Search results for "GOME"

Pacienta sagatavošana un aprūpe veloergometrijas izmeklējumam

2020

Bakalaura darba tēma “Pacienta sagatavošana un aprūpe veloergometrijas izmeklējumam” tika izvēlēta, jo pacientu iepriekšēja sagatavošana, izglītošana un aprūpe ietekmē izmeklējuma rezultātu kvalitāti. Kā piemēram nepareiza medikamentu lietošana pirms slodzes testa var uzlabot testa iznākumu, kā arī liela nozīme ir apģērbam, kurā tiek veikts veloergometrijas izmeklējums. Darba mērķis: noskaidrot, kā tiek sagatavots un aprūpēts pacients veloergometrijas izmeklējumam. Darbā tika izvirzīts pētījuma jautājums: kā tiek sagatavots un aprūpēts pacients veloergometrijas izmeklējumam? Bakalaura darbā tika izmantota kvalitatīvā pētījuma metode. Pētījuma instruments bija strukturēta intervija. Pētījuma…

Legiones y Falanges: Estrategias argumentativs para 《una España Nueva, Libre y Grande》

2015

L’attualità sociale e politica, ma anche la scelta dei contenuti culturali, sotto l’autorevolezza della firma del soggetto argomentante, assumono i toni del discorso ideologico e performativo, plasmando coscienze e muovendo all’azione. In questo contesto, la persuasione può assumere i toni della manipolazione, della messa in atto di una forma di influenza illegittima. Così, temi come la guerra, la rivoluzione, l’impero, il declino e la resurrezione della Spagna, la cristiandad e la cruzada, la sangre hispana o il pericolo “rosso”, definiscono un discorso ideologico, dai toni populisti e fascisti (ma anche religiosi), che mira a costruire una ‘España Nueva, Libre y Grande’ per la quale il re…

Argomento storico e diritto civile. Con uno sguardo alla forma e ai rimedi

2022

Il contributo aspira a delineare alcuni indirizzi di metodo minimi sull’uso dell’argomento storico nel diritto civile, portando due esempî tra loro eterogenei: il formalismo testamentario e l’equilibrio contrattuale.

Solid state conformational behavior and interactions of a series of aromatic oligoamide foldamers

2016

The topic of this thesis is aromatic oligoamide foldamers. The literary review of the thesis discusses the general features of foldamers and their design and then focuses on the specific examples of aromatic oligoamide foldamers. The experimental part of the thesis discusses the design and preparation of a family of aromatic oligoamide foldamers that can adopt a helical conformation. The folding is directed by intramolecular hydrogen bonding and stabilized by intramolecular aromatic interactions. The focus of the thesis is the analysis of the solid state conformations of ten foldamer analogues. The analysis is based on forty different crystal structures which are determined using single cry…

Brevi considerazioni sugli orizzonti comparatistici della responsabilità civile alla luce delle connessioni tra dottrina e giurisprudenza

2016

Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation

2019

Alzheimer's disease (AD) is the leading cause of dementia worldwide. While the etiology of AD remains uncertain, neurotoxic effects of amyloid beta oligomers (Aβo) on synaptic function, a well-established early event in AD, is an attractive area for the development of novel strategies to modify or cease the disease's progression. In this work, we tested the protective action of the mitochondrial chaperone Hsp60 against Aβo neurotoxicity, by determining the direct effect of Hsp60 in changing Aβo toxic conformations and thus reducing their dysfunctional synaptic binding and consequent suppression of long-term potentiation. Our data suggest that Hsp60 has a direct impact on Aβo, resulting in a…

Water Adsorption Properties of Free and Dehydrated β-Cyclodextrin Studied by near Infrared Spectroscopy and Gravimetry

2016

β-cyclodextrin, like other carbohydrates has a tendency to adsorb water molecules and the properties are attributed to the hydroxyl groups in the molecules. β-cyclodextrin, the cyclic oligomer of glucose has a hydrophobic interior and hydrophilic exterior. The cyclic structure favours the formation of hydrogen bonds between the OH groups on the adjacent glucose units and affects the formation of hydrogen bonds with water molecules. The hydoxyl groups engaged in hydrogen bondings can be eliminated at high temperatures and the adsorption properties of the dehydrated β-cyclodextrin will depend on the new functional groups formed. The aim of the report is to discuss the issue of the water adsor…

Introduction: Protein Oligomerization and the Formation of Macromolecular Assemblies

2019

The ability of biomolecules to link together to form higher order assemblies underlies much of cellular structure and function. Here we emphasise protein oligomerisation and discuss some of the principles of molecular interaction, from early considerations through to the present day. A few protein examples are presented, selected from our research interests, to highlight assembly features, ranging from the hemoglobins, the hemocyanins to the peroxiredoxins, collagen, the encapsulins and ferritins.

2021

Amino acids with small side chains and motifs of small residues in a distance of four are rather abundant in human single-span transmembrane helices. While interaction of such helices appears to be common, the role of the small residues in mediating and/or stabilizing transmembrane helix oligomers remains mostly elusive. Yet, the mere existence of (small)xxx(small) motifs in transmembrane helices is frequently used to model dimeric TM helix structures. The single transmembrane helix of the human carbonic anhydrases XII contains a large number of amino acids with small side chains, and critical involvement of these small amino acids in dimerization of the transmembrane domain has been sugges…

1991

Tracer diffusion coefficients D* of both components were measured in mixtures of polystyrene (PS) and polymethylstyrene (PMS), a random copolymer from 60 wt.-% of m-methylstyrene and 40 wt.-% of p-methylstyrene. The results are interpreted in terms of the free-volume theory which yields master curves even for “asymmetric” mixtures of oligomer and polymer chains, if D* is drawn versus the distance from the glass transition temperature, T–Tg. Whereas D* was measured by the forced Rayleigh scattering technique, we also studied photon correlation spectroscopy in these mixtures and observed “slow modes” with decay constants that correspond to diffusion coefficients 2–3 decades smaller than the i…