Search results for "Fibrosi"
showing 6 items of 936 documents
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells
2016
Two-Tier Care Pathways for Liver Fibrosis Associated to Non-Alcoholic Fatty Liver Disease in HIV Mono-Infected Patients.
2022
(1) Background: Developing strategies to identify significant liver fibrosis in people with HIV (PWH) is crucial to prevent complications of non-alcoholic fatty liver disease (NAFLD). We aim to investigate if five simple serum biomarkers applied to PWH can optimize a care pathway to identify significant liver fibrosis defined by transient elastography (TE). (2) Methods: A two-tier fibrosis pathway was applied to three prospective cohorts of PWH undergoing TE with CAP. NAFLD was diagnosed as a controlled attenuation parameter ≥ 248 dB/m. Five simple fibrosis biomarkers (FIB-4 < 1.3, BARD score 0–1, NAFLD fibrosis score < −1.455, AST:ALT ratio < 0.8 and APRI < 0.5) …
A NOVEL APPROACH TO FULLY CHARACTERIZE FIBER NETWORK MORPHOLOGY OF PLANAR FIBROUS TISSUES AND SCAFFOLDS
2011
Comprendere come la struttura di uno scaffold influenzi la morfologia cellulare e predirne il comportamento meccanico sono divenuti obiettivi fondamentali nello sviluppo dei tessuti ingegnerizzati. In questo studio si presenta un algoritmo innovativo basato su analisi d’immagine. Vengono introdotti descrittori di micro architettura che identificano univocamente la topologia della rete di fibre: orientamento delle fibre, connettività, densità spaziale delle intersezioni e diametro. Le prestazioni dell’algoritmo sono state valutate utilizzando immagini di microscopio a scansione elettronica (SEM) di (1) scaffolds in poliestere uretano-urea prodotti per elettrospinning, (2) gel di collagene se…