6533b858fe1ef96bd12b590b
RESEARCH PRODUCT
Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993–2005
Antonio CascioSerenella AristaVito MartellaClaudia ColombaGiovanni M. GiammancoSimona De Graziasubject
RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaSettore MED/17 - Malattie InfettiveSequence analysisNSP4virusesMolecular Sequence DataReoviridaeViral Nonstructural ProteinsBiologymedicine.disease_causeRotavirus InfectionsVirusFeces03 medical and health sciencesfluids and secretionsViral geneticsPhylogeneticsVirologyRotavirusGenotypemedicineHumansAmino Acid SequenceAntigens ViralGenePhylogenyGlycoproteinsToxins Biological030304 developmental biology0303 health sciencesSequence Analysis RNA030306 microbiologyInfant NewbornInfantvirus diseasesbiology.organism_classificationVirologyInfectious DiseasesItalyChild PreschoolRNA ViralMedicineCapsid Proteinssequence analysirotavirus G3P[8]gastroenteritidescription
International audience; In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6 and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4 and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-11-04 |