Search results for "Function"

Divario territoriale, coesione sociale e tutela dei diritti: il ruolo delle regioni in tempo di crisi

2021

L���articolo si occupa di verificare il ruolo delle regioni in tempo di crisi, finanziaria prima e sanitaria oggi, sia con riferimento alla gestione dell���emergenza pandemica, sia con riguardo alla gestione dei fondi del PNRR, in funzione del difficile tentativo di superare il divario territoriale, e in particolare il divario Nord-Sud, a garanzia di una maggiore protezione dei diritti delle autonomie e dunque della persona.

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

2021

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds of genes. However, mis-splicing does not satisfactorily explain muscle atrophy and wasting, and several other contributing factors have been suggested, including hyperactivated autophagy leading to excessive catabolism. MicroRNA ( miR ) -7 has been demonstrated to be necessary and sufficient to repress the autophagy pathway in cell models of the disease, but the origin of its low levels in DM1 was…

Production of Functional Crackers Enriched with Olive (Olea europaea L.) Leaf Extract

2016

In recent years, considerable interest has been shown in the functional properties of foods, and a relevant role has been played by phenolic compounds, able to scavenge free radicals. A more sustainable agriculture has to emerge to guarantee food supply over the next years. Wheat, corn, and rice are the most common cereals cultivated, but also other cereal species, such as barley can be appreciated for their peculiarities. Barley (Hordeum vulgare L.) is a C3 winter cereal that shows high resistance at drought and salt stresses. There are growing interests in barley as ingredient for the production of functional foods due to its high content of phenolic compounds and Beta-glucans. In this re…

A simulation function approach for best proximity point and variational inequality problems

2017

We study sufficient conditions for existence of solutions to the global optimization problem min(x is an element of A) d(x, fx), where A, B are nonempty subsets of a metric space (X, d) and f : A -> B belongs to the class of proximal simulative contraction mappings. Our results unify, improve and generalize various comparable results in the existing literature on this topic. As an application of the obtained theorems, we give some solvability theorems of a variational inequality problem.

Analysis of industry 4.0 implementation in mobility sector: An integrated approach based on QFD, BWM, and stratified combined compromise solution und…

2022

Journal of industrial integration 30, 100406 (2022). doi:10.1016/j.jii.2022.100406 special issue: "Data/Information Integration Techniques in Industry 4.0/5.0 / Edited by Shahid Mumtaz, Syed Hassan, Mohsen Guizani, Muhammad Ikram"

Understanding the Role of Sensorimotor Beta Oscillations

2021

Beta oscillations have been predominantly observed in sensorimotor cortices and basal\ud ganglia structures and they are thought to be involved in somatosensory processing\ud and motor control. Although beta activity is a distinct feature of healthy and pathological\ud sensorimotor processing, the role of this rhythm is still under debate. Here we review\ud recent findings about the role of beta oscillations during experimental manipulations (i.e.,\ud drugs and brain stimulation) and their alteration in aging and pathology. We show how\ud beta changes when learning new motor skills and its potential to integrate sensory input\ud with prior contextual knowledge. We conclude by discussing a n…

An impaired alveolar-capillary barrier in vitro : effect of proinflammatory cytokines and consequences on nanocarrier interaction.

2009

The alveolar region of the lung is an important target for drug and gene delivery approaches. Treatment with drugs is often necessary under pathophysiological conditions, in which there is acute inflammation of the target organ. Therefore, in vitro models of the alveolar-capillary barrier, which mimic inflammatory conditions in the alveolar region, would be useful to analyse and predict effects of novel drugs on healthy or inflamed tissues. The epithelial cell line H441 was cultivated with primary isolated human pulmonary microvascular endothelial cells (HPMECs) or the endothelial cell line ISO-HAS-1 on opposite sides of a permeable filter support under physiological and inflammatory condi…

Cluster priors in the Bayesian modelling of fMRI data

2001

Strategies to Improve the Potential Functionality of Fruit-Based Fermented Beverages

2021

It is only recently that fermentation has been facing a dynamic revival in the food industry. Fermented fruit-based beverages are among the most ancient products consumed worldwide, while in recent years special research attention has been granted to assess their functionality. This review highlights the functional potential of alcoholic and non-alcoholic fermented fruit beverages in terms of chemical and nutritional profiles that impact on human health, considering the natural occurrence and enrichment of fermented fruit-based beverages in phenolic compounds, vitamins and minerals, and pro/prebiotics. The health benefits of fruit-based beverages that resulted from lactic, acetic, alcoholic…

Antioxidative effects of cactus pear (Opuntia ficus indica, L. Mill.) fruits from Sicily and bioavailability of betalain components in healthy humans

2009

Aerobic life is characterised by a steady formation of pro-oxidants, which is approximately balanced by antioxidant defense systems. When cell’s capacity to protect itself fails, oxidative stress occurs. Because of bioactive components vegetables are now considered helpful in preventing chronic pathologies in which oxidative damage is an important etiologic factor. Cactus pear (Opuntia ficus-indica) fruit contains substantial amounts of vitamin C, biothiols, and taurine, and redox-active betalain pigments. It has been shown that a short-term supplementation (500 g fruit pulp daily, 2 wk) positively affected the body’s redox balance, decreased lipid oxidation, and improved antioxidant status…