6533b82afe1ef96bd128c13e
RESEARCH PRODUCT
The fragmentation of 5- and 3-substituted thiophene-2-carboxamides under electron impact
Salvatore FisichellaGaetano AlberghinaSalvatore OcchipintiOrazio PuglisiLeopoldo Ceraulosubject
Collision-induced dissociationAnalytical chemistryPhotochemistryMass spectrometryBiochemistryIonMasschemistry.chemical_compoundchemistryFragmentation (mass spectrometry)Mass spectrumThiopheneMolecular MedicineInstrumentationSpectroscopyElectron ionizationdescription
The 70 eV electron impact mass spectra of twelve 5- and 3-substituted thiophene-2-carboxamides are discussed with the aid of exact mass measurements and labelling experiments. All mass spectra exhibit pronounced molecular ions. Some isomeric 5- and 3-substituted title compounds can be differentiated by mass spectrometry. The fragmentation is influenced by a strong ‘ortho-effect’ which activates the NH3 elimination. In the other cases the most important fragmentation is NH2˙ loss, followed by CO elimination.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-12-01 | Organic Mass Spectrometry |