Search results for "GD"

Calcium-binding proteins in the dorsal ventricular ridge of the lizardPsammodromus algirus

1999

The aim of the present work was to study further the intrinsic organization of the dorsal ventricular ridge of lizards. For that purpose, the morphology and distribution of cells and fibers containing the calcium-binding proteins calbindin-D28k, parvalbumin, and calretinin were investigated by using immunohistochemical methods. Colocalization of calcium-binding proteins with the neurotransmitter gamma-aminobutyric acid (GABA) was also studied because they are shown to coexist in many areas of the telencephalon where they define distinct subpopulations of GABAergic local circuit neurons. Neurons containing calcium-binding proteins are limited to the anterior part of the dorsal ventricular ri…

Variable exposure and immunological response to Lyme disease Borrelia among North Atlantic seabird species.

2008

Colonial seabirds often breed in large aggregations. These individuals can be exposed to parasitism by the tick Ixodes uriae , but little is known about the circulation of pathogens carried by this ectoparasite, including Lyme disease Borrelia . Here we investigated the prevalence of antibodies (Ab) against Borrelia burgdorferi sensu lato in seabird species sampled at eight locations across the North Atlantic. Using enzyme-linked immunosorbent assay tests, we found that the prevalence of anti- Borrelia Ab in adult seabirds was 39.6% on average (over 444 individuals), but that it varied among colonies and species. Common guillemots showed higher seroprevalence (77.1%±5.9) than black-legged …

Docking and synthesis of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors: New scaffolds for DNA-interacting agents

2007

New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in silico for their ability to form stable complex with DNA fragment. In the docking studies two binding modes can be envisaged: groove mode and intercalating mode. In the case of the best ligands the docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies close to the minor groove. Synthetic approach to the PPD ring systems is discussed.

Combination of linear and nonlinear multivariate approaches effectively uncover responses of phytoplankton communities to environmental changes at re…

2022

The response of a community to environmental changes is either linear or non-linear, so that they can be investigated approximately by linear or nonlinear models. At community level, redundancy analysis (RDA) and canonical correspondence analysis (CCA), and Mantel test and Generalized Dissimilarity Modelling (GDM) are two pairs of fundamental multivariate approaches. Thus, it is necessary to determine how they are used for a given group of communities or a metacommunity. In the present study, we explored the applications of the two pairs of commonly used multivariate methods for the analysis of tropical phytoplankton communities. Phytoplankton were collected from 60 tropical reservoirs in s…

A brave new kingdom: images from the sea and in the coastal sanctuaries of Valencia (XIII–XV centuries)

2014

Tras la conquista de Jaime I, Valencia estaba llamada a convertirse en un nuevo reino cristiano por coherencia geopolítica y decisión real. Desde entonces el Reino de Valencia estaría orientado hacia la Cristiandad occidental y las rutas comerciales del Mediterráneo. Sin embargo, la falta de reliquias o imágenes planteaba un problema espinoso para los nuevos colonos cristianos y sus gobernantes. Las reliquias tuvieron que donarse más tarde, como el fragmento de la corona de espinas de Cristo ofrecida por el rey Luis IX de Francia a la catedral de Valencia o, al final de este período, el Santo Cáliz depositado como garantía de un préstamos por el rey Alfonso V el Magnánimo al tesoro de la mi…

Diurnal variation of corticotropin-releasing factor binding sites in the rat brain and pituitary.

1996

1. Corticotropin-releasing factor (CRF) is thought to be involved in the regulation of the diurnal activity of the hypothalamus-pituitary-adrenal (HPA) axis and to act as a neurotransmitter in the brain. To date it is unknown whether the binding sites of the central CRF system are subject to diurnal variations. 2. We measured the number of CRF binding sites over the course of a complete 24-hr light-dark cycle in the pituitary, amygdala, bed nucleus of the stria terminalis (BNST), cingulate cortex, visceral cortex, paraventricular nucleus of the hypothalamus, hippocampus, and locus ceruleus of rats by in vitro receptor autoradiography with iodinated ovine CRF. A 24-hr time course was also es…

Der Eigenthumserwerb am Wilde durch Occupation nach dem Privatrecht Liv-, Esth- und Kurlands, verglichen mit ausländischen Gesetzgebungen [... Eigent…

1904

Las asociaciones de inmigrantes como organizaciones no gubernamentales de desarrollo. Entre la agencia y la adaptación institucional

2020

De modo progresivo las asociaciones de inmigrantes en España se han convertido en un agente importante de la cooperación para el desarrollo. En este sentido, el entorno político, favorecido por la incorporación del codesarrollo en las políticas públicas a partir del año 2002, propició la creación de una estructura y una nueva ventana de oportunidad para las asociaciones de inmigrantes. Como resultado, en muchas de ellas se generaron procesos de adaptación o incluso hibridación organizativa hacia la reconversión como ONGD. Es por ello que, a raíz de los resultados de un estudio realizado sobre el estado de las entidades del campo de la cooperación para el desarrollo en España, debatimos y an…

2021

In humans and mammals, effort-based decision-making for monetary or food rewards paradigms contributes to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward-processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in adult C…

Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral …

2021

AbstractIn humans and mammals, effort-based decision-making for monetary or food rewards paradigms contribute to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in …