Search results for "Fracture"
showing 10 items of 873 documents
Histopathological and immunohistochemical aspects of bone tissue in aseptic necrosis of the femoral head
2021
Femoral head osteonecrosis, also known as avascular necrosis, is a disease with a multifactorial etiology, characterized by a profound change of bone architecture, which leads to the diminishing of bone resistance and femoral head collapse. The main causes that lead to femoral head necrosis are represented by the decrease of local blood perfusion and increase of intraosseous pressure, because of an excessive development of adipose tissue in the areolas of the trabecular bone tissue in the femoral head. The histopathological and immunohistochemical (IHC) study performed by us showed that most of bone trabeculae were damaged by necrotic-involutive processes, their sizes being reduced, both re…
Terpenoid treatment in osteoporosis: this is where we have come in research.
2021
Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and functional limitations. Terpenoids, with their activities against bone resorption, have recently received increased attention from researchers. They are potentially more suitable for long-term use compared with traditional therapeutics. In this review of the literature of the past 5 years, we provide comprehensive information on terpenoids, with their anti-osteoporotic effects, highlighting molecular mechanisms that are often in epigenetic key and a possible p…
Preventive effect of risedronate on bone loss and frailty fractures in elderly women treated with anastrozole for early breast cancer.
2011
The aim of this study was to assess the effect of adjuvant anastrozole, alone or associated with risedronate, on BMD and bone fracture risk in women more than 70 years old with hormone receptor-positive early breast cancer (EBC). In a group of 51 elderly women (aged 76.4 ± 5.0 years) considered for adjuvant aromatase inhibitors for EBC, 24 patients with T-scores ≥ -2 and no prevalent fractures received anastrozole 1 mg/day (group A), and 27 patients with T-scores < -2, or with T-scores ≥ -2 and prevalent fractures (group B), received anastrozole (1 mg/day) plus risedronate (35 mg/week). Both groups received supplementation with 1 g calcium carbonate and 800 IU vitamin D per day. Differen…
Virtual prototyping of a new intramedullary nail for tibial fractures
2012
In this work a new distal interlocking system has been developed which is easy to use, allows a reduction of the operating time and consequently the exposure to radiations both for surgeon and patient. The main goal of this study has been the design of a new intramedullary nail for tibial fractures able to simplify and speed up the distal locking operation phases. After a preliminary stage during which several candidate concepts have been proposed and analysed, the best solution has been developed and deeply investigated. The new system, called “expansion nail”, has been firstly modelled by setting up a full parametric CAD model and, then, tested by running non linear FEM analyses to evalua…
An Intelligent Tool to Predict Fracture in Sheet Metal Forming Operations
2007
One of the main issues in sheet metal forming operations design is the determination of formability limits in order to prevent necking and fracture. In fact, the ability to predict fracture represents a powerful tool to improve the production quality in mechanical industry. Many researchers investigated the problem here addressed, mainly studying forming limit diagrams (FLD) or developing fracture criteria which are able to foresee fracture defects for different processes. In this paper, the author present some early results of a research project focused on the application of artificial intelligence (AI) for ductile fracture prediction in sheet metal forming operations. The main advantage o…
Mooring Line Components With Semi-Brittle Behavior: Verification of Fitness for Purpose
2011
Low impact energy for Charpy V Notch (CVN) specimens and associated low Crack Tip Opening Displacement (CTOD) values have occurred on several occasions in high strength steel offshore mooring components. In the present work an Engineering Critical Assessment (ECA) for shackles has been carried out to demonstrate fitness for purpose. Typical values for CVN and CTOD are 17 Joules and 0.01 mm respectively at design temperature. The purpose of the present work is to demonstrate that even in the case where normal quality requirements are not met, the shackles may still have enough structural integrity and fatigue durability to withstand the load spectrum in the field during the planned target se…
Numerical Analysis of Piezoelectric Active Repair in the Presence of Frictional Contact Conditions
2013
The increasing development of smart materials, such as piezoelectric and shape memory alloys, has opened new opportunities for improving repair techniques. Particularly, active repairs, based on the converse piezoelectric effect, can increase the life of a structure by reducing the crack opening. A deep characterization of the electromechanical behavior of delaminated composite structures, actively repaired by piezoelectric patches, can be achieved by considering the adhesive layer between the host structure and the repair and by taking into account the frictional contact between the crack surfaces. In this paper, Boundary Element (BE) analyses performed on delaminated composite structures …
Central Bursting Defects in Drawing and Extrusion: Numerical and Ultrasonic Evaluation
1993
Abstract A new approach for the prediction of central bursting defects in extrusion and drawing is proposed: a finite element analysis of the processes has been carried out, and the obtained results have been elaborated by means of a post-processor, which, employing a proper ductile fracture criterion, is able to suggest if and where the central burst occur. An ultrasonic control system able to detect the insurgence of defects with a resolution of 0.2 mm. has been setup in order to verify the predictive capability of the model. The experimental results show a good agreement with the numerical predictions confirming the effectiveness of the proposed approach, whose industrial application app…
Fatigue crack growth behaviour of four structural steels in air and in a geothermal fluid environment
1992
Abstract In recent years the exploitation of geothermal energy has expanded rapidly in Italy. This has created a requirement for improved drilling technology, to reduce the number of failures occuring in the drills, which is more frequent than in oil wells. This paper deals with the results obtained in FCCR tests of four materials both in air and in two types of aggressive environments. Deterioration takes place by fatigue, corrosion fatigue and hydrogen embrittlement. It is concluded that the steel G105 is a suitable substitute for S135 in drill pipes, and inspections between drillings may be adequate to prevent failure for small-curvature wells.
The Transverse Crack Tension test revisited
2016
Several problems arise when measuring the mode II interlaminar fracture toughness using a Transverse Crack Tension specimen; in particular, the fracture toughness depends on the geometry of the specimen and cannot be considered a material parameter. A preliminary experimental campaign was conducted on TCTs of different sizes but no fracture toughness was measured because the TCTs failed in an unacceptable way, invalidating the tests. A comprehensive numerical and experimental investigation is conducted to identify the main causes of this behaviour and a modification of the geometry of the specimen is proposed. It is believed that the obtained results represent a significant contribution in …