Search results for "Flip"
showing 10 items of 133 documents
Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression.
2018
Abstract Background: A strong, reciprocal crosstalk between inflammation and melanoma has rigorously been demonstrated in recent years, showing how crucial is a pro-inflammatory microenvironment to drive therapy resistance and metastasis. Purpose: We investigated on the effects of Indicaxanthin, a novel, anti-inflammatory and bioavailable phytochemical from Opuntia Ficus Indica fruits, against human melanoma both in vitro and in vivo. Study Design and Methods: The effects of indicaxanthin were evaluated against the proliferation of A375 human melanoma cell line and in a mice model of cutaneous melanoma. Cell proliferation was assessed by MTT assay, apoptosis by Annexin V-Fluorescein Isothio…
Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status
2016
International audience; All cells are delimited by biological membranes, which are consequently a primary target of stress-induced damage. Cold alters membrane functionality by decreasing lipid fluidity and the activity of membrane proteins. In Saccharomyces cerevisiae, evidence links sphingolipid homeostasis and membrane phospholipid asymmetry to the activity of the Ypk1/2 proteins, the yeast orthologous of the mammalian SGK1-3 kinases. Their regulation is mediated by different protein kinases, including the PDK1 orthologous Pkh1/2p, and requires the function of protein effectors, among them Nce102p, a component of the sphingolipid sensor machinery. Nevertheless, the mechanisms and the act…
Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells
2018
Viruses are present in the intestinal microflora and are currently discussed as a potential causative mechanism for the development of inflammatory bowel disease. A number of viruses, such as Human Herpesvirus-8, express homologs to cellular FLIPs, which are major contributors for the regulation of epithelial cell death. In this study we analyzed the consequences of constitutive expression of HHV8-viral FLIP in intestinal epithelial cells (IECs) in mice. Surprisingly, expression of vFlip disrupts tissue homeostasis and induces severe intestinal inflammation. Moreover vFlip(IEC-tg) mice showed reduced Paneth cell numbers, associated with excessive necrotic cell death. On a molecular level vF…
Flipped classroom in COVID-19 times: a cross-talking perspective
2020
La COVID-19 ha generado una serie de cambios en las diferentes esferas de nuestras vidas. Estos cambios han sido especialmente visibles en el ámbito educativo, donde ha sido necesario repensar los procesos formativos de forma urgente en términos de no presencialidad. En base a esta situación, el presente trabajo presenta una experiencia de Flipped learning llevada a cabo con los estudiantes del primer curso del Grado en Pedagogía de la Universitat de València. Asimismo, se propone un análisis sobre la concepción previa de los estudiantes sobre esta metodología y su percepción tras finalizar su implementación, ofreciendo una visión trasversal. Para ello, se ha recogido la información de los …
Transforming a class from the Psychology degree into a <em>flipped classroom</em>
2016
La flipped classroom es una metodologia docente que trata de modificar la dinamica de la clase tradicional, en la que el alumnado estudia la materia antes de asistir a clase (fundamentalmente mediante Tecnologias de la Informacion y Comunicacion), y el tiempo en el aula se emplea para clarificar contenidos y realizar actividades significativas, con el apoyo continuado del profesorado. Estudios recientes muestran que se han obtenido resultados positivos respecto a la utilizacion de esta metodologia. Sin embargo, la implantacion de esta metodologia en el grado en Psicologia es escasa. Por ello, el objetivo de este trabajo fue aplicar la metodologia flipped classroom en un tema de la asignatur…
Video Viewing Patterns Using Different Teaching Treatments: A Case Study Using YouTube Analytics
2019
Aquest estudi explora els patrons de visualització de 17 vídeos en un context tradicional daprenentatge i en un context de classe invertida per 723 estudiants de negocis cursant un mòdul relacionat amb . Mentre recerques anteriors s?han centrat principalment en resultats (per exemple, satisfacció/resultats dels alumnes), en aquest estudi l?enfocament recau en com la natura de les interaccions del estudiants amb el vídeos por determinar-se mitjançant un anàlisi profund de les dades analítiques. Els nostres resultats mostren menys interacció amb els vídeos en el context de la classe invertida que en el de la classe tradicional. De la mateixa manera, mostren un ús més elevat dels vídeos com a …
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
2022
Funder: European Commission
Imaging of the lungs using 3he MRI: Preliminary clinical experience in 18 patients with and without lung disease
1997
The purpose of this study was to describe the 3He MRI findings of normal pulmonary ventilation in healthy volunteers and to evaluate abnormalities in patients with different lung diseases. Hyperpolarized 3He gas (300 ml, 3 x 10(5) Pa, polarized to 35-45% by optical pumping, provided in special glass cells) was inhaled by 8 healthy volunteers and 10 patients with different lung diseases. Imaging was performed with a three-dimensional fast low-angle shot (FLASH) sequence (TR = 11.8 msec; TE = 5 msec; transmitter amplitude, 5-8 V; corresponding flip angle, < 5 degrees) in a single breath-hold (22-42 seconds). Clinical and radiological examinations were available for correlation. The studies we…
Quantification of Regional Intrapulmonary Oxygen Partial Pressure Evolution during Apnea by 3He MRI
1999
We present a new method to determine in vivo the temporal evolution of intrapulmonary oxygen concentrations by functional lung imaging with hyperpolarized (3)Helium ((3)He-->). Single-breath, single-bolus visualization of (3)He--> administered to the airspaces is used to analyze nuclear spin relaxation caused by the local oxygen partial pressure p(O(2))(t). We model the dynamics of hyperpolarization in the lung by rate equations. Based hereupon, a double acquisition technique is presented to separate depolarization by RF pulses and oxygen induced relaxation. It permits the determination of p(O(2)) with a high accuracy of up to 3% with simultaneous flip angle calibration using no additional …
Videotutoriales para la enseñanza de los Sistemas de Información Geográfica aplicados a la arqueología
2019
La experiencia que presentamos aquí se llevó a cabo durante el curso 2018-2019 en las clases prácticas de la asignatura Metodología Arqueológica (tercer curso del grado de Historia). El objetivo de aprendizaje principal de las clases prácticas de esta asignatura se focaliza en que el alumnado se familiarice con las herramientas básicas de los Sistemas de Información Geográfica (SIG) que le permitan resolver problemas de naturaleza arqueológica. Para ello, durante el curso, decidimos aplicar nuevos recursos (vídeo tutoriales) y nuevas metodologías (Flipped Teaching), con el interés de mejorar los resultados de aprendizaje del alumnado. La metodología implica la inversión de la taxonomía de B…