Search results for "GPT"
showing 10 items of 14 documents
Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins.
2017
Abstract Context Angiopoietin-like 3 (ANGPTL3) deficiency in plasma due to loss-of-function gene mutations results in familial combined hypobetalipoproteinemia type 2 (FHBL2) in homozygotes. However, the lipid phenotype in heterozygotes is much milder and does not appear to relate directly to ANGPTL3 levels. Furthermore, the low-density lipoprotein (LDL) phenotype in carriers of ANGPTL3 mutations is unexplained. Objective To determine whether reduction below a critical threshold in plasma ANGPTL3 levels is a determinant of lipoprotein metabolism in FHBL2, and to determine whether proprotein convertase subtilisin kexin type 9 (PCSK9) is involved in determining low LDL levels in this conditio…
Clinical and biochemical characteristics of individuals with low cholesterol syndromes: A comparison between familial hypobetalipoproteinemia and fam…
2017
Background The most frequent monogenic causes of low plasma cholesterol are familial hypobetalipoproteinemia (FHBL1) because of truncating mutations in apolipoprotein B coding gene (APOB) and familial combined hypolipidemia (FHBL2) due to loss-of-function mutations in ANGPTL3 gene. Objective A direct comparison of lipid phenotypes of these 2 conditions has never been carried out. In addition, although an increased prevalence of liver steatosis in FHBL1 has been consistently reported, the hepatic consequences of FHBL2 are not well established. Methods We investigated 350 subjects, 67 heterozygous carriers of APOB mutations, 63 carriers of the p.S17* mutation in ANGPTL3 (57 heterozygotes and …
Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway
2017
The angiopoietin-like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as angiopoietins. At first, ANGPTL4 has been identified as an adipokine exclusively involved in lipid metabolism, because of its prevalent expression in liver and adipose tissue. This protein regulates lipid metabolism by inhibiting lipoprotein lipase (LPL) activity and stimulating lipolysis of white adipose tissue (WAT), resulting in increased levels of plasma triglycerides (TG) and fatty acids. Subsequently, ANGPTL4 has been shown to be involved in several nonmetabolic and metabolic conditions, both physiological and pathological, including …
CLINICAL CHARACTERISTICS AND PLASMA LIPIDS IN SUