Search results for "Frame"
showing 10 items of 1767 documents
Clinical Impact of GATA2 Mutations in Acute Myeloid Leukemia Patients Harboring CEBPA Mutations: A Study of the AML Study Group (AMLSG)
2013
Abstract Background Based on their association with certain biological and clinical features as well as their prognostic significance, mutations in the CCAAT/enhancer-binding protein-alpha (CEBPA) gene have been included as a provisional entity into the 2008 World Health Organization (WHO) classification of myeloid neoplasms. CEBPA mutations (CEBPAmut) are mainly found in acute myeloid leukemia (AML) with normal cytogenetics, and approximately 60% of the mutated patients (pts) carry biallelic mutations. Several studies showed that in particular pts with double mutant CEBPA (CEBPAdm) have a favorable outcome compared to all others. Recently, mutations in the transcription factor GATA2 were i…
Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1
2006
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs). The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human Sirt1 genomic sequence, which spans a region of 33,660 bp and which has one single genomic locus. Determination of the exon-intron splice junctions established that SIRT1 is encoded by 9 exons ranging in size from 80 bp (exon 6) to 2,120 bp (exon 9). Charac…
The Open Innovation in Science research field: a collaborative conceptualisation approach
2020
Openness and collaboration in scientific research are attracting increasing attention from scholars and practitioners alike. However, a common understanding of these phenomena is hindered by disciplinary boundaries and disconnected research streams. We link dispersed knowledge on Open Innovation, Open Science, and related concepts such as Responsible Research and Innovation by proposing a unifying Open Innovation in Science (OIS) Research Framework. This framework captures the antecedents, contingencies, and consequences of open and collaborative practices along the entire process of generating and disseminating scientific insights and translating them into innovation. Moreover, it elucidat…
Molecular Characterization of the Leucine Plasmid from Buchnera aphidicola , Primary Endosymbiont of the Aphid Acyrthosiphon pisum
2000
The complete sequence of the leucine plasmid of Buchnera aphidicola from the aphid Acyrthosiphon pisum (pLeu-BAp) is reported. Its gene organization was concordant with those of other leucine plasmids of Buchnera from aphids of the Aphidini and Macrosiphini tribes. Three inverted repeats are present in pLeu-BAp. Two of them are also present in pLeu from the family Aphididae: (i) SIR1, located downstream the leucine operon, resembles a rho-independent terminator of transcription, and (ii) LIR1, located upstream of the leucine operon, is suggested to be involved in transcription termination or messenger stability. The third, located near the putative ATGC repeats involved in the origin of rep…
Single-shot digital holography by use of the fractional Talbot effect
2009
We present a method for recording in-line single-shot digital holograms based on the fractional Talbot effect. In our system, an image sensor records the interference between the light field scattered by the object and a properly codified parallel reference beam. A simple binary two-dimensional periodic grating is used to codify the reference beam generating a periodic three-step phase distribution over the sensor plane by fractional Talbot effect. This provides a method to perform single-shot phase-shifting interferometry at frame rates only limited by the sensor capabilities. Our technique is well adapted for dynamic wavefront sensing applications. Images of the object are digitally recon…
Iterative Optimal Design of Special Moment Resisting Devices for Steel Frames
2021
Abstract The present paper proposes an iterative procedure devoted to reaching the optimal design of an innovative, recently proposed, moment resisting device. This special device, called Limited Resistance Plastic Device (LRPD), can be utilized, as an example, to equip a steel frame when it is required that the frame must be designed to substitute a masonry panel, i.e., it must be characterized by a structural behaviour as close as possible to the one of the replaced masonry wall. This purpose can be reached by designing the relevant frame imposing appropriate constraints on the elastic stiffness and on the limit resistance. The result can be obtained just by ensuring that the elastic stif…
Optimal Design of New Steel Connections
2018
The Limited Resistance Rigid Perfectly Plastic Hinge (LRPH) are special steel connections mainly usable to join beam elements of plane or spatial steel frames. The fundamental characteristics of these devices are the mutual independence of their own resistance and stiffness features as well as the respect of assigned constraints related to the elastic and limit behaviour of the joined elements. Within the frame structural scheme, the device plays the role of a rigid perfectly plastic hinge, constituted by a suitably sized sandwich section. The efficient use of the LRPH in the relevant frame depends on the appropriate design of the device geometry. In the present paper, a new approach devote…
OPTIMUM DESIGN OF REINFORCED CONCRETE STRUCTURES UNDER VARIABLE LOADINGS
1987
Abstract This paper presents a method for optimal design of reinforced concrete (RC) structures, subjected to quasi-static variable loads and accounting for cross-sections limited ductility requirements. It consists of a very simple refinement procedure to be applied in the classical Optimal Shakedown Design, (OSD), which leads to a strengthened structure satisfying the requisite that the actual plastic relative rotations, developed at a specified set of critical sections as a result of a variable repeated loading program, do not exceed given upper limits. This strengthened design is a safe but not strictly optimal design and is obtained using the simple rule that the steel reinforcement ar…
Optimal design of elastic plastic frames accounting for seismic protection devices
2013
The optimal design of elastic perfectly plastic steel frames with or without suitable protection devices and subjected to static as well as seismic loadings is studied. Two minimum volume problem formulations are proposed, on the grounds of the so-called statical approach, accounting for three different resistance limits: the purely elastic limit, the (elastic) shakedown limit and the instantaneous collapse limit. The adopted load combinations are characterized by the presence of fixed loads, of quasi-static perfect cyclic loads and dynamic (seismic) loads. The linear elastic effects of the dynamic actions are studied by utilizing a modal technique. The proposed treatment is referred to the…
A multicriterion design of steel frames with shakedown constraints
2006
The minimum volume design of elastic perfectly plastic steel frames subjected to fixed and cyclic loads is searched in such a way that the structure remains in elastic field in serviceability conditions, while it is subjected to alternating plasticity under very strong cyclic actions, incremental and instantaneous collapse being prevented. The problem is faced on the grounds of a statical and a kinematical approach. The Kuhn-Tucker conditions of the two problems prove that they are each one the dual of the other and provide useful pieces of information about the structural behaviour. Numerical applications confirm the theoretical expectations: optimal designs turn out to be quite light, wit…