Search results for "Fibrosis"

Exactitud diagnóstica de la resonancia magnética preoperatoria en la determinación de la extensión y grado de actividad inflamatoria de la enfermedad…

2014

Introducción: La correcta identificación de la localización y cuantificación de la actividad inflamatoria de las lesiones de la enfermedad de Crohn es necesaria para establecer cuál es el manejo más adecuado para cada paciente Métodos: Se trata de un estudio prospectivo observacional consecutivo que abarca un periodo de estudio de 30 meses. El diagnóstico se realiza según los criterios de Lennard-Jones y la clasificación de Montreal. Se realizó una resonancia magnética mediante enterografía, con el mismo protocolo y secuencias, en los tres meses previos a la cirugía. Se determinaron las características radiológicas de las lesiones, se obtuvo el índice de actividad de la resonancia magnética…

Resistin, adinonectin, leptin levels in adolescent with cystic fibrosis.

2008

Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codon…

2015

Drug delivery systems based on polymeric micro and nanoparticles for the treatment of cystic fibrosis

Drug-induced infiltrative lung disease

2009

International audience; Because the lung manifestations of drugs may be highly variable, a high index of suspicion is required. Both current and past drug intake should be carefully evaluated in any patient with infiltrative lung disease. Drug-induced infiltrative lung disease may manifest as variable clinical radiological patterns, including subacute or chronic interstitial pneumonia, pulmonary fibrosis, eosinophilic pneumonia (presenting as Loffler syndrome, or chronic or acute eosinophilic pneumonia), organising pneumonia, diffuse alveolar haemorrhage, acute respiratory distress syndrome, pulmonary oedema, lipoid pneumonia, alveolar proteinosis or sarcoidosis. A variety of drugs have bee…

SEAL program – Early detection of liver fibrosis and cirrhosis by screening of the general population

2021

Cuantificación de la fibrosis hepática mediante biomarcadores de imagen

2018

There is a need for early identification of patients with chronic liver diseases due to their increasing prevalence and morbidity-mortality. The degree of liver fibrosis determines the prognosis and therapeutic options in this population. Liver biopsy represents the reference standard for fibrosis staging. However, given its limitations and complications, different non-invasive methods have been developed recently for the in vivo quantification of fibrosis. Due to their precision and reliability, biomarkers' measurements derived from Ultrasound and Magnetic Resonance stand out. This article reviews the different acquisition techniques and image processing methods currently used in the evalu…

Reduced regional systolic function evolved compacted segments in noncompaction

2010

Abstract In a recent report about noncompaction Nemes et al. reported that systolic left ventricular (LV) dysfunction assessed using the wall motion score during 2D echocardiography in noncompaction is not confined to noncompacted LV segments. These results confirmed some published reports of our group. Recently we analyzed a population of 238 patients affected by noncompaction, and demonstrated that the number of noncompacted segment is uncorrelated with the degree of systolic dysfunction. It is an attractive hypothesis that the systolic dysfunction could be depend on the fibrosis of the left ventricle, itself a consequence of microcirculatory dysfunction, which has been confirmed by repor…

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation

2013

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial-to-mesenchymal transition (EMT)] occurs under the influence of transforming growth factor (TGF)-β1, with Snail being a major transcription factor. We study here the role of the heat-shock protein HSP27 in fibrogenesis and EMT. In vitro, we have up- and down-modulated HSP27 expression in mesothelial and epithelial cell lines and studied the expression of different EMT markers induced by TGF-β1. In vivo, we inhibited HSP27 with the antisense oligonucleotide OGX-427 (in phase II clinical trials as anticancer agent)…

Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index.

2011

Background Liver stiffness measurement (LSM) using transient elastography (TE) is used to stage fibrosis in patients with liver disease, diagnostic reliability and the factors affecting its performance in patients with non-alcoholic fatty liver disease (NAFLD) are incompletely understood. Aim To assess LSM. Methods Consecutive NAFLD patients (n = 169), assessed by liver biopsy (Kleiner score), anthropometrical, biochemical and metabolic features, underwent LSM using TE with standard M probe. Results Liver stiffness measurement was not reliable in 23 patients (14%) due to obesity. Among patients with a reliable TE, a LSM value >7.25 kPa was the best cut-off for predicting significant fibrosi…