Compared with roundabouts the main advantages of turbo-roundabouts are the reduction in the number of potential conflicting points and the lower speed of vehicles through the intersection; they both can improve road safety conditions at the junction. Moreover, the physical delimitation among lanes limits the side-by-side accident risk. These aspects make turbo-roundabouts more appropriate than roundabouts when a higher level of safety has to be guaranteed, particularly in presence of relevant pedestrian and two-wheels traffic volumes. The present paper has three main objectives : 1) to discuss general design criteria and functional principles of turbo roundabouts; 2) to give the geometric d…
TURBO-ROUNDABOUT GENERAL DESIGN CRITERIA AND FUNCTIONAL PRINCIPLES: CASE STUDIES FROM REAL WORLD
2010
Compared with usual roundabouts the main advantages of turbo-roundabouts are the reduction in the number of potential conflicting points and the lower speed of passing vehicles through the intersection; they both can improve road safety conditions at the junction. Also, the physical delimitation among lanes limits the side-by-side accident risk. These aspects make turbo-roundabouts more appropriate than roundabouts when a higher level of safety has to be guaranteed, particularly in presence of relevant pedestrian and two-wheels traffic volumes. In a previous paper authors proposed a theoretical approach to evaluate turbo-roundabouts capacity founded on gap acceptance theory. In particular, …
Safety diagnostic method in urban circular intersections
2004
The available knowledge of traffic safety at roundabouts is not a complete reference for geometric design; where there are organizational schemes for junctions characterized by a geometric design, quite different driving behaviours are required from those that are observable at roundabouts. This is very frequent in urban areas, where the existing constraints, particularly physical ones, often render it necessary to make “compromise choices” relating to one or more geometric features of the roundabout (central island shape, circulatory roadway width, symmetry and number of the arms, entry width, etc). The objective of this study is to explain the accident phenomenology of this kind of road s…
An Italian experience on crash modeling for roundabouts
2015
In the last few years a considerable amount of safety models and evaluation tasks have been developed and specifically dedicated to roundabouts. Several safety performance functions (SPFs), indeed, have been implemented for roundabouts worldwide. Since SPFs are developed using crashes, traffic volume and other characteristics of a specific site (or geographical area), their direct transferability to other contexts different from those in which SPFs were calibrated is not always possible and, in any case, it must be done very carefully. A safety performance function cannot be used without a transferability evaluation for sites not included in the geographic area for which it was developed. S…