Search results for "Functional analysis"
showing 10 items of 1059 documents
In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution
2017
The role of clonal complexity has gradually been accepted in infection by Mycobacterium tuberculosis (MTB), although analyses of this issue are limited. We performed an in-depth study of a case of recurrent MTB infection by integrating genotyping, whole genome sequencing, analysis of gene expression and infectivity in in vitro and in vivo models. Four different clonal variants were identified from independent intrapatient evolutionary branches. One of the single-nucleotide polymorphisms in the variants mapped in mce3R, which encodes a repressor of an operon involved in virulence, and affected expression of the operon. Competitive in vivo and in vitro co-infection assays revealed higher infe…
Quantum field inspired model of decision making: Asymptotic stabilization of belief state via interaction with surrounding mental environment
2018
This paper is devoted to justification of quantum-like models of the process of decision making based on the theory of open quantum systems, i.e. decision making is considered as decoherence. This process is modeled as interaction of a decision maker, Alice, with a mental (information) environment ${\cal R}$ surrounding her. Such an interaction generates "dissipation of uncertainty" from Alice's belief-state $\rho(t)$ into ${\cal R}$ and asymptotic stabilization of $\rho(t)$ to a steady belief-state. The latter is treated as the decision state. Mathematically the problem under study is about finding constraints on ${\cal R}$ guaranteeing such stabilization. We found a partial solution of th…
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets
2018
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression of some surface antigens, mainly CD14 and CD16. These cells are key players in the inflammation process underlying the mechanism of many diseases. Thus, the molecular characterization of these cells may provide very useful information for understanding their biology in health and disease. We performed a multicentric proteomic study with pure classical and non-classical populations derived from 12 healthy donors. The robust workflow used provided reproducible results among t…
Space-filling vs. Luzin's condition (N)
2013
Let us assume that we are given two metric spaces, where the Hausdorff dimension of the first space is strictly smaller than the one of the second space. Suppose further that the first space has sigma-finite measure with respect to the Hausdorff measure of the corresponding dimension. We show for quite general metric spaces that for any measurable surjection from the first onto the second space, there is a set of measure zero that is mapped to a set of positive measure (both measures are the Hausdorff measures corresponding to the Hausdorff dimension of the first space). We also study more general situations where the measures on the two metric spaces are not necessarily the same and not ne…
Isometric embeddings of snowflakes into finite-dimensional Banach spaces
2016
We consider a general notion of snowflake of a metric space by composing the distance by a nontrivial concave function. We prove that a snowflake of a metric space $X$ isometrically embeds into some finite-dimensional normed space if and only if $X$ is finite. In the case of power functions we give a uniform bound on the cardinality of $X$ depending only on the power exponent and the dimension of the vector space.
Frame-related Sequences in Chains and Scales of Hilbert Spaces
2022
Frames for Hilbert spaces are interesting for mathematicians but also important for applications in, e.g., signal analysis and physics. In both mathematics and physics, it is natural to consider a full scale of spaces, and not only a single one. In this paper, we study how certain frame-related properties of a certain sequence in one of the spaces, such as completeness or the property of being a (semi-) frame, propagate to the other ones in a scale of Hilbert spaces. We link that to the properties of the respective frame-related operators, such as analysis or synthesis. We start with a detailed survey of the theory of Hilbert chains. Using a canonical isomorphism, the properties of frame se…
Frames and weak frames for unbounded operators
2020
In 2012 G\u{a}vru\c{t}a introduced the notions of $K$-frame and of atomic system for a linear bounded operator $K$ in a Hilbert space $\mathcal{H}$, in order to decompose its range $\mathcal{R}(K)$ with a frame-like expansion. In this article we revisit these concepts for an unbounded and densely defined operator $A:\mathcal{D}(A)\to\mathcal{H}$ in two different ways. In one case we consider a non-Bessel sequence where the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the norm of $\mathcal{H}$. In the other case we consider a Bessel sequence and the coefficient sequence depends continuously on $f\in\mathcal{D}(A)$ with respect to the graph norm of $A$.
Hilbert space operators with two-isometric dilations
2021
A bounded linear Hilbert space operator $S$ is said to be a $2$-isometry if the operator $S$ and its adjoint $S^*$ satisfy the relation $S^{*2}S^{2} - 2 S^{*}S + I = 0$. In this paper, we study Hilbert space operators having liftings or dilations to $2$-isometries. The adjoint of an operator which admits such liftings is characterized as the restriction of a backward shift on a Hilbert space of vector-valued analytic functions. These results are applied to concave operators (i.e., operators $S$ such that $S^{*2}S^{2} - 2 S^{*}S + I \le 0$) and to operators similar to contractions or isometries. Two types of liftings to $2$-isometries, as well as the extensions induced by them, are construct…
Group topologies coarser than the Isbell topology
2011
Abstract The Isbell, compact-open and point-open topologies on the set C ( X , R ) of continuous real-valued maps can be represented as the dual topologies with respect to some collections α ( X ) of compact families of open subsets of a topological space X . Those α ( X ) for which addition is jointly continuous at the zero function in C α ( X , R ) are characterized, and sufficient conditions for translations to be continuous are found. As a result, collections α ( X ) for which C α ( X , R ) is a topological vector space are defined canonically. The Isbell topology coincides with this vector space topology if and only if X is infraconsonant. Examples based on measure theoretic methods, t…
Non-autonomous rough semilinear PDEs and the multiplicative Sewing Lemma
2021
We investigate existence, uniqueness and regularity for local solutions of rough parabolic equations with subcritical noise of the form $du_t- L_tu_tdt= N(u_t)dt + \sum_{i = 1}^dF_i(u_t)d\mathbf X^i_t$ where $(L_t)_{t\in[0,T]}$ is a time-dependent family of unbounded operators acting on some scale of Banach spaces, while $\mathbf X\equiv(X,\mathbb X)$ is a two-step (non-necessarily geometric) rough path of H\"older regularity $\gamma >1/3.$ Besides dealing with non-autonomous evolution equations, our results also allow for unbounded operations in the noise term (up to some critical loss of regularity depending on that of the rough path $\mathbf X$). As a technical tool, we introduce a versi…