Search results for "GENETICA"
showing 10 items of 906 documents
GM foods in Spanish newspapers.
2002
EU Experts’ Attitude Towards Use of GMO in Food and Feed and Other Industries
2014
Abstract This article examines European Union (EU) experts’ attitude towards use of genetically modified organisms (GMO) in food, feed and other industries with an eye to developing a general model of EU experts’ opinion formation in this area. The gene engineering has seen rapid advances in recent years with a host of new applications in medicine, agriculture, and related fields. Taking into account the history of consumption, social, economic, cultural and other aspects and the risk perception in general regarding these products the consumers’ willingness to buy genetically modified (GM) products varies from country to country as well as attitude of the experts involved in the decision ma…
Probiotics in transition: novel strategies
2015
Regulations regarding health claims made for probiotics demand their proven effectiveness and limit the array of microbial species regarded as safe for live consumption. Novel strategies such as moving to postbiotics and genetically modified probiotics may be necessary to increase the effectiveness of microbial products.
Raymond Queneau e la poetica dell’invenzione. Sulla genesi del romanzo
2017
La Critica genetica si impone negli anni Settanta come evoluzione dello Strutturalismo, sottoponendo ad analisi il processo creativo stesso attraverso lo studio dei manoscritti moderni. Come sottolinea Grésillon, si tratta di studiare «les manuscrits de travail des écrivains en tant que support matériel, espace d’inscription et lieu de mémoire des oeuvres in statu nascendi», nel tentativo di delineare la dinamica creativa di elaborazione dell’opera. La genetica sostituisce così all’osservazione del testo quella dell’avantesto, che permette sia di delineare le metamorfosi del testo sia di individuare quella che Grésillon definisce ‘poetica dell’invenzione’. Sono quindi i momenti/movimenti de…
ROLE OF THE ISWI CHROMATIN REMODELER FACTOR IN TISSUE REGENERATION
2014
Durante lo sviluppo degli organismi multicellulari, le modifiche epigenetiche della cromatina garantiscono l’attuazione dei programmi trascrizionali che guidano i processi di determinazione del destino cellulare. La presenza di modifiche epigenetiche della cromatina inoltre, assicura il mantenimento e la propagazione, nel corso delle divisioni mitotiche, di una memoria epigenetica cellulare. Tuttavia, sono note almeno due eccezioni a questo processo: la rigenerazione e la transdeterminazione Durante la rigenerazione tissutale, un fenomeno evolutivamente molto conservato, cellule già determinate affrontano cicli di proliferazione durante i quali possono riprogrammare la loro memoria epigenet…
Proteomic analysis highlights the role of detoxification pathways in increased tolerance to Huanglongbing disease.
2016
Background Huanglongbing (HLB) disease is still the greatest threat to citriculture worldwide. Although there is not any resistance source in the Citrus germplasm, a certain level of moderated tolerance is present. A large-scale analysis of proteomic responses of Citrus may help: 1) clarifying physiological and molecular effects of disease progression, 2) validating previous data at transcriptomic level, and 3) identifying biomarkers for development of early diagnostics, short-term therapeutics and long-term genetic resistance. Results In this work we have conducted a proteomic analysis of mature leaves of two Citrus genotypes with well-known differing tolerances to HLB: Navel orange (highl…
Analysis of Early Host Responses for Asymptomatic Disease Detection and Management of Specialty Crops
2010
The rapid and unabated spread of vector-borne diseases within US specialty crops threatens our agriculture, our economy, and the livelihood of growers and farm workers. Early detection of vector-borne pathogens is an essential step for the accurate surveillance and management of vector-borne diseases of specialty crops. Currently, we lack the tools that would detect the infectious agent at early (primary) stages of infection with a high degree of sensitivity and specificity. In this paper, we outline a strategy for developing an integrated suite of platform technologies to enable rapid, early disease detection and diagnosis of huanglongbing (HLB), the most destructive citrus disease. The re…
Antitumoral activity of curcumin: an adjuvant therapeutic strategy
2021
Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle…
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin.
2022
Background: Induced senescence could be exploited to selectively counteract the proliferation of cancer cells and target them for senolysis. We examined the cellular senescence induced by curcumin and whether it could be targeted by fisetin and quercetin, flavonoids with senolytic activity. Methods: Cell-cycle profiles, chromosome number and structure, and heterochromatin markers were evaluated via flow cytometry, metaphase spreads, and immunofluorescence, respectively. The activation of p21waf1/cip1 was assessed via RT-qPCR and immunoblotting. Senescent cells were detected via SA-β-Galactosidase staining. Results: We report that curcumin treatment specifically triggers senescence in cancer…
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway.
2010
Highly Expressed in Cancer protein 1 (Hec1) is a subunit of the Ndc80 complex, a constituent of the mitotic kinetochore. HEC1 has been shown to be overexpressed in many cancers, suggesting that HEC1 upregulation is involved in the generation and/or maintenance of the tumour phenotype. However, the regulation of Hec1 expression in normal and tumour cells and the molecular alterations promoting accumulation of this protein in cancer cells are still unknown. Here we show that elevated Hec1 protein levels are characteristic of transformed cell lines of different origins and that kinetochore recruitment of this protein is also increased in cancer cell lines in comparison with normal human cells.…