Search results for "GENI"
showing 10 items of 6843 documents
Immunogenicity and safety of a quadrivalent high-dose inactivated influenza vaccine compared with a standard-dose quadrivalent influenza vaccine in h…
2021
A quadrivalent high-dose inactivated influenza vaccine (IIV4-HD) is licensed for adults ≥65 y of age based on immunogenicity and efficacy studies. However, IIV4-HD has not been evaluated in adults aged 60–64 y. This study compared immunogenicity and safety of IIV4-HD with a standard-dose quadrivalent influenza vaccine (IIV4-SD) in adults aged ≥60 y. This Phase III, randomized, modified double-blind, active-controlled study enrolled 1,528 participants aged ≥60 y, randomized 1:1 to a single injection of IIV4-HD or IIV4-SD. Hemagglutination inhibition (HAI) geometric mean titers (GMTs) were measured at baseline and D 28 and seroconversion assessed. Safety was described for 180 d after vaccinat…
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrix™ hexa: T…
2014
Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11–12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been a…
Pienten lasten vanhempien koherenssin tunne ja liikuntakäyttäytyminen : Hyvän kasvun avaimet -tutkimuksen tuloksia
2017
Vanhemmat kokevat pikkulapsivaiheen usein haastavana elämänvaiheena. Yksilölliset tekijät vaikuttavat siihen, miten erilaisiin elämäntilanteisiin suhtaudutaan. Aaron Antonovskyn (1987) salutogeeniseen teoriaan keskeisesti kuuluva koherenssin tunne kertoo ihmisen kyvystä käsitellä stressiä ja hyödyntää käytettävissä olevia voimavaroja. Tämän pro gradu –tutkielman tarkoituksena oli selvittää, millainen koherenssin tunne suomalaisilla pienten lasten vanhemmilla on, minkälaista vanhempien liikuntakäyttäytyminen on ja onko koherenssin tunteella yhteyttä vanhempien liikuntakäyttäytymiseen. Tutkimusaineistona käytettiin Turun yliopiston toteuttaman Hyvän kasvun avaimet -seurantatutkimuksen aineist…
La trascrizione del certificato di nascita del figlio di coniugi “same sex”. Filiazione omogenitoriale, ordine pubblico internazionale e interesse de…
2015
Le odierne fugaci riflessioni prendono le mosse da un decreto con cui, in data 29 Ottobre 2014, la Corte d’Appello di Torino, ribaltando la decisione di primo grado, ha imposto all’ufficiale dello stato civile di trascrivere l’atto di nascita di un bambino risultante ab origine figlio di due madri, le quali, una spagnola e una Italiana, sposatesi in Spagna nel 2009, avevano procreato in Spagna tramite un procedimento di fecondazione eterologa. Il decreto in parola è di grande rilevanza in quanto senza precedenti, posto che sinora ciò che, talvolta, si era arrivato a riconoscere era la c.d. stepchild adoption, cioè l’adozione del figlio del partner (nei casi considerati, in una relazione omo…
Rat Cardiac progenitor cells and their application in cell therapy
2015
cells and the subsequent heart failure. When the pharmacological approach no longer complies with the disease evolution, organ transplantation appears to be the only treatment able to rescue the patient life. Cell therapy promises to be clinically efficient and would allow circumventing many limitations of organ transplantation, such as organ low availability, major surgical procedures, high costs and longterm immunosuppression [1]. We designed porous Poly-Lactic Acid (PLLA) and Fibroin scaffolds to deliver CPCs in the heart, we isolated and characterized CPCs for the expression of c-Kit, MDR-1 and Sca-1 by flow cytometry, we tested their degree of differentiation in vitro studying the expr…
Environmental factors influencing the distribution and prevalence of Schistosoma haematobium in school attenders of ILembe and uThungulu Health Distr…
2017
Schistosoma haematobium infection is reported to facilitate the development of urogenital diseases. Its symptoms include haematuria, dysuria and tiredness, and it may cause cognitive decline in children. The prevalence of S. haematobium infection needs to be known in endemic areas and a mass treatment programme against the disease implemented. The aim of this study was to investigate the prevalence and intensity of S. haematobium infection in ILembe and uThungulu health districts, using the major symptom, haematuria, as an indicator. A total of 6 265 urine samples, from 96 rural schools, was collected for analysis using dipsticks. The prevalence of haematuria in the ILembe health district w…
Fundamentos físicos de la informática (2009/10)
2009
Caracterización y germinación de semillas de Genista umbellata (L'Her.) Poir. (LEGUMINOSAE)
2016
Los territorios áridos y semiáridos del SE de la Península ibérica, nos ofrecen algunas especies con un gran atractivo de carácter ornamental. La especie analizada en esta ficha es un buen ejemplo de este hecho. Destaca por su profusa floración primaveral, con flores de un intenso color amarillo e inflorescencias en umbela. Este trabajo se ha cofinanciado por la Generalitat Valenciana (Consellería de Agricultura, Medio Ambiente, Cambio Climático y Desarrollo Rural, Servicio de Biodiversidad) y la Universitat de València.