Search results for "Fluorine"

Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

2021

Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.

Survey on fluoride, bromide and chloride contents in public5 drinking water supplies in Sicily (Italy)

2008

Synthesis of novel fluorinated building blocks and α-helix peptidomimetics

2018

At its heart, the present PhD thesis is based on the premise of two important areas in modern organic chemistry: firstly, the development of new methodologies to incorporate fluorine into organic molecules; and secondly, the design and synthesis of small molecules with high therapeutic potential. The work presented in the first three chapters will therefore focus on the incorporation of fluorine into organic molecules and the synthesis of fluorinated building blocks. In each chapter, we aim to obtain biologically relevant small molecules containing fluorine atoms or fluorinated groupings. The introduction of fluorine is a commonly used method in drug discovery to fine-tune the properties of…

Fluorine speciation in topsoils of three active volcanoes of Sicily (Italy)

2008

Fluorine is one of the many environmental harmful elements released by volcanic activity. The content of total oxalate-extractable and water-extractable fluorine was determined in 96 topsoils of three active volcanic systems of southern Italy (Mt Etna, Stromboli and Vulcano). Total fluorine (F) content (F TOT) ranges from 112 to 7,430 mg kg−1, F extracted with oxalate (F OX) ranges from 16 to 2,320 mg kg−1 (2–93% of F TOT) and F extracted with distilled water ( $$ F_{{{\text{H}}_{{\text{2}}} {\text{O}}}} $$ ) ranges from 1.7 to 159 mg kg−1 (0.2–40 % of F TOT). Fluorine in the sampled topsoils derives both from the weathering of volcanic rocks and ashes and from the enhanced deposition due t…

Asymmetric Synthesis of Fluorinated Isoindolinones through Palladium-Catalyzed Carbonylative Amination of Enantioenriched Benzylic Carbamates

2015

The asymmetric synthesis of fluorinated isoindolinones has been achieved by a palladium-catalyzed aminocarbonylation reaction of the corresponding -fluoroalkyl o-iodobenzylamines. A base-mediated anti -hydride elimination process was suggested to explain the partial erosion of the optical purity observed in some cases. This mechanistic rationale enabled the minimization of this partial racemization by fine-tuning the pK(a) of the base.

The enrichment ratio of atomic contacts in crystals, an indicator derived from the Hirshfeld surface analysis

2014

An enrichment ratio is derived from the decomposition of the crystal contact surface between pairs of interacting chemical species. The propensity of different contact types to form is investigated.

Halogen bonding and host–guest chemistry between N-alkylammonium resorcinarene halides, diiodoperfluorobutane and neutral guests

2019

Single crystal X-ray structures of halogen-bonded assemblies formed between host N-hexylammonium resorcinarene bromide (1) or N-cyclohexylammonium resorcinarene chloride (2), and 1,4-diiodooctafluorobutane and accompanying small solvent guests (methanol, acetonitrile and water) are presented. The guests’ inclusion affects the geometry of the cavity of the receptors 1 and 2, while the divalent halogen bond donor 1,4-diiodooctafluorobutane determines the overall nature of the halogen bond assembly. The crystal lattice of 1 contains two structurally different dimeric assemblies A and B, formally resulting in the mixture of a capsular dimer and a dimeric pseudo-capsule. 1H and 19F NMR analyses …

Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence.

2017

A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation.

Rapid self-healing and anion selectivity in metallosupramolecular gels assisted by fluorine-fluorine interactions.

2017

Simple ML2 [M = Fe(II), Co(II), Ni(II)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2′,6,2′-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz. self-healing, and thermal rearrangement in aqueous dimethyl sulfoxide. The key factor for gelation and rheological properties emerges from the fluorine–fluorine interactions between the perfluorinated chains, as the corresponding hydrocarbon derivative did not form metallogels. The perfluoro-terpyridine ligand alone formed single crystals, while its Fe(II), Co(II) or Ni(II) complexes underwent rapid gelation leading to highly enta…

Visualization of inert gas wash-out during high-frequency oscillatory ventilation using fluorine-19 MRI

2010

High-frequency oscillatory ventilation is looked upon as a lung-protective ventilation strategy. For a further clarification of the physical processes promoting gas transport, a visualization of gas flow and the distribution of ventilation are of considerable interest. Therefore, fluorine-19 magnetic resonance imaging of the imaging gas octafluorocyclobutane (C(4) F(8) ) during high-frequency oscillatory ventilation was performed in five healthy pigs. For that, a mutually compatible ventilation-imaging system was set up and transverse images were acquired every 5 sec using FLASH sequences on a 1.5 T scanner. Despite a drop in signal-to-noise ratio after the onset of high-frequency oscillato…