Search results for "GK"

Zur Rolle von Sprachen an finnischen Hochschulen : Eine Umfrage unter dem Hochschulpersonal

2010

Suomessa on perinteisesti ymmärretty vieraiden kielten opiskelun tärkeys. Suomalaisissa peruskouluissa on opiskeltu vierasta kieltä pakollisena oppiaineena jo 1970-luvulta saakka. Viime vuosikymmeninä vieraiden kielten opiskelun into on kuitenkin laantunut, ja erityisesti valinnaisten kielten opiskelu on selkeästi vähentynyt. Samalla kuitenkin suomalainen työelämä kansainvälistyy, ja yhä useammilla aloilla vieraan kielen taidot ovat tarpeen. Tämän tutkimuksen tarkoituksena on selvittää monikielisyyden, eli useiden vieraiden kielten osaamisen ja käytön, merkitystä suomalaisissa korkeakouluissa sekä erityisesti saksan ja ruotsin kielen roolia työkielinä. Kyselytutkimuksen avulla selvitettiin …

Die Förderung der Mehrsprachigkeit und der Transkulturalität in der gymnasialen Oberstufe über ein internationales und fremdsprachiges Projekt : Fal…

2010

Tässä laadullisessa tapaustutkimuksessa tutkittiin 2008 kevään aikana suomalaisen Jyväskylän Normaalikoulun lukion ja saksalaisen Görres-Gymnasiumin (Koblenz) toteuttamaa kansainvälistä yhteistyöprojektia. Tavoitteena oli selvittää, kuinka osallistujien transkulturaalinen identiteetti kehittyy sekä toteutuuko monikielisyys tässä kansainvälisessä projektissa. Lisäksi haluttiin selvittää opettajien ja oppilaiden motivaatioita projektiin osallistumiseen sekä kieltenkäyttöä eri tilanteissa. Tutkimus toteutettiin vuonna 2007 projektiin osallistuneiden suomalaisten oppilaiden sekä vuonna 2008 mukana olevien suomalaisten ja saksalaisten opettajien ryhmähaastattelujen ja oppilaiden kyselylomakkeide…

Brief an Karl Axel Christer Freiherr von Bruiningk

1839

Ms. 930a, Nr. 6b, Bl. 19r-19v Merkel, Garlieb H. Brief an Karl Axel Christer Freiherr von Bruiningk, [Depkinshof ?], [bez datuma; ohne Datum, pēc / nach 1839] Autora rokraksts / Autograph, vācu val. / Deutsch, [2] lpp. / S. Attēlu numuri / Bildnummern: 930a-006b-1 – 930a-006b-2 In dem undatierten Entwurf einer Antwort auf einen Brief Bruiningks [womit der unter Ms. 930a, Nr. 6a gemeint wird, bleibt noch unklar] lobt Merkel dessen Einsatz für die Bauernbefreiung. Das Problem des fehlenden Grundbesitzes für die freigelassenen Bauern sei ein Grund für die wirtschaftliche Rückständigkeit der „vaterländische[n] Provinzen“. Selbst in Posen (Preußen) und Galizien (Österreich) hätte die wirtschaftl…

Single-tube nested quantitative PCR: a rational and sensitive technique for detection of retroviral DNA. Application to RERV-H/HRV-5 and confirmation…

2003

It was reported earlier that a few patients suffering from non-Hodgkin's lymphoma had low amounts of DNA from the so-called fifth human exogenous retrovirus, HRV-5. A sensitive and rational method for large-scale screening for HRV-5 DNA was therefore developed. It is a single-tube nested quantitative PCR (stnQPCR), which uses two functionally isolated primer pairs and one probe target distinct from related endogenous retroviral sequences, yet encompassing known HRV-5 variation, allowing optimal use of sequence conservation. DNA from lymphoma, myeloma, and follicular dendritic cell lines was tested for HRV-5 positivity, as was DNA from whole blood of blood donors, non-Hodgkin's lymphoma and …

Mixed-model of ANOVA for measurement reproducibility in proteomics

2009

This work is a statistical analysis of reproducibility of a MALDI-TOF mass spectrometry experiment. Its aim is to evaluate measurement variability and compare peak intensities from two types of MALDI-TOF platforms. We compared and commented on the abilities of Principal Component Analysis and mixed-model analysis of variance to evaluate the biological variability and the technical variability of peak intensities in different patients. The properties and hypotheses of both methods are summarized and applied to spectra from plasma of patients with Hodgkin lymphoma. Principal Component Analysis checks rapidly the balance between the two variabilities; however, a mixed-model analysis of varianc…

Zur Arbeitsmotivation und Arbeitszufriedenheit : Deutschlehrer der Klassen 7-9 in der finnischen Grundschule als Forschungsgegenstand

2004

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

2013

International audience; Bleomycin (BLM) is an anticancer drug currently used for the treatment of testis cancer and Hodgkin lymphoma. This drug triggers cancer cell death via its capacity to generate radical oxygen species (ROS). However, the putative contribution of anticancer immune responses to the efficacy of BLM has not been evaluated. We make here the observation that BLM induces immunogenic cell death. In particular, BLM is able to induce ROS-mediated reticulum stress and autophagy, which result in the surface exposure of chaperones, including calreticulin and ERp57, and liberation of HMBG1 and ATP. BLM induces anti-tumor immunity which relies on calreticulin, CD8(+) T cells and inte…

Transplanting the genetic susceptibility to Crohn’s disease

2003

Susceptibility to Crohn’s disease may be transferred via haematopoietic stem cells, highlighting the pivotal role of genetic factors in the pathogenesis of Crohn’s disease Crohn’s disease (CD) is one of the two most common forms of inflammatory bowel disease (IBD). The prevalence of CD has increased in Western countries over the past decades and mainly young patients are affected, with a peak incidence between 15 and 35 years.1 The aetiology of IBD is still unclear and should be considered as multifactorial according to recent studies.2 Genetic factors seem to play a pathogenic role as well as environmental, infectious, and immunological factors. All of these different aetiological aspects …

Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: resul…

2013

Purpose Inotuzumab ozogamicin (INO) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic agent. We performed a phase I/II study to determine the maximum-tolerated dose (MTD), safety, efficacy, and pharmacokinetics of INO plus rituximab (R-INO) for treatment of relapsed/refractory CD20+/CD22+ B-cell non-Hodgkin lymphoma (NHL). Patients and Methods A dose-escalation phase to determine the MTD of R-INO was followed by an expanded cohort to further evaluate the efficacy and safety at the MTD. Patients with relapsed follicular lymphoma (FL), relapsed diffuse large B-cell lymphoma (DLBCL), or refractory aggressive NH…

Unbiased estimates of long-term net survival of hematological malignancy patients detailed by major subtypes in France.

2012

Long-term population-based survival data detailed by cancer subtype are important to measure the overall outcomes of malignancy managements. We provide net survival estimates at 1, 3, 5 and 10-year postdiagnosis on 37,549 hematological malignancy (HM) patients whose ages were >15 years, diagnosed between 1989 and 2004 and actively followed until 2008 by French population-based cancer registries. These are, to our knowledge, the first unbiased estimates of 10-year net survival in HMs detailed by subtypes. HMs were classified according to the International Classification of Diseases-Oncology 3. Net survival was estimated with the unbiased Pohar-Perme method. The results are reported by sex an…