Search results for "Fourier transform ion cyclotron resonance"
showing 10 items of 70 documents
Internal ion impact ionization for Fourier-transform ion cyclotron resonance
1994
A general scheme for ionization and fragmentation of ions in Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICRMS) is introduced. The technique is based upon excitation of high-frequency (i.e. lowmass) primary ions (e.g. N, Al+, H2O+·) which may be generated by standard ionization methods (e.g. electron ionization or laser desorption) inside the trap. Generation of the primary ions is followed by excitation of their cyclotron motion to high translational energy to serve as projectile ions. The projectiles serve two functions: to ionize neutral gas atoms and/or molecules (secondary ions) within the trap internal ion impact ionization (IIII), and to collisionally activate the…
Making Broad Proteome Protein Measurements in 1−5 min Using High-Speed RPLC Separations and High-Accuracy Mass Measurements
2005
The throughput of proteomics measurements that provide broad protein coverage is limited by the quality and speed of both the separations as well as the subsequent mass spectrometric analysis; at present, analysis times can range anywhere from hours (high throughput) to days or longer (low throughput). We have explored the basis for proteomics analyses conducted on the order of minutes using high-speed capillary RPLC combined through on-line electrospray ionization interface with high-accuracy mass spectrometry (MS) measurements. Short 0.8-microm porous C18 particle-packed 50-microm-i.d. capillaries were used to speed the RPLC separations while still providing high-quality separations. Both…
The Ramsey method in high-precision mass spectrometry with Penning traps: Experimental results
2007
The highest precision in direct mass measurements is obtained with Penning trap mass spectrometry. Most experiments use the interconversion of the magnetron and cyclotron motional modes of the stored ion due to excitation by external radiofrequency-quadrupole fields. In this work a new excitation scheme, Ramsey's method of time-separated oscillatory fields, has been successfully tested. It has been shown to reduce significantly the uncertainty in the determination of the cyclotron frequency and thus of the ion mass of interest. The theoretical description of the ion motion excited with Ramsey's method in a Penning trap and subsequently the calculation of the resonance line shapes for differ…
Theory of simultaneous dipole and quadrupole excitation of the ion motion in a Penning trap
2012
Abstract Penning traps confine ions of atoms and molecules as well as other charged particles by a combination of static electric and magnetic fields to the central region of the trap, where these objects can be studied. Most experiments employ pulses of dipolar radio-frequency radiation followed by pulses of quadrupolar radio-frequency radiation to manipulate the motional state of the trapped particles. Instead of a sequential procedure an excitation of the ion motion by the simultaneous application of dipolar and quadrupolar rf-fields is also conceivable. This paper investigates the theory of simultaneous excitation under very general assumptions, with inclusion of possible damping terms.…
Quadrupole excitation of stored ion motion at the true cyclotron frequency
1995
Abstract The motion of an ion in a Penning trap has been investigated in the presence of an azimuthal quadrupole radio frequency field and a damping force provided by buffer gas collisions. Analytical expressions are derived which describe the line shape of the cyclotron resonance as well as the properties of the mass-selective cooling mechanism for heavy ions. Excellent agreement is observed between theoretical results and experimental data obtained with the tandem Penning trap mass spectromer ISOLTRAP at ISOLDE (CERN).
Excitation modes for fourier transform-ion cyclotron resonance mass spectrometry.
1992
AbstractVarious geometric configurations for the excitation of coherent ion motion in Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR/MS) are analyzed (in some cases for the first time) with unified notation. The instantaneous power absorption, F·v, in which v is ion velocity and F the force produced by the applied excitation electric field (harmonic, single frequency, on-resonance, in-phase), is time averaged and then set equal to the time rate of change of ion total (cyclotron + magnetron + trapping) energy, to yield a differential equation that is readily solved for the (time-dependent) amplitude of each of the various ion motions. The standard FT-ICR excitation (name…
Theory of quadrupole detection fourier transform-ion cyclotron resonance
1991
Abstract The theoretical basis of the recently introduced quadrupole detection Fourier transform-ion cyclotron resonance technique is developed by use of the concept of image charges induced in the detection electrodes. The appearance of resonances at frequencies 2ω+, 2ω−, (ω+ + ω−) and (ω+ − ω−) is explained. The new method is compared with the standard (dipole) detection scheme. Techniques are suggested allowing the simultaneous determination of all resonance frequencies ω+ (perturbed, or reduced, cyclotron frequency), ω− (magnetron frequency) and ωz (trapping frequency).
The elliptical Penning trap: Experimental investigations and simulations
2008
Abstract The application of an additional azimuthal quadrupolar electrostatic field to a Penning trap leads to a field configuration referred to as an elliptical Penning trap. The resulting changes of the radial ion motions have been investigated experimentally and by use of simulations. The eigenfrequencies, i.e., the magnetron frequency ω ˜ − and the reduced cyclotron frequency ω ˜ + , are found to be shifted with respect to those of the standard Penning trap ω − , ω + , respectively. As the shift of the magnetron frequency ω ˜ − is larger than that of the reduced cyclotron frequency ω ˜ + their sum ω ˜ + + ω ˜ − is also a function of the ellipticity and no longer equal to the cyclotron f…
Mass measurements of very high accuracy by time-of-flight ion cyclotron resonance of ions injected into a penning trap
1989
Abstract The possibility of absolute mass measurements using time-of-flight detection of ion cyclotron resonance on ions injected into a Penning trap has been demonstrated. Resolving powers of 2 million have been achieved, with accuracies of about 0.5 ppm. Absolute accuracy is obtained by direct observation of the sum frequency of the cyclotron and the magnetron motions through the use of an azimuthal quadrupole r.f. field to transform initial magnetron motion into cyclotron motion. Imperfections of the Penning trap leading to systematic errors are discussed. The system has been designed specifically to measure the masses of radionuclides produced at the on-line isotope separator ISOLDE. Wi…
Damping effects in Penning trap mass spectrometry
2011
Abstract Collisions of ions with residual gas atoms in a Penning trap can have a strong influence on the trajectories of the ions, depending on the atom species and the gas pressure. We report on investigations of damping effects in time-of-flight ion-cyclotron resonance mass spectrometry with the Penning trap mass spectrometers ISOLTRAP at ISOLDE/CERN (Geneva, Switzerland) and SHIPTRAP at GSI (Darmstadt, Germany). The work focuses on the interconversion of the magnetron and cyclotron motional modes, in particular the modification of the resonance profiles for quadrupolar excitation due to the damping effect of the residual gas. Extensive experiments have been performed with standard and Ra…