Search results for "GERONTOLOGY"
showing 10 items of 2492 documents
What are the benefits of a minimally invasive approach in frail octogenarian patients undergoing aortic valve replacement?
2016
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RNA memory model: a RNA-mediated transcriptional activation mechanism involved in cell identity.
2010
Position-effect variegation (PEV) was discovered in Drosophila melanogaster in 1930 in a study of X-ray-induced chromosomal rearrangements. If a rearrangement places euchromatic genes adjacent to a region of centromeric heterochromatin, it gives a variegated phenotype that results from the random inactivation of genes by heterochromatin spreading from the breakpoint. After the establishment, the inactivation is henceforth clonally inherited. The vast majority of these modifiers were originally isolated in Drosophila as dominant mutations that suppressed or enhanced the variegation caused by a variegating white allele called white-mottled 4 (wm4). A large number of modifier genes alter PEV p…
Migration experience and mental health: A qualitative study in France and Brazil
2021
Background:The relationship between migration and mental health is complex and involves factors at different levels, as the individual history of the migrant, the collective history of their home country, the host society’s and their mutual past history. Even though the migratory scenario of France and Brazil has changed over the years, both countries currently host an important number of immigrants.Aim:The main objective of the present study was to describe and analyze the impacts of the migratory experience on mental health of migrants with different migration experiences and living in two countries: France and Brazil.Method:Semi-structured interviews were conducted with 13 participants, …
States of mourning: A quantitative analysis of national mournings across European countries
2018
Despite their growing incidence over the last decades, national days of mourning received curiously sparse attention throughout social sciences and death studies. This study investigates the 327 national mournings observed across European countries between 1989 and 2017 in terms of their national variance, temporal dynamics, typology of events that led to their declaration, and victimology. Drawing on a Durkheimian-inspired conceptualization of national mournings as political rites of solidarity and reconciliation, this article finds empirical support for the thesis that the frequency with which European countries declare national mourning is a negative function of a society's level of soci…
Prevention of Functional Decline by Reframing the Role of Nursing Homes?
2017
Institutionalization is generally a consequence of functional decline driven by physical limitations, cognitive impairments, and/or loss of social supports. At this stage, intervention to reverse functional losses is often too late. To be more effective, geriatric medicine must evolve to intervene at an earlier stage of the disability process. Could nursing homes (NHs) transform from settings in which many residents dwell to settings in which the NH residents and those living in neighboring communities benefit from staff expertise to enhance quality of life and maintain or slow functional decline? A task force of clinical researchers met in Toulouse on December 2, 2015, to address some of t…
Gerontology Research Center (GEREC), Universities of Jyväskylä and Tampere, Finland
2017
P3‐335: Upstream of N‐ras (UNR) is involved in translational control of ADAM10 protein expression
2008
Background: The amyloid beta peptide (A ) is derived by proteolytic processing of the amyloid precursor protein (APP) by the beta-secretase BACE1 and gamma-secretase. In contrast to this amyloidogenic processing, APP is predominantly cleaved by the alpha-secretase within the A domain and this precludes the formation of A . We and other research groups could show that BACE1 protein expression is regulated by the 5’untranslated region (UTR) of the BACE1 mRNA, however little is known about the regulation of alpha-secretase. Similar to the 5’UTR of BACE1, the 5’UTR of ADAM10 consists of 444 nucleotides with a GC-content of 70% and two upstream open reading frames. We hypothesize that ADAM10, th…
Hverdagslivet til foreldre som har barn med utviklingsmessige funksjonshemninger
2012
Published version of an article in the journal: Vård i Norden. Also available from the publisher at: http://www.artikel.nu/Bob/GetBob.aspx?bobID=3544 Purpose: The purpose of this study was to describe and illuminate the daily life of parents who have children with developmental disabilities. Background: Up to the 1980’s most children with disabilities were institutionalized. Today these children live with their families supported by public health care services and the family’s social network. Parents experience extreme strain due to unpredictability, sleep deprivation, multiple hospitalizations and demanding caregiving procedures. Method: Semi structured interviews of four couples of parent…
How Can We Integrate Life Course Vaccination into the New WHO Definition of “Healthy Ageing”?
2019
The first global report on health and ageing published by the World Health Organization (WHO) in 2015 introduced a new and innovative concept, namely, the idea that healthy ageing encompasses more than just the absence of disease. The report considered healthy ageing to be a more holistic process of developing and maintaining the functional ability that enables well-being in older age. There are two major components to this concept, namely, personal and environmental determinants of ageing. Personal determinants of ageing correspond to our intrinsic capacity, including our genetic inheritance, personal characteristics, health-related behaviours, and risk factors. Living our daily lives in g…
Vaccination in old age: Challenges and promises
2021
Abstract Vaccination is one of the most effective medical interventions ever introduced, preventing millions of cases of infections worldwide every year. However, vaccines are commonly believed to be less effective in providing protection in older adults, due to the perceived decline seen in immunity in this population (“immunosenescence”). Accordingly, this chapter considers how to identify hallmarks of immunosenescence and approach their resolution strategically. It was reviewed potential options for therapeutic intervention to restore appropriate responses to vaccines in older adults.