Search results for "GB"

A Comparative Analysis of Different Robust Design Approaches in Sheet Stamping Operations

2011

A crucial issue in sheet stamping optimization problems is related to the process robustness improvement: critical scattering in the investigated performances arises due to some noise variables influence, often evolving up design failure itself. In fact, strong variations in the final stamped part or fluctuations of strain distribution may lead to an uncontrolled process design. Such variability cannot be controlled but anyway it is possible to develop proper design tools able to identify robust process calibrations above which the noises variations effects are admissible. In this paper, a multi‐objective optimization problem was analyzed, with the aim to minimize both excessive thinning an…

A NEW PROGRESSIVE DESIGN METHODOLOGY FOR COMPLEX SHEET METAL STAMPING OPERATIONS: COUPLING SPATIALLY DIFFERENTIATED RESTRAINING FORCES APPROACH AND M…

2010

The growing interest in sheet metal stamping processes, particularly in the automotive industry has led to three main issues in this field:*request of very complex shapes; *growing interest in springback control; *solution of multi-objective problems. These issues make a sheet metal stamping processes design very difficult and proper design methodologies to reduce times and costs are highly required. In this paper, a computer aided approach aiming to satisfy the mentioned issues is proposed. In particular, a progressive design approach based on the integration between numerical simulations, Response Surface Methodology (RSM) and Pareto optimal solutions search techniques was applied in orde…

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

2016

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and res…

Zooplankton biodiversity and community structure vary along spatiotemporal environmental gradients in restored peridunal ponds

2015

<p>Zooplankton assemblages in neighboring ponds can show important spatial and temporal heterogeneity. Disentangling the influence of regional versus local factors, and of deterministic versus stochastic processes has been recently highlighted in the context of the metacommunity theory. In this study, we determined patterns of temporal and spatial variation in zooplankton diversity along one hydrological year in restored ponds of different hydroperiod and age. The following hypotheses regarding the assembling of species over time were tested: i) dispersal is not limited in our study system due to its small area and high exposure to dispersal vectors; ii) community dissimilarity among …

Fluxon dynamics in Li–Al codoped MgB2 by microwave surface resistance measurements

2010

The magnetic-field-induced variations of the microwave surface resistance, Rs, have been investigated in ceramic Mg_(1-x)(LiAl)_xB_2, with x in the range 0.1 - 0.4. The measurements have been performed on increasing and decreasing the DC magnetic field, H0, at fixed temperatures. At low temperatures, we have observed a magnetic hysteresis in the Rs(H0) curves in all the investigated samples. On increasing the temperature, the range of H0 in which the hysteretic behavior is visible shrinks; however, in the sample with x=0.1 it is present up to temperatures close to Tc. We show that the field dependence of Rs can be quantitatively justified taking into account the critical-state effects on th…

Anomalous hysteretic behaviour of the microwave surface resistance in MgB2 superconductor

2007

Microwave response of a cylindrical cavity made of bulk MgB2 superconductor

2007

Different Scales of Spatial Segregation of Two Species of Feather Mites on the Wings of a Passerine Bird

2011

The "condition-specific competition hypothesis" proposes that coexistence of 2 species is possible when spatial or temporal variations in environmental conditions exist and each species responds differently to those conditions. The distribution of different species of feather mites on their hosts is known to be affected by intrinsic host factors such as structure of feathers and friction among feathers during flight, but there is also evidence that external factors such as humidity and temperature can affect mite distribution. Some feather mites have the capacity to move through the plumage rather rapidly, and within-host variation in intensity of sunlight could be one of the cues involved …

Evolution and genetic structure of the great tit (Parus major) complex

2003

The great tit complex is divided into four groups, each containing several subspecies. Even though the groups are known to differ markedly on morphological, vocal and behavioural characters, some hybridization occurs in the regions where they meet. The great tit has often been referred to as an example of a ring species, although this has later been questioned. Here, we have studied the genetic structure and phylogenetic relationships of the subspecies groups to clarify the evolutionary history of the complex using control region sequences of the mitochondrial DNA. The subspecies groups were found to be monophyletic and clearly distinct in mitochondrial haplotypes, and therefore must have h…

DNA minor groove binders: an overview on molecular modeling and QSAR approaches

2007

Molecular recognition of DNA by small molecules and proteins is a fundamental problem in structural biology and drug design. Understanding of recognition in both sequence-selective and sequence neutral ways at the level of successful prediction of binding modes and site selectivity will be instrumental for improvements in the design and synthesis of new molecules as potent and selective gene-regulatory drugs. Minor groove is the target of a large number of non-covalent binding agents. DNA binding with specific sequences, mostly AT, takes place by means of a combination of directed hydrogen bonding to base pair edges, van der Waals interactions with the minor groove walls and generalized ele…