Search results for "Fragment"

The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide

2002

Ras-homologous GTPases are involved in the regulation of genotoxic stress-induced gene expression and cell death. Since they need C-terminal isoprenylation for correct intracellular localization and function, we investigated whether depletion of cells from isopren precursor moieties using the HMG-CoA reductase inhibitor lovastatin affects cellular sensitivity to DNA damaging drugs. Here we show that lovastatin renders cells highly resistant to the tumor-therapeutic compound doxorubicin. Desensitization by lovastatin was reverted by co-treatment with GGPP indicating that inhibition of protein geranylgeranylation is involved in acquired doxorubicin resistance. Lovastatin does not influence ce…

Wind tunnel study on the size distribution of droplets after collision induced breakup of levitating water drops

2018

Abstract Wind tunnel experiments on collisions between drop pairs of 2.5 and 0.5 mm diameter have been performed and the coalescence and breakup events have been recorded by a high-speed digital camera. From the comprehensive analysis of the captured images, the most important parameters utilized in numerical models, such as coalescence efficiency, breakup type, number of fragments and fragment size distribution after breakup were determined. The experimentally obtained parameters have been compared to parameterizations based on earlier laboratory studies of Low and List, and on direct numerical simulations. A very good agreement between experimental results and parameterizations has been f…

Sorting signals in the cytosolic tail of plant p24 proteins involved in the interaction with the COPII coat.

2004

The ability of the cytosolic tail of a plant p24 protein to bind COPI and COPII subunits from plant and animal sources in vitro has been examined. We have found that a dihydrophobic motif in the -7,-8 position (relative to the cytosolic carboxy-terminus), which strongly cooperates with a dilysine motif in the -3,-4 position for COPI binding, is required for COPII binding. In addition, we show that COPI and COPII coat proteins from plant cytosol compete for binding to the sorting motifs in these tails. Only in the absence of the dilysine motif in the -3,-4 position or after COPI depletion could we observe COPII binding to the p24 tail. This competition is not observed when using rat liver cy…

La agrupación temporal y los patrones como facilitadores de la comprensión psicológica de la información rítmica

2020

Grouping influences the mental fragmentation of sounds in memory, which is why it is considered a fundamental element in modern theories of musical cognition. This work reviews research on the phenomena of temporal structuring, grouping of events and formation of rhythmic patterns. Therefore, an updated panorama is offered regarding certain facilitating factors of temporal processing that may be relevant in musical training contexts, for example, that regularity and the 2:1 relationship are important elements for the perception and production of rhythmic patterns. La agrupación influye en la fragmentación de sonidos en la memoria, por lo que es considerada un elemento fundamental en las teo…

The fragmentation of 5- and 3-substituted thiophene-2-carboxamides under electron impact

1980

The 70 eV electron impact mass spectra of twelve 5- and 3-substituted thiophene-2-carboxamides are discussed with the aid of exact mass measurements and labelling experiments. All mass spectra exhibit pronounced molecular ions. Some isomeric 5- and 3-substituted title compounds can be differentiated by mass spectrometry. The fragmentation is influenced by a strong ‘ortho-effect’ which activates the NH3 elimination. In the other cases the most important fragmentation is NH2˙ loss, followed by CO elimination.

Multicollision-induced dissociation of multiply charged gold clusters, Aun2+, n = 7–35, and Aun3+, n = 19–35

2000

Abstract Multicollision-induced dissociation (MCID) has been applied to gold clusters, Au n 2+ (n = 7–35) and Au n 3+ (n = 19–35) stored in a Penning trap. By application of ion cyclotron resonance excitation and pulses of argon collision gas, fragmentation yields have been measured as a function of the clusters’ kinetic energy. The corresponding dissociation energies have been determined by use of the impulsive collision theory and the quantum Rice–Ramsperger–Kassel (RRK) model for the energy transfer to internal cluster modes and for delayed dissociation, respectively. As compared to earlier measurements of singly charged gold clusters the variation of the stability as a function of clust…

Forbidden Factors and Fragment Assembly

2001

In this paper methods and results related to the notion of minimal forbidden words are applied to the fragment assembly problem. The fragment assembly problem can be formulated, in its simplest form, as follows: reconstruct a word w from a given set I of substrings (fragments ) of a word w . We introduce an hypothesis involving the set of fragments I and the maximal length m(w) of the minimal forbidden factors of w . Such hypothesis allows us to reconstruct uniquely the word w from the set I in linear time. We prove also that, if w is a word randomly generated by a memoryless source with identical symbol probabilities, m(w) is logarithmic with respect to the size of w . This result shows th…

Conflict between parasites with different transmission strategies infecting an amphipod host

2005

Competition between parasites within a host can influence the evolution of parasite virulence and host resistance, but few studies examine the effects of unrelated parasites with conflicting transmission strategies infecting the same host. Vertically transmitted (VT) parasites, transmitted from mother to offspring, are in conflict with virulent, horizontally transmitted (HT) parasites, because healthy hosts are necessary to maximize VT parasite fitness. Resolution of the conflict between these parasites should lead to the evolution of one of two strategies: avoidance, or sabotage of HT parasite virulence by the VT parasite. We investigated two co-infecting parasites in the amphipod host, G…

The reconstitution of human C1, the first complement component Binding of C1r and C1s to C1q influences the C1q conformation

1981

Equivalence closure in the two-variable guarded fragment

2015

We consider the satisfiability and finite satisfiability problems for the extension of the two-variable guarded fragment in which an equivalence closure operator can be applied to two distinguished binary predicates. We show that the satisfiability and finite satisfiability problems for this logic are 2-ExpTime-complete. This contrasts with an earlier result that the corresponding problems for the full two-variable logic with equivalence closures of two binary predicates are 2-NExpTime-complete.