Search results for "Forming"
showing 10 items of 1719 documents
Energy and Resource efficient Forming Processes
2010
Environmental modelling of aluminium based components manufacturing routes: Additive manufacturing versus machining versus forming
2018
Abstract Additive Manufacturing represents, by now, a viable alternative for metal-based components production. Therefore the designer, often, has to select among three options at process design stage: subtractive, mass conserving, and additive approaches. The selection of a given process, besides affecting the manufacturing step impact, influences significantly the impact related to the material production step. If the process enables a part weight reduction (as the Additive Manufacturing approaches do) even the use phase is affected by the manufacturing approach selection. The present research provides a comprehensive environmental manufacturing approaches comparison for components made o…
A methodology for the environmental comparison of metal shaping technologies: an in-depth analysis on recycling related issues
2015
The reduction of CO2 emissions is an urgent objective to pursue. The scientific and the industrial world have gathered such challenge, starting to find out energy- and resource-efficient manufacturing strategies. From the literature review, in the domain of environmental impact analysis of manufacturing processes, two relevant knowledge gaps can be spotted: (1) the metal forming processes (and, in particular, the bulk forming processes) are still not well documented, and (2) there is a lack of systematic and comparative studies on energy and material flows enabling the identification of environmentally-friendly manufacturing design strategies. This research offers a contribution to a better…
La prostituta de Babilonia. La reinvención del tipo iconográfico: de la Biblia al audiovisual
2019
ABSTRACTA good part of the visual contemporaneity is the result of a reconfiguration of formal elements of the past. In this context is the Whore of Babylon, a biblical iconographic type that has been reinterpreted through Daenerys Targaryen in the audiovisual, specifically in the TV series Game of Thrones.RESUMENBuena parte de la contemporaneidad visual es el resultado de una reconfiguracion de elementos formales del pasado. En este contexto se encuentra la prostituta de Babilonia, un tipo iconografico biblico que ha sido reinterpretado a traves de Daenerys Targaryen en el audiovisual, concretamente en la serie televisiva Game of Thrones.
Mycoplasma fermentans-derived lipid inhibits class II major histocompatibility complex expression without mediation by interleukin-6, interleukin-10,…
1996
Mycoplasma cause several diseases in man and animals. Some strains can chronically infect humans, leading to fever or inflammatory syndromes such as arthritis, particularly in immunosuppressed patients. A set of pathogenicity factors shared by many mollicutes may be membrane components that activate macrophages to secrete cytokines and other inflammatory mediators. Mycoplasma-derived high molecular weight material (MDHM) is a macrophage-activating amphiphilic lipid which was purified from Mycoplasma fermentans. We studied the influence of MDHM on the expression of major histocompatibility complex (MHC) class II molecules by mouse resident peritoneal macrophages with an ELISA. Highly purifie…
Immune ambivalence: The schizophrenic bleomycin.
2013
In addition to cytotoxic effects, anticancer agents can exert multiple immunomodulatory functions. We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+ T cell responses; and 2) induce the secretion of transforming growth factor β (TGFβ), which stimulates regulatory T cells. This suggests that bleomycin may be favorably combined with TGFβ-targeting strategies.
Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells
2004
The objective of our study was to determine the regulatory effects that endogenous transforming growth factor beta (TGFbeta) exerts on T cells in the pathogenesis of collagen-induced arthritis (CIA). CIA was induced in transgenic mice expressing a dominant negative TGFbeta type II receptor in T cells under the control of the human CD2 promoter. Clinical and histological arthritis scores were determined and experiments on disease induction and the healing phase of disease were performed. The proliferation and cytokine production of draining lymph node cells in vitro were analyzed. Transgenic mice were more susceptible to induction of CIA. The overall incidence was higher in transgenic mice t…
Intracellular accumulation of incompletely processed transforming growth factor-alpha polypeptides in ground glass hepatocytes of chronic hepatitis B…
1996
Abstract Background: Transforming growth factor-alpha is an intracellularly processed and secreted polypeptide that induces a proliferative response in epithelial target cells and represents a potential regulatory factor in embryonic development, liver regeneration, and also hepatocarcinogenesis. We have observed focal transforming growth factor-alpha expression in liver tissues with chronic hepatitis B virus infection. Methods: To further elucidate the nature of this focal transforming growth factor-alpha accumulation were have analyzed overall 23 different liver tissues with chronic hepatitis B virus and hepatitis C virus infection as well as normal liver tissues by immunohistology, ELISA…
The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-A…
2019
Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which was meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05–2.37, p = 0.029, I2 = 84%), also after having adjusted for potential…
Infectious Tolerance
2002
Regulatory CD4(+)CD25(+) T cells (Treg) are mandatory for maintaining immunologic self-tolerance. We demonstrate that the cell-cell contact-mediated suppression of conventional CD4(+) T cells by human CD25(+) Treg cells is fixation resistant, independent from membrane-bound TGF-beta but requires activation and protein synthesis of CD25(+) Treg cells. Coactivation of CD25(+) Treg cells with Treg cell-depleted CD4(+) T cells results in anergized CD4(+) T cells that in turn inhibit the activation of conventional, freshly isolated CD4(+) T helper (Th) cells. This infectious suppressive activity, transferred from CD25(+) Treg cells via cell contact, is cell contact-independent and partially medi…