Search results for "GC"

The essential oil composition of the endemic plant species Centaurea vandasii and chemotaxonomy of section Phalolepis (Asteraceae)

2021

In the present study, the chemical composition of the essential oil from aerial parts of the endemic plant species, Centaurea vandasii Velen (sect. Phalolepis, Asteraceae), collected in its locus classicus in Rhodope Mts, Bulgaria, was evaluated by GC-MS. The main components of the oil were hexadecanoic acid (18.3%), tetradecanoic acid (13.8%), caryophyllene oxide (12.1%) and germacrene D (8.4%). Furthermore, a complete literature review on the composition of the essential oils of all the other taxa of Centaurea, belonging to section Phalolepis, studied so far, was performed. HCA (Hierarchical Cluster Analysis) and PCA (Principal Component Analyses) were used in order to demonstrate chemota…

Study on the adsorption of PCBs in alginate Montmorillonite beads by GC-MS analysis

2013

Activation of PGC-1 protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

2011

Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) is a transcriptional coactivator that is a master regulator of oxidative stress and mitochondrial metabolism. Mitochondrial dysfunction and oxidative stress occur in Parkinson’s disease (PD), but little is known about the molecular mechanisms controlling these events. We report that transgenic mice overexpressing PGC-1 in dopaminergic neurons are resistant against cell degeneration induced by the neurotoxin MPTP. The increase in neuronal viability was accompanied by elevated levels of mitochondrial antioxidants SOD2 and Trx2 in the substantia nigra of transgenic mice. To modulate PGC-1, we employed the small molecula…

Between Scylla and Charibdis: eIF2α kinases as targets for cancer chemotherapy

2011

[EN] The eIF2 alpha kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell biology, ranging from regulation of cell cycle progression, maintenance of genome stability, control of apoptosis, and cell survival under nutrient stress and hypoxia. Accordingly, active eIF2 alpha kinases modulate the antineoplasic activity of several antitumour drugs, either by exacerbating their cytotoxic effect or by promoting chemoresistance. Understanding of eIF2 alpha kinases molecular roles may provide mechanistic insights into how tumour cells sense and adapt to …

STUDIO DELLA BIODISTRIBUZIONE DI SOSTANZE BIOLOGICAMENTE ATTIVE IN ORGANISMI ACQUATICI

2022

Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice

2020

Acute pancreatitis is an inflammatory process of the pancreatic tissue that often leads to distant organ dysfunction. Although liver injury is uncommon in acute pancreatitis, obesity is a risk factor for the development of hepatic complications. The aim of this work was to evaluate the role of PGC-1&alpha

Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

2020

Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…

Photodegradation of selected phthalates on mural painting surfaces under UV light irradiation

2014

Abstract The esters of phthalic acid are considered as hazardous pollutants due to their mutagenicity, carcinogenicity and are also classified as endocrine disruptor chemicals. Several compounds of this class of substances for decades, and probably even now, were used as softeners in water-based synthetic paintings. Surfaces and structures, such as house walls painted with phthalates based paintings, can be a concern to construction workers engaged in demolition, restore and paint removal activities if they are not protected from hazardous dust inhalation. In this paper we report the results of an investigation about phthalate ester degradation by direct UV irradiation at 254 nm. The result…

A new breath of life for anoxia.

2008

The middle of the Cretaceous (120–80 Ma) was one of the warmest periods of the past 300 m.y., with tropical sea-surface temperatures well over 30 °C ([Puceat et al., 2007][1]; [Forster et al., 2007a][2]) and atmospheric CO2 levels much higher than today. Therefore this period can give us crucial

Initial conditions in AA and pA collisions

2016

A full understanding of the spacetime evolution of the QCD matter created in a heavy ion collision requires understanding the properties of the initial stages. In the weak coupling picture these are dominated by classical gluon fields, whose properties can also be studied via the scattering of dilute probes off a high energy hadron or nucleus. A particular challenge is understanding small systems, where LHC data is also showing signs of collective behavior. We discuss some recent results of on the initial matter production and thermalization in heavy ion collisions, in particular in the gluon saturation framework.