Search results for "GALA"

A new sample of large angular size radio galaxies

2004

We present in this paper a detailed study of a new sample of large angular size FR I and FR II radio galaxies and compare the properties of the two classes. As expected, a pure morphology based distinction of FR Is and FR IIs corresponds to a break in total radio power. The radio cores in FR Is are also weaker than in FR IIs, although there is not a well defined break power. We find that asymmetry in the structure of the sample members must be the consequence of anisotropies in the medium where the lobes expand, with orientation playing a minor role. Moreover, literature data and our observations at kiloparsec scales suggest that the large differences between the structures of FR I and FR I…

Correlation of the highest-energy cosmic rays with nearby extragalactic objects.

2007

Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar…

Long-term monitoring of mrk 501 for its very high energy γ emission and a flare in 2011 october

2012

"As one of the brightest active blazars in both X-ray and very high energy γ -ray bands, Mrk 501, is very useful for" "physics associated with jets from active galactic nuclei. The ARGO-YBJ experiment has monitored Mrk 501 for γ - rays above 0.3 TeV since 2007 November. The largest flare since 2005 was observed from 2011 October and lasted until about 2012 April. In this paper, a detailed analysis of this event is reported. During the brightest γ -ray flaring episodes from 2011 October 17 to November 22, an excess of the event rate over 6σ is detected by ARGO-YBJ in the direction of Mrk 501, corresponding to an increase of the γ -ray flux above 1 TeV by a factor of 6.6 ± 2.2 from its steady…

Dissipative Processes and Their Role in the Evolution of Radio Galaxies

2019

Particle acceleration in relativistic jets to very high energies occurs at the expense of the dissipation of magnetic or kinetic energy. Therefore, understanding the processes that can trigger this dissipation is key to the characterization of the energy budgets and particle acceleration mechanisms at action in active galaxies. Instabilities and entrainment are two obvious candidates to trigger dissipation. On the one hand, supersonic, relativistic flows threaded by helical fields, as expected from the standard formation models of jets in supermassive black-holes, are unstable to a series of magnetohydrodynamical instabilities, such as the Kelvin-Helmholtz, current-driven, or possibly the p…

REM near-IR and optical multiband observations of PKS 2155-304 in 2005 : Erratum

2007

Fernandez Soto, Alberto, Alberto.Fernandez@uv.es

Phenotype determining alleles in GM1 gangliosidosis patients bearing novel GLB1 mutations.

2010

Hofer D, Paul K, Fantur K, Beck M, Roubergue A, Vellodi A, Poorthuis BJ, Michelakakis H, Plecko B, Paschke E. Phenotype determining alleles in GM1 gangliosidosis patients bearing novel GLB1 mutations. GM1 gangliosidosis manifests with progressive psychomotor deterioration and dysostosis of infantile, juvenile, or adult onset, caused by alterations in the structural gene coding for lysosomal acid s-galactosidase (GLB1). In addition, allelic variants of this gene can result in Morquio B disease (MBD), a phenotype with dysostosis multiplex and entire lack of neurologic involvement. More than 100 sequence alterations in the GLB1 gene have been identified so far, but only few could be proven to …

Mutational analysis of 105 mucopolysaccharidosis type VI patients

2007

Mucopolysaccharidosis type VI (MPS VI; Maroteaux-Lamy syndrome) is a lysosomal storage disorder caused by mutations in the N-acetylgalactosamine-4-sulfatase (arylsulfatase B, ARSB) gene. ARSB is a lysosomal enzyme involved in the degradation of the glycosaminoglycans (GAG) dermatan and chondroitin sulfate. ARSB mutations reduce enzyme function and GAG degradation, causing lysosomal storage and urinary excretion of these partially degraded substrates. Disease onset and rate of progression is variable, producing a spectrum of clinical presentation. In this study, 105 MPS VI patients—representing about 10% of the world MPS VI population—were studied for molecular genetic and biochemical parame…

[Fabry disease in Italy: first epidemiologic and collaborative study].

2005

The authors sought to define the prevalence of Fabry disease and to establish the incidence and its natural history in Italy. The aim of this study was to point out the first clinical signs and symptoms to perform an early diagnosis and hence to start a specific therapeutic treatment. Fabry disease is an inborn error of metabolism caused by the deficiency of the lysosomal enzyme alpha-galactosidase A. Fabry disease is a severe X-linked disorder presenting with a higher morbidity between the third and the fourth decade of life. Fabry disease may be confused with other diseases or completely misdiagnosed: its frequency is estimated worldwide to be 1:117000. In Italy, 65 patients have been ide…

Galactose increase in an infant whose mother is heterozygous for peripheral uridine diphosphate galactose‐4‐epimerase deficiency

1991

Selective expression of galanin in neuronal-like cells of the human carotid body

2015

The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human.…