Search results for "Frame"
showing 10 items of 1767 documents
Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracel…
2010
Abstract Background A bacterial artificial chromosomal library of Planobispora rosea, a genetically intractable actinomycete strain, was constructed using Escherichia coli-Streptomyces artificial chromosome (ESAC) and screened for the presence of genes known to be involved in the biosynthesis of antibiotics. Results One clone with a 40 kb insert showed antimicrobial activity against Gram positive bacteria. Insert sequence analysis and subcloning experiments revealed that the bioactivity was due to a 3.5 kb DNA fragment containing two open reading frames. These orfs encode two proteins with high similarity to a putative membrane protein of Streptomyces coelicolor and to the nogalamycin resis…
Fostering Collaborative Governance in Chronic Disease Management Programs: A Dynamic Performance Management Approach
2020
Chronic diseases are the leading cause of disability and mortality in the world and represent a global health emergency due to the increase in frequency and complexity that has been occurring in recent years. The outcomes related to chronic care needs depend on the joint effort of a multi-provider, multi-disciplinary, and multi-professional service network, which operates along a clinical pathway. However, all the different players involved in the provision of services may have different interests and goals derived from their organizational structure and their role in the overall health system. This context of fragmented governance makes performance management of care services problematic. …
Towards Next Generation System Architecture for Emergency Services
2011
European Union has decided that all emergencies can be reported to authorities by European citizens by calling 112 or sending a text message to 112. Distributing warnings and alerts of authorities to citizens currently happens through national TV and radio channels, but telecom networks are also used now in some countries for this purpose. During the last ten years there have been attempts to develop new system architectures for various emergency service provision phases. Some of them are already deployed in special cases, like in ambulance services. Multimedia emergency alert messages can be delivered to citizens over fixed and mobile telecom networks and commercial systems are already in …
Global trends in a fragile context : public–nonpublic collaboration, service delivery and social innovation
2020
PurposeThis study aims to enhance the understanding of the nature of collaboration between public and nonpublic actors in delivering social services and achieving social innovation in a fragile context, with an emphasis on the role of civil society organisations (CSOs). The paper focuses on Bosnia and Herzegovina, a Southeastern European country which has faced a turbulent post-conflict transition and experienced challenges in its social welfare policy and practice.Design/methodology/approachThis study uses institutional theory, particularly new institutionalism and institutional networking, as a lens through which to understand public and nonpublic collaboration and social innovation withi…
Frames for fusions of modal logics
2018
Let us consider multimodal logics and . We assume that is characterised by a class of connected frames, and there exists an -frame with a so-called -starting point. Similarly, the logic is characterised by a class of connected frames, and there exists an -frame with a -starting point. Using isomorphic copies of the frames and , we construct a connected frame which characterises the fusion . The frame thus obtained has some useful properties. Among others, is countable if both and are countable, and there is a special world of the frame such that any formula is valid in the frame if and only if it is valid at the point . We also describe a similar construction where we assume the existence o…
Stability of genetic regulatory networks with time-varying delay: Delta operator method
2015
This paper investigates the stability problem for a class of uncertain genetic regulatory networks (GRNs) with time-varying delay via delta operator approach. Both the parameter uncertainty and the generalized activations are considered in the model under study. By constructing an appropriate Lyapunov-Krasovskii functional, the stability and robust stability conditions of GRNs are presented under the delta operator frame. These conditions can be expressed in terms of linear matrix inequalities (LMIs). Finally, a numerical example is employed to illustrate the effectiveness of the proposed results.
Sequencing and analysis of the gene encoding the α-toxin of Clostridium novyi proves its homology to toxins A and B of Clostridium difficile
1995
A library of total Clostridium novyi DNA was established and screened for the alpha-toxin gene (tcn alpha) by hybridization with oligonucleotides derived from a partial N-terminal sequence and by using specific antisera. Overlapping subgenic tcn alpha fragments were isolated and subsequently the total sequence of tcn alpha was determined. The 6534 nucleotide open reading frame encodes a polypeptide of M(r) 250,166 and pI 5.9. The N-terminal alpha-toxin (Tcn alpha) sequence MLITREQLMKIASIP determined by Edman degradation confirmed the identity of the reading frame and the assignment of the translation start point. The toxin is not modified posttranslationally at its N-terminus nor does it co…
Autonomic Brokerage Service for an End-to-End Cloud Networking Service Level Agreement
2014
8 pages; International audience; Today, cloud networking which is the ability to connect the user with his cloud services and to interconnect these services within an inter-cloud approach, is one of the recent research areas in the cloud computing research communities. The main drawback of cloud networking consists in the lack of Quality of Service (QoS) assurance and management in conformance with a corresponding Service Level Agreement (SLA). In this paper, we propose a framework for self-establishing an end-to-end service level agreement between a Cloud Service User (CSU) and multiple Cloud Service Providers (CSPs) in a cloud networking environment using brokerage service. We focus on Qo…
SMART: Unique splitting-while-merging framework for gene clustering
2014
© 2014 Fa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Successful clustering algorithms are highly dependent on parameter settings. The clustering performance degrades significantly unless parameters are properly set, and yet, it is difficult to set these parameters a priori. To address this issue, in this paper, we propose a unique splitting-while-merging clustering framework, named "splitting merging awareness tactics" (SMART), which does not require any a priori knowledge of either the number …
GenClust: A genetic algorithm for clustering gene expression data
2005
Abstract Background Clustering is a key step in the analysis of gene expression data, and in fact, many classical clustering algorithms are used, or more innovative ones have been designed and validated for the task. Despite the widespread use of artificial intelligence techniques in bioinformatics and, more generally, data analysis, there are very few clustering algorithms based on the genetic paradigm, yet that paradigm has great potential in finding good heuristic solutions to a difficult optimization problem such as clustering. Results GenClust is a new genetic algorithm for clustering gene expression data. It has two key features: (a) a novel coding of the search space that is simple, …