Search results for "G2"

showing 10 items of 439 documents

Notations et écarts de rentabilité : le marché français avant l'euro

2003

The main task of this paper is to confront two classical measures of default risk of the issuer, the rating and the spread. The first is attributed by agencies specialized in this activity (Standard and Poor's or Moody's) while the second results directly from the market price of the bond. This article studies this link over a period of two years for about forty French denominated bonds. Two measures of the spread are used and the results obtained show the very partial consideration of this information by the investors on the French bond market.

default riskbondsJEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G24 - Investment Banking • Venture Capital • Brokerage • Ratings and Ratings AgenciesJEL: G - Financial Economics/G.G1 - General Financial Markets/G.G1.G10 - Generalspreadratingjel:G10notationJEL : G - Financial Economics/G.G1 - General Financial Markets/G.G1.G10 - Generalobligations;spread de taux;notation;risque de défautbonds; spread;rating;default risk.risque de défaut.[SHS.GESTION]Humanities and Social Sciences/Business administrationspread de tauxJEL : G - Financial Economics/G.G1 - General Financial Markets/G.G1.G12 - Asset Pricing • Trading Volume • Bond Interest Rates[SHS.GESTION] Humanities and Social Sciences/Business administration[ SHS.GESTION ] Humanities and Social Sciences/Business administrationJEL : G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G24 - Investment Banking • Venture Capital • Brokerage • Ratings and Ratings AgenciesJEL: G - Financial Economics/G.G1 - General Financial Markets/G.G1.G12 - Asset Pricing • Trading Volume • Bond Interest Ratesobligations
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Cytotoxic effects of individual and combined sterigmatocystin and nivalenol on liver hepatocellular carcinoma cells

2020

Abstract Since humans are exposed to different mycotoxins through daily intake, there is increasing concern about the adverse effects of the interactions between them. Cytotoxicity of sterigmatocystin (STE) and nivalenol (NIV) alone and in combination in human hepatocarcinoma (HepG2) cells was evaluated by MTT assay. Furthermore, ROS production and alteration of ΔΨm as mechanisms of action were assessed. Cells were treated with concentrations ranging from 0.15 to 5 μM for NIV and from 0.78 to 50 μM for STE individually and in binary combinations. The combination ratio between the mixture STE + NIV was 10:1. The IC50 values of NIV ranged from 0.96 to 0.66 μM, whereas no IC50 values were obta…

endocrine systemCarcinoma HepatocellularSterigmatocystinAntineoplastic AgentsPharmacologyToxicology03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologyIc50 valuesmedicineHumansCytotoxic T cellMTT assayCytotoxicityMycotoxinAdverse effect030304 developmental biology0303 health sciencesMolecular StructureLiver NeoplasmsDrug SynergismHep G2 Cells04 agricultural and veterinary sciencesGeneral Medicinemedicine.disease040401 food sciencechemistryHepatocellular carcinomaTrichothecenesFood ScienceSterigmatocystinFood and Chemical Toxicology
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The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis

2021

Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…

endometriosisTHP-1 CellsTNF-amast cellsPeritoneal DiseasesCell DegranulationEndometriumImmunology and AllergyOriginal ResearchMice Knockoutmedicine.diagnostic_testendometriosiComplement C3Hep G2 CellsAntibody opsonizationmedicine.anatomical_structureComplement C3aTumor necrosis factor alphaFemaleInflammation MediatorsSignal TransductionImmunologyBiologySettore MED/08 - Anatomia PatologicaImmunofluorescencePeritoneal cavityPeritoneummedicineAnimalsHumansSettore MED/05 - Patologia ClinicaC3complement system...Innate immune systemTumor Necrosis Factor-alphaPeritoneal fluidC3; endometriosis; mast cells; complement system; TNF-aRC581-607Coculture TechniquesImmunity InnateComplement systemImmunity HumoralMice Inbred C57BLDisease Models AnimalCase-Control StudiesTNF-αCancer researchPeritoneal DiseaseImmunologic diseases. Allergymast cell
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Fonds de retraite et performance : la famille compte-t-elle ?

2008

(VF)Actuellement, la majorité des fonds mutuels ou des fonds de pension appartient à une famille. Une famille comprend les fonds gérés par la même société. Cet article s’intéresse à la performance des fonds de pension anglais à cotisations définies sur longue période. La performance est mesurée du point de vue de la famille de fonds. Ce changement de niveau d’analyse amène à s’interroger sur l’influence de la taille et donc de la complexité organisationnelle des sociétés de gestion de portefeuille sur leur performance. Autrement dit, les petites familles présentent-elles des performances supérieures à celles des grandes familles? (VA)Almost all mutual funds or pension funds belong to a fami…

famillefamilyfonds;performance;famille;organisation;complexité;funds;performance;family;organization;complexity.organisationpension fundsorganizationjel:G23complexitéjel:G10funds familyfonds[SHS.GESTION]Humanities and Social Sciences/Business administration[SHS.GESTION] Humanities and Social Sciences/Business administration[ SHS.GESTION ] Humanities and Social Sciences/Business administrationperformance
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Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal…

