Search results for "GENETIC"

Genetic programming through bi-objective genetic algorithms with a study of a simulated moving bed process involving multiple objectives

2013

A new bi-objective genetic programming (BioGP) technique has been developed for meta-modeling and applied in a chromatographic separation process using a simulated moving bed (SMB) process. The BioGP technique initially minimizes training error through a single objective optimization procedure and then a trade-off between complexity and accuracy is worked out through a genetic algorithm based bi-objective optimization strategy. A benefit of the BioGP approach is that an expert user or a decision maker (DM) can flexibly select the mathematical operations involved to construct a meta-model of desired complexity or accuracy. It is also designed to combat bloat - a perennial problem in genetic …

Selection of the Proper Revenue and Pricing Model for SaaS

2014

Recent research on software revenue and pricing models has revealed important ways in which firms can benefit from software renting. However, it is still unclear how SaaS providers select a proper revenue and pricing model to make their services attractive for customers. Based on 32 interviews with software professionals from four case firms, this study reveals how different factors impacted on the selection of a revenue and pricing model. It can be concluded that customers’ needs were the main driving force to the selection of the most appropriate pricing and revenue model in the market. peerReviewed

Genetic relationship between clinical and environmental Vibrio cholerae isolates in Tanzania: A comparison using repetitive extragenic palindromic (R…

2015

The bacterium causing cholera, Vibrio cholerae, is a marine organism and coastal waters are important reservoirs of the organism. There are more than 200 serogroups of V. cholerae, of which serogroups O1 and O139 are known to be the causative agent of the cholera. The main virulent factor in V. cholerae is cholera toxin gene (ctx) that is found from the epidemic O1 and O139 strains, but may also be found in some strains other than O1 and O139 (non-O1 and non-O139). In this study, 48 V. cholerae strains isolated from three estuaries of Tanzania and 20 stool isolates were characterized in terms of their serogroups and possession of ctx gene and then compared using two PCR based fingerprinting…

The challenges of GxE research: A rejoinder

2017

Equal access to the top? Measuring selection into finnish academia

2019

In this article, we draw a parallel between equality of opportunity in educational transitions and equality of opportunity in academic careers. In both cases, many methodological problems can be ameliorated by the use of longitudinal rather than cross-sectional data. We illustrate this point by using Finnish full-population register data to follow the educational and academic careers of the 1964–1966 birth cohorts from birth to the present day. We show how the Finnish professoriate is highly selected both in terms of parental background and in terms of gender. Individuals of different backgrounds differ greatly in the likelihood of completing different educational and academic transitions, …

Prometeo genetista. Profitti delle tecniche e metafore della scienza

2016

Il saggio di Claude Calame affronta una tematica di grande rilievo scientifico, ossia il confronto tra il valore epistemologico e sociale dell'uso delle arti tecniche nell'antica Grecia e il valore epistemologico del linguaggio della scienza moderna in particolare applicato all'ambito della genetica e delle moderne biotecnologie e scienze di laboratorio. Lo spunto del confronto è offerto dall'analisi storico-culturale e antropologica del mito di Prometeo, come è stato diversamente declinato dai vari autori dell'antichità classica, a partire da Esiodo sino a Platone, passando per l'autore del dramma "Prometeo incatenato". In una prospettiva di indagine antropopoietica, le arti tecniche perme…

Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird

2018

Abstract Secondary sexual trait expression can be influenced by fixed individual factors (such as genetic quality) as well as by dynamic factors (such as age and environmentally induced gene expression) that may be associated with variation in condition or quality. In particular, melanin‐based traits are known to relate to condition and there is a well‐characterized genetic pathway underpinning their expression. However, the mechanisms linking variable trait expression to genetic quality remain unclear. One plausible mechanism is that genetic quality could influence trait expression via differential methylation and differential gene expression. We therefore conducted a pilot study examining…

Distinctive attributes for predicted secondary structures at terminal sequences of non-classically secreted proteins from proteobacteria

2008

Abstract C- and N-terminal sequences (64 amino acid residues each) of 89 non-classically secreted type I, type III and type IV proteins (Swiss-Prot/TrEMBL) from proteobacteria were transformed into predicted secondary structures. Multivariate analysis of variance (MANOVA) confirmed the significance of location (C- or N-termini) and secretion type as essential factors in respect of quantitative representations of structured (a-helices, b-strands) and unstructured (coils) elements. The profiles of secondary structures were transcripted using unequal property values for helices, strands and coils and corresponding numerical vectors (independent variables) were subjected to multiple discriminan…

Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining

2012

Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…

Religiosity and social support in Polish older adults: the mediating role of wisdom. Perspectives on Lars Tornstam’s theory of gerotranscendence

2021

Objectives: The purpose of this study was to examine whether wisdom is a mediator in the relation-ships between religious meaning system and social support among older adults. According to the theory of gerotranscendence, associations of religiousness and social support are complex and sug- gest the existence of wisdom in their internal structures. Method: The study included 466 persons aged 50–75. Three measures were used: Religious Meaning System Scale (RMSS), Three-Dimensional Wisdom Scale (3D-WS) and Berlin Social Support Scales (BSSS). Results: The analyses allowed for a partial verification of the hypothesis that wisdom is a mediator in the relationship between the religious meaning s…