Search results for "G3P"

showing 6 items of 6 documents

Unusual Assortment of Segments in 2 Rare Human Rotavirus Genomes

2010

Using full-length genome sequence analysis, we investigated 2 rare G3P[9] human rotavirus strains isolated from children with diarrhea. The genomes were recognized as assortments of genes closely related to rotaviruses originating from cats, ruminants, and humans. Results suggest multiple transmissions of genes from animal to human strains of rotaviruses.

DiarrheaMicrobiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaSettore MED/17 - Malattie InfettiveEpidemiologySequence analysisvirusesMolecular Sequence DataReassortmentlcsh:Medicineinterspecies transmissionGenome ViralBiologymedicine.disease_causeGenomeRotavirus Infectionslcsh:Infectious and parasitic diseasesfluids and secretionsPhylogeneticsRotavirusfull genome sequencingmedicineG3P[9]Humanslcsh:RC109-216GeneGenotypingPhylogenyWhole genome sequencingGeneticsSequence Analysis RNAlcsh:RDispatchvirus diseasesVirologyGastroenteritiszoonosesInfectious Diseasesrotavirushuman rotavirugenotypingChild PreschoolVirusesRNA ViralreassortmentgenomesSequence AlignmentEmerging Infectious Diseases
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Enhanced Solar Light Photocatalytic Activity of Ag Doped TiO2–Ag3PO4 Composites

2020

Composites comprised of Ag3PO4 and bare TiO2 (TiO2@Ag3PO4) or silver doped TiO2 (Ag@TiO2&ndash

Materials scienceDiffuse reflectance infrared fourier transformheterojunction4–nitrophenol degradationScanning electron microscope3General Chemical Engineering42Sol-gel synthesisInfrared spectroscopyAg@TiO2–Ag3PO4 heterojunctionPOArticlelcsh:Chemistrysolar photocatalysissol–gel synthesisSpecific surface areaGeneral Materials ScienceComposite materialFourier transform infrared spectroscopyPrecipitation (chemistry)4-nitrophenol degradationAg@TiODoping4-nitrophenol degradation; Ag@TiO; 2; -Ag; 3; PO; 4; heterojunction; Sol-gel synthesis; Solar photocatalysis-Aglcsh:QD1-999Solar photocatalysisPhotocatalysisAg@TiO<sub>2</sub>–Ag<sub>3</sub>PO<sub>4</sub> heterojunctionNanomaterials
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Canine-Origin G3P[3] Rotavirus Strain in Child with Acute Gastroenteritis

2007

Infection by an animal-like strain of rotavirus (PA260/97) was diagnosed in a child with gastroenteritis in Palermo, Italy, in 1997. Sequence analysis of VP7, VP4, VP6, and NSP4 genes showed resemblance to a G3P[3] canine strain identified in Italy in 1996. Dogs are a potential source of human viral pathogens.

RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaDisease reservoircanine rotavirusEpidemiologyvirusesSequence Homologylcsh:Medicinemedicine.disease_causePolymerase Chain Reactionlaw.inventionfluids and secretionslawZoonosesRotavirushuman rotavirusGenotypePotential sourceDog DiseasesRotavirusG3P[3] VP7 VP4PhylogenyPolymerase chain reactionStrain (chemistry)Dispatchvirus diseasesGastroenteritisVP7Infectious DiseasesChild PreschoolVP4Acute DiseaseVP6Microbiology (medical)GenotypeNSP4Sequence analysisBiologyRotavirus Infectionslcsh:Infectious and parasitic diseasesMicrobiologyDogsSpecies SpecificitymedicineAnimalsHumanslcsh:RC109-216G3P[3] genotypeDisease Reservoirslcsh:RAcute gastroenteritisVirologyEmerging Infectious Diseases
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Emergence in 2017-2019 of novel reassortant equine-like G3 rotavirus strains in Palermo, Sicily.

2021

Rotavirus A (RVA) is a major etiologic agent of gastroenteritis in children worldwide. Hospital-based surveillance of viral gastroenteritis in paediatric population in Palermo (Italy) from 2017 onwards revealed a sharp increase in G3P[8] RVAs, accounting for 71% of all the RVAs detected in 2019. This pattern had not been observed before in Italy, with G3 RVA usually being detected at rates lower than 3%. In order to investigate this unique epidemiological pattern, the genetic diversity of G3 RVAs identified during a 16-year long surveillance (2004-2019) was explored by systematic sequencing of the VP7 and VP4 genes and by whole genome sequencing of selected G3 strains, representative of the…

RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaGenotype040301 veterinary sciencesvirusesGenome ViralBiologymedicine.disease_causeGenomeRotavirus Infections0403 veterinary science03 medical and health sciencesHuman healthRotavirusmedicineAnimalsHumansHorsesGeneSicilyPhylogeny030304 developmental biologyWhole genome sequencingacute gastroenteritis DS-1 like genetic backbone equine-like G3P[8] Italy rotaviruswhole genome sequencing0303 health sciencesGenetic diversityGeneral VeterinaryGeneral Immunology and MicrobiologyPhylogenetic treevirus diseases04 agricultural and veterinary sciencesGeneral MedicineVirologyHorse DiseasesReassortant VirusesPaediatric populationTransboundary and emerging diseasesREFERENCES
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Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993–2005

2009

International audience; In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6 and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4 and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.

RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaSettore MED/17 - Malattie InfettiveSequence analysisNSP4virusesMolecular Sequence DataReoviridaeViral Nonstructural ProteinsBiologymedicine.disease_causeRotavirus InfectionsVirusFeces03 medical and health sciencesfluids and secretionsViral geneticsPhylogeneticsVirologyRotavirusGenotypemedicineHumansAmino Acid SequenceAntigens ViralGenePhylogenyGlycoproteinsToxins Biological030304 developmental biology0303 health sciencesSequence Analysis RNA030306 microbiologyInfant NewbornInfantvirus diseasesbiology.organism_classificationVirologyInfectious DiseasesItalyChild PreschoolRNA ViralMedicineCapsid Proteinssequence analysirotavirus G3P[8]gastroenteriti
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