Search results for "GPR"
showing 10 items of 1092 documents
CMYC PROMOTER BINDINGPROTEIN 1 (MBP1) AS A NOVEL MARKER TO IDENTIFY NEW SUBTYPES OF ERBB2 NEGATIVE BREAST TUMORS
2011
Diagnostic Multidisciplinary Investigations for Cultural Heritage at Etna Volcano: A Case Study from the 1669 Eruption in the Mother Church at the Ol…
2022
Misterbianco is located on the southern flank of Mt. Etna (Unesco site), in eastern Sicily (Italy). This site, also known as Monasterium Album, has a long and tormented history linked with volcanic activity of Mt. Etna and regional seismicity. This site received much attention in the 2000s when excavation works brought to light a 14th century church remains below the thick layer of the 1669 lava. This study documents the first diagnostic multidisciplinary survey performed at this site 350 years after the eruption: the investigations were performed by using techniques such as ground-penetrating radar, infrared thermography, a terrestrial laser scanner and a drone survey to analyze the site’s…
New considerations for modelling a MED-TVC plant under dynamic conditions
2019
Abstract The multiple-effect distillation (MED) technology is nowadays the most promising desalination process to be coupled with variable heat sources, thus leading to a more sustainable way to produce water. In order to prove the potential of this, it is of major interest to develop powerful modelling tools to predict the performance of this coupling. Only a few models have been presented so far. They show promising results but were based on some simplifying assumptions and non-physical constraints that could limit the analysis of the dynamic behaviour of a MED plant. This paper presents new considerations for the dynamic modelling of a MED plant associated with a thermal vapour compressi…
Separation of Concerns and Role Implementation in the PASSI Design Process
2007
The use of design patterns proved successful in lowering the development time and number of errors when producing software with the object-oriented paradigm. In previous works we engaged the production of a tool for the reuse of patterns for multi-agent systems. Now we are fronting a new problem: automatic code generation for agents, designed with a specific methodology, with the support of design patterns and using an aspect oriented approach. In this work we present our preliminary experiences in the identification, description, production and use of aspects for multi agent systems and a tool for code production.
Targeted delivery of siRNAs against hepatocellular carcinoma-related genes by a galactosylated polyaspartamide copolymer
2021
Given the lack of effective treatments for Hepatocellular carcinoma (HCC), the development of novel therapeutic approaches is very urgent. Here, siRNAs were delivered to HCC cells by a synthetic polymer containing α,β-poly-(N-2-hydroxyethyl)-D,L-aspartamide-(PHEA) derivatized with diethylene triamine (DETA) and bearing in the side chain galactose (GAL) linked via a polyethylene glycol (PEG) to obtain (PHEA-DETA-PEG-GAL, PDPG). The GAL residue allows the targeting to the asialo-glycoprotein receptor (ASGPR), overexpressed in HCC cells compared to normal hepatocytes. Uptake studies performed using a model siRNA or a siRNA targeted against the enhanced green fluorescence protein, demonstrated …
The Problem of the First Belief: Group Agents and Responsibility
2020
Abstract Attributing moral responsibility to an agent requires that the agent is a capable member of a moral community. Capable members of a moral community are often thought of as moral reasoners (or moral persons) and, thus, to attribute moral responsibility to collective agents would require showing that they are capable of moral reasoning. It is argued here that those theories that understand collective reasoning and collective moral agency in terms of collective decision-making and commitment – as is arguably the case with Christian List and Philip Pettit’s theory of group agency – face the so-called “problem of the first belief” that threatens to make moral reasoning impossible for gr…
Factors affecting social integration and transversal skills of college students: a preliminary study
2015
International audience; This research, as a part of a PhD thesis in educational sciences relates to the social network and the transversal skills developed by the Bachelor's degree students ("Licence") in a French college. Overall, this work aims at identifying and estimating origins and effects of student social integration and transversal skills within the college careers. Four areas of student social integration and ten skills stemming from a reference table are measured by an original questionnaire. In this paper, the first preliminary results of this work are presented and reveal the influence of various personal and contextual factors on the integration and skills scores stated by stu…
Experiences from Software Maintenance Seminars: Organizing Three Seminars with 127 Groups
2009
Software maintenance and evolution (SME) is an important but problematic topic-area for university-level computer science education. Seminars can be used to provide versatile and up-to-date knowledge for students regarding scientifically relevant issues. We have organized three systematic university-level seminars on SME with a total of 127 seminar groups. Each group has been assigned a task of analyzing one scientific SME-article. The main results include the general confirmed feasibility of the selected seminar-based approach. The paper describes the background of the seminars, their contents, and experiences concerning organization and feasibility of the seminars. The results support org…
Opportunities and challenges of digitized discretionary practices: a public service worker perspective
2018
Abstract Public service workers exercise discretionary power during policy implementation. Due to an immense diffusion of information and communications technology (ICT) in public service provision, they are increasingly exposed to reforms aiming at more efficient and fair decision-making. Whereas extant literature has found that ICT can both enable and constrain public service workers' ability to exercise discretion, we know less about underlying explanations for these inconclusive findings. This paper addresses this research gap by exploring how and why public service workers react to digitized discretionary practices. We draw upon institutional logics to show the underlying consideration…
Virtual Exchange Project Reflective Essay
2021
Essay instructions: students are asked to write a personal reflective essay about the virtual exchange project (around 400 words), following the guidelines provided. Essay instructions: students are asked to write a personal reflective essay about the virtual exchange project (around 400 words), following the guidelines provided.