Search results for "GLUTATHIONE S-TRANSFERASE"

showing 2 items of 22 documents

Enzymes as Regulators of Toxic Reactions by Electrophilic Metabolites

1979

Conversion of many compounds which are not electrophilically reactive as such to metabolites responsible for cytotoxic, mutagenic and/or carcinogenic effects is catalyzed by mammalian enzymes. Many reactive agents, whether metabolites or parent compounds, are also subject to inactivation by mammalian enzymes.

chemistry.chemical_classificationchemistry.chemical_compoundEnzymeGlutathione S-transferaseEpoxide HydratasechemistryBiochemistrybiologyBenzo(a)pyreneElectrophilebiology.proteinCarcinogen
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Glutathione S Transferase Polymorphisms Influence on Iron Overload in β-Thalassemia Patients

2013

In patients with β-thalassemia iron overload that leads to damage to vital organs is observed. Glutathione S transferase (GST) enzymes have an antioxidant role in detoxification processes of toxic substances. This role is determined genetically. In this study, we correlated GSTT1 and GSTM1 genotypes with iron overload measured with direct and indirect non-invasive methods; in particular, we used serum ferritin and signal intensity of the magnetic resonance image (MRI) in 42 patients with β-thalassemia, which were regularly subjected to chelation and transfusion therapy. Multiplex polymerase chain reaction was used to determine the genotype. The loss of both alleles leads to a decreased valu…

medicine.medical_specialtyThalassemiaglutathione S transferases; β-thalassemia; iron overloadBiologymedicine.diseaseglutathione S transferases β-thalassemia iron overload.EndocrinologyGlutathione S-transferaseBiochemistryInternal medicinemedicinebiology.proteinDiseases of the blood and blood-forming organsRC633-647.5Thalassemia Reports
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