Search results for "GATE"
showing 10 items of 1811 documents
Simulation of many-qubit quantum computation with matrix product states
2006
Matrix product states provide a natural entanglement basis to represent a quantum register and operate quantum gates on it. This scheme can be materialized to simulate a quantum adiabatic algorithm solving hard instances of a NP-Complete problem. Errors inherent to truncations of the exact action of interacting gates are controlled by the size of the matrices in the representation. The property of finding the right solution for an instance and the expected value of the energy are found to be remarkably robust against these errors. As a symbolic example, we simulate the algorithm solving a 100-qubit hard instance, that is, finding the correct product state out of ~ 10^30 possibilities. Accum…
DOTAGA-Trastuzumab. A New Antibody Conjugate Targeting HER2/Neu Antigen for Diagnostic Purposes.
2012
International audience; Improved bifunctional chelating agents (BFC) are required for indium-111 radiolabeling of monoclonal antibodies (mAbs) under mild conditions to yield stable, target-specific agents. 2,2',2″-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (DOTAGA-anhydride) was evaluated for mAb conjugation and labeling with indium-111. The DOTA analogue was synthesized and conjugated to trastuzumab-which targets the HER2/neu receptor-in mild conditions (PBS pH 7.4, 25 °C, 30 min) and gave a mean degree of conjugation of 2.6 macrocycle per antibody. Labeling of this immunoconjugate with indium-111 was performed in 75% yield after 1 h a…
Observation of Very Narrow Linewidths in the Fluorescence Excitation Spectra of Single Conjugated Polymer Chains at 1.2 K
2007
Fluorescence emission and excitation spectra of single poly[2-methoxy-5-(2'-ethyl-hexyloxy)-1,4-phenylene vinylene] polymer molecules embedded in poly(methylmethacrylate) have been recorded at 1.2 K. The ubiquitous spectral diffusion causes large variations in the spectral shape and apparent linewidth in the emission spectra. Nevertheless, we find very narrow (approximately 0.1 cm(-1)) purely electronic zero-phonon lines in the excitation spectra, which are 2 orders of magnitude smaller than previous estimates of the homogeneous linewidth. These results complement the molecular description of the low energy transitions in conjugated polymers.
First data with the ATLAS Level-1 Calorimeter Trigger
2008
The ATLAS Level-1 Calorimeter Trigger is one of the main elements of the first stage of event selection for the ATLAS experiment at the LHC. The input stage consists of a mixed analogue/digital component taking trigger sums from the ATLAS calorimeters. The trigger logic is performed in a digital, pipelined system with several stages of processing, largely based on FPGAs, which perform programmable algorithms in parallel with a fixed latency to process about 300 Gbyte/s of input data. The real-time output consists of counts of different types of physics objects, and energy sums. The final system consists of over 300 custom-built VME modules, of several different types. The installation at AT…
Age-dependent epileptic encephalopathy associated with an unusual co-occurrence of ZEB2 and SCN1A variants.
2020
Mowat-Wilson syndrome is a genetic disorder associated with a variable phenotype including peculiar facial features associated with intellectual disability, epilepsy, language impairment, and multiple congenital anomalies caused by heterozygous mutation of the ZEB2 gene. The ZEB2 protein is a complex transcription factor that encompasses multiple functional domains that interact with the regulatory regions of target genes including those involved in brain development. Recently, it has been documented that ZEB2 regulates the differentiation of interneuron progenitors migrating from the medial ganglionic eminence to cortical layers by repression of the Nkx2-1 homeobox transcription factor. It…
Exponential and bayesian conjugate families: Review and extensions
1997
The notion of a conjugate family of distributions plays a very important role in the Bayesian approach to parametric inference. One of the main features of such a family is that it is closed under sampling, but a conjugate family often provides prior distributions which are tractable in various other respects. This paper is concerned with the properties of conjugate families for exponential family models. Special attention is given to the class of natural exponential families having a quadratic variance function, for which the theory is particularly fruitful. Several classes of conjugate families have been considered in the literature and here we describe some of their most interesting feat…
Study ofB−→DK−π+π−andB−→Dπ−π+π−decays and determination of the CKM angleγ
2015
We report a study of the suppressed B- -> DK-pi(+)pi(-) and favored B- -> D pi(-)pi(+)pi(-) decays, where the neutral D meson is detected through its decays to the K--/+pi(+/-) and CP -even K+K- and pi(+)pi(-) final states. The measurement is carried out using a proton-proton collision data sample collected by the LHCb experiment, corresponding to an integrated luminosity of 3.0 fb(-1). We observe the first significant signals in the CP - even final states of the D meson for both the suppressed B- -> DK-pi(+)pi(-) and favored B- -> D pi(-)pi(+)pi(-) modes, as well as in the doubly Cabibbo suppressed D -> K+pi(-) final state of the B- -> D pi(-)pi(+)pi(-) decay. Evidence for the suppressed d…
A Mlp-Based Digit And Uppercase Characters Recognition System
1997
A simple software solution for digit and uppercase handwritten characters recognition is presented. The proposed solution is based on a two-layer Multi Layer Perceptron (MLP) trained by a conjugate gradient descent (CGD) optimization algorithm. This neural network is embedded in a software tool for automatic processing of forms achieved using a scanner. The chosen solutions allow us to obtain good results both in terms of recognition rate and speed. In the paper are fully described design details and experimental results.
Efficient smart-camera accelerator: A configurable motion estimator dedicated to video codec
2013
Smart cameras are used in a large range of applications. Usually the smart cameras transmit the video or/and extracted information from the video scene, frequently on compressed format to fit with the application requirements. An efficient hardware accelerator that can be adapted and provide the required coding performances according to the events detected in the video, the available network bandwidth or user requirements, is therefore a key element for smart camera solutions. We propose in this paper to focus on a key part of the compression system: motion estimation. We have developed a flexible hardware implementation of the motion estimator based on FPGA component, fully compatible with…
Studies on the diurnal courses of the contents of abscisic acid, 1-aminocyclopropane carboxylic acid and its malonyl conjugate in needles of damaged …
1993
Summary The diurnal courses of the contents of 1-aminocyclopropane carboxylic acid (ACC), its malonyl conjugate (MACC) and abscisic acid (ABA) in the two-year-old needles of damaged and undamaged spruce trees (Picea abies L.) were investigated. The contents of ACC and MACC were significantly higher in the needles of the damaged trees as compared with the undamaged ones. In the needles of the damaged spruce trees, the ACC and MACC contents, and ABA contents as well, fluctuated to a greater extent than those in the undamaged spruce trees during the day. The relationships between ACC-ABA and MACC-ACC contents as well are also discussed.