2011

In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects …

food.ingredientAlpinia galangagastrointestinal tumorsTrypanosoma brucei bruceiSelaginella tamariscinaPharmacologyHedyotis diffusaPhytomedicinetraditional Chinese medicinefoodHepG2 2.2.15Panax notoginsenglcsh:QH301-705.5BVDVNature and Landscape ConservationKadsura longipedunculataEcologybiologyEcological ModelingCoptis chinensisbiology.organism_classificationAgricultural and Biological Sciences (miscellaneous)Houttuynia cordataanticancer drugs; gastrointestinal tumors; traditional Chinese medicine; cytotoxicity; hepatitis B; hepatitis C; HepG2 2.2.15; BVDV; <em>Trypanosoma brucei brucei</em>anticancer drugslcsh:Biology (General)cytotoxicityhepatitis Bhepatitis CDiversity
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Saturated and unsaturated free fatty acids (FFA) modulate differently HDL uptake in hepatoma HEPG2 cells

2003

free fatty acids HDL HEPG2 cells
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"Table 3" of "Cross section and longitudinal single-spin asymmetry $A_L$ for forward $W^{\pm}\rightarrow\mu^{\pm}\nu$ production in polarized $p$$+$$…

2023

Single-spin asymmetries at forward $A^{FW}_L$ and backward $A^{BW}_L$ rapidities for $p$+$p$ collisions at $\sqrt{s}$ = 510 GeV for results in 2013 and 2012, plus combined results for both years.

helicities$p$ $p$ --&gt; $\mu^\pm$ + Xcross sectionsingle-spin asymmetry$p$ $p$ --&gt; $W^\pm$ + Xppg214510.0
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"Conclusion" of "Cross section and longitudinal single-spin asymmetry $A_L$ for forward $W^{\pm}\rightarrow\mu^{\pm}\nu$ production in polarized $p$$…

2023

The total $W$ boson production cross sections for $p$+$p$ collisions at $\sqrt{s}$ = 510 GeV for $\sigma$($W^+$ $\rightarrow$ $\mu^+$) and $\sigma$($W^-$ $\rightarrow$ $\mu^-$).

helicities$p$ $p$ --&gt; $\mu^\pm$ + Xcross sectionsingle-spin asymmetry$p$ $p$ --&gt; $W^\pm$ + Xppg214510.0
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Dose calculation in biological samples in a mixed neutron-gamma field at the TRIGA reactor of the University of Mainz

2010

To establish Boron Neutron Capture Therapy (BNCT) for non-resectable liver metastases and for in vitro experiments at the TRIGA Mark II reactor at the University of Mainz, Germany, it is necessary to have a reliable dose monitoring system. The in vitro experiments are used to determine the relative biological effectiveness (RBE) of liver and cancer cells in our mixed neutron and gamma fi eld. We work with alanine detectors in combination with Monte Carlo simulations, where we can measure and characterize the dose. To verify our calculations we perform neutron fl ux measurements using gold foil activation and pin-diodes . Material and methods . When L- α -alanine is irradiated with ionizing …

inorganic chemicalsPhysics::Instrumentation and DetectorsQuantitative Biology::Tissues and OrgansPhysics::Medical PhysicsBoron Neutron Capture TherapyValidation Studies as TopicModels BiologicalIonizing radiationTRIGAHospitals UniversityNuclear ReactorsCell Line TumorGermanyRelative biological effectivenessMedicineDosimetryHumansRadiology Nuclear Medicine and imagingNeutronNeutronsbusiness.industryRadiotherapy Planning Computer-AssistedRadiochemistryLiver NeoplasmsRadiotherapy DosageHematologyGeneral MedicineHep G2 CellsNeutron temperatureNeutron captureOncologyGamma RaysAbsorbed dosebusinessNuclear medicineColorectal Neoplasms
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Ksenobiotiku metabolisma enzīmu citohroma P450 aktivitātes audzēju šūnu līnijās

2017

Jaunu zāļu vielu meklējumi pasaulē notiek ļoti aktīvi. Šobrīd jauno savienojumu īpašību, tai skaitā toksiskuma, izpētei plaši izmanto šūnu līniju modeļus in vitro. Viena no šūnu svarīgākajām sistēmām, kurai ir milzīga ietekme uz jebkura preparāta darbību organismā, ir citohroma P450 sistēma. Tai ir svarīga loma ķīmiskās homeostāzes uzturēšanā organismā gan fozioloģiskos, gan pataloģiskos apstākļos. Citohromi piedalās ļoti daudzu ksenobiotiķu eliminācijā no šūnām. Turklāt, zinot, ka ksenobiotiķu biotransformācijas procesā var veidoties organismam bīstami toksiski metabolīti, zināšanas par citohromu aktivitāti kļūst īpaši svarīgas. Šī darba mērķis ir citohroma P450 sistēmas raksturojums šūnu …

izoformu aktivitātezāļu skrīningsSHSY5Y сilvēka neiroblastomaHepG2 cilvēka hapatocītu karcinomacitohroms P450Bioloģija
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