Search results for "GCC"
showing 5 items of 5 documents
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
2021
ABSTRACT Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium nanodomains, that in turn trigger calcium-dependent signaling cascades and the release of chemical neurotransmitters. Based on their central importance as concierges of excitation-secretion coupling and therefore neuronal communication, VGCCs have been studied in multiple aspects of neuronal function and malfunction. However, studies on molecular interaction partners …
Frequency-Sliding Generalized Cross-Correlation: A Sub-Band Time Delay Estimation Approach
2020
The generalized cross correlation (GCC) is regarded as the most popular approach for estimating the time difference of arrival (TDOA) between the signals received at two sensors. Time delay estimates are obtained by maximizing the GCC output, where the direct-path delay is usually observed as a prominent peak. Moreover, GCCs play also an important role in steered response power (SRP) localization algorithms, where the SRP functional can be written as an accumulation of the GCCs computed from multiple sensor pairs. Unfortunately, the accuracy of TDOA estimates is affected by multiple factors, including noise, reverberation and signal bandwidth. In this paper, a sub-band approach for time del…
Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations
2014
Auditory hallucinations (AH) are the most frequent positive symptoms in patients with schizophrenia. Hallucinations have been related to emotional processing disturbances, altered functional connectivity and effective connectivity deficits. Previously, we observed that, compared to healthy controls, the limbic network responses of patients with auditory hallucinations differed when the subjects were listening to emotionally charged words. We aimed to compare the synchrony patterns and effective connectivity of task-related networks between schizophrenia patients with and without AH and healthy controls. Schizophrenia patients with AH (n = 27) and without AH (n = 14) were compared with healt…
Time Difference of Arrival Estimation from Frequency-Sliding Generalized Cross-Correlations Using Convolutional Neural Networks
2020
The interest in deep learning methods for solving traditional signal processing tasks has been steadily growing in the last years. Time delay estimation (TDE) in adverse scenarios is a challenging problem, where classical approaches based on generalized cross-correlations (GCCs) have been widely used for decades. Recently, the frequency-sliding GCC (FS-GCC) was proposed as a novel technique for TDE based on a sub-band analysis of the cross-power spectrum phase, providing a structured two-dimensional representation of the time delay information contained across different frequency bands. Inspired by deep-learning-based image denoising solutions, we propose in this paper the use of convolutio…
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development
2020
VGCCs are multisubunit complexes that play a crucial role in neuronal signaling. Auxiliary α2δ subunits of VGCCs modulate trafficking and biophysical properties of the pore-forming α1 subunit and trigger excitatory synaptogenesis. Alterations in the expression level of α2δ subunits were implicated in several syndromes and diseases, including chronic neuropathic pain, autism, and epilepsy. However, the contribution of distinct α2δ subunits to excitatory/inhibitory imbalance and aberrant network connectivity characteristic for these pathologic conditions remains unclear. Here, we show that α2δ1 overexpression enhances spontaneous neuronal network activity in developing and mature cultures of …