Search results for "GPR"
showing 10 items of 1092 documents
Johtaminen ja tarinankerronta organisaatioissa digitaalisessa vallankumouksessa
2017
Digitalization is the most recent and still ongoing industrial revolution, which challenges the traditional leadership theories while also organizational storytelling needs to be revised. This article summarizes the focal phases of leadership theory development while the focus is particularly on organizational storytelling. The purpose is to reflect leadership (theory and practice) in terms of digitalization by discussing such questions as how digitalization has been taken into cognizance this far and how digitalization will transform organizational storytelling and leadership in the future? Three illustrative empirical cases have been applied with a view to reveal insights on the nature an…
Changing Managers for a Changing Economy – The Need for Creativity and Leadership
2013
Abstract The present paper aims to identify new approaches of management by re-considering business comportment and attitudes. The research looked into specialized literature on new development of business in the post-crisis era and, on another hand, on leadership and organizational culture, in order to establish a possible profile of the most efficient management and organizational culture adapted to the new challenges of business environment, intending to demonstrate that managers need to develop leadership traits and re-shape organizational culture for a better business performance.
Manager versus Leader. Why Are Both Roles Valuable?
2018
The confluence between a good manager and a good leader stands at the intersection of skills, strategic thinking and ethical integrity specific to the manager and the emotional intelligence, power of persuasion, empathy, passion and open communication specific to the leader. In this context, the present paper’s objective is to highlight the interconnection between the management / managers and leadership/leaders.
Identification of lipid accumulation in lacrimal gland from NOD mice
2008
International audience; Purpose: : The NOD mouse is an established animal model of the human disease, Sjögren’s syndrome. The lacrimal gland of male NOD mouse becomes significantly infiltrated with inflammatory cells by 12 weeks of age. Dacryadenitis is associated with massive lipid deposition in the lacrimal acinar cells, a process which starts by 6 weeks of age and is accompanied by onset of inflammatory infiltrates. The aim of this study was to identify the lipids that accumulate in lacrimal glands from NOD mice. Methods: : Lacrimal glands were excised from 12-week-old male NOD (n = 8) and BALB/c mice (n = 10). Lipids were extracted and lipid class distribution examined. Then the lipid c…
Toxicity of Branched-Chain Fatty Acids in Conjunctival Cell Line
2007
International audience; Purpose:: Tear film lipid composition is modified in patients suffering from chronic blepharitis. We previously found that branched chain fatty acids (BCFA) were significantly increased in tears of these patients, suggesting that BCFA may be involved in the disease. The toxicity of different BCFA as potent inducers of apoptosis has already been established in various cell lines but not in the conjunctiva. The aim of this work was to assess the toxic effects of BCFA in cultures of Chang conjunctival cells. Methods:: Chang’s human conjunctival cells were cultured during 4 or 24h with various concentrations of IsoC16 and IsoC20 as BCFA (from 50 to 200µM), by comparison …
Anti-inflammatory effects of GLA and EPA on a scopolamine-induced dry eye rat model
2007
International audience; Purpose:: The aim of this study was to evaluate the potential anti-inflammatory effects of dietary γ-linolenic acid (GLA) and eicosapentaenoic acid (EPA) in a scopolamine-induced dry eye rat model. Methods:: Female Lewis rats were fed with 5%-lipid diets containing 10% of either GLA or EPA. After two months of feeding, we induced dry eye syndrome using scopolamine continuously delivered via osmotic pumps for 2, 10 and 28 days. At the end of the treatment period, we performed fluorescein staining on the cornea. We sacrificed the animals and excised the ocular tissues and the exorbital lacrimal glands. We immunostained MHCII and mucin MUC5AC on ocular sphere cryosectio…
RPE/Choroid and Neuroretina Differences in Lipid Profile in Humans, and Possible Correlations to Dietary Lipid Intake
2008
International audience; Purpose: : To provide data on the differences in the lipid profile of the neural retina and RPE/choroid in healthy human eyes, and to establish plausible relationships with dietary fat intake, by comparing the lipid profile of the extra orbital fat. Methods: : Human eyes were collected from 28 human donors. The neural retina was dissected from the RPE/choroid. In 6 donors, the lacrimal gland and a piece of the extra orbital fat were collected. The lipid profile of the human samples was analyzed into classes. Phospholipids and cholesteryl esters were purified from RPE/choroid. The fatty acid composition of the retina, lipid fractions of RPE/choroid, and lacrimal gland…
The Exorbital Lacrimal Gland Is 100 Times More Susceptible Than the Retina to Dietary Supplies in Long Chain Omega-6 and Omega 3 Polyunsaturated Fatt…
2007
International audience; Purpose:: The purpose of this study was to compare the susceptibility of the retina and the exorbital lacrimal gland to dietary supplies in long chain omega-3 (ω3) and omega-6 (ω6) polyunsaturated fatty acids (LC-PUFAs). Methods:: Male Wistar rats were fed for 3 months with a 5% lipid-diet containing either: 1) 10% of EicosaPentaenoic Acid (EPA, ω3) and 7% of DocosaHexaenoic Acid (DHA, ω3), 2) 10% of γ-Linolenic Acid (GLA, ω6), 3) 10% of EPA, 7% of DHA and 10% of GLA or 4) a balanced diet deprived from EPA, DHA and GLA. After three months of feeding, lipids were extracted from the retina and the exorbital lacrimal gland and fatty acid composition was determined by ga…
Darwin and Ethics : Using Natural Selection to Understand Ethical Business and Organizational Behavior
2000
The origins of ethics and morality have been considered for many, many years. From ancient Greek metaphysicians to the great theologians of the Middle Ages to modern philosophers, different systematic frameworks have been developed to understand how and why ethics are formed. These frameworks provide people and organizations with guidance about how to act toward other humans and institutions in their environment. Steiner and Steiner (1991) discuss six different primary sources for understanding the development of ethics: religious, philosophical, cultural, legal, codes of conduct, and genetics (see Table). Of these six systems, the genetic framework is clearly the least developed, least exp…
Professional learning and agency in an identity coaching programme
2016
This article addresses the professional learning that occurred in an identity coaching programme. The arts-based programme aimed to enhance the participants’ professional learning, notably through helping them to process their professional identities. Professional learning was seen as resourced by the participants’ professional agency, and by the promotion of such agency. Through interviews, we investigated what the participants perceived they had learnt during the programme, and the potential differences in learning outcomes between professional groups from university and hospital contexts. The findings showed that the programme was perceived as a rich learning arena in the domains of the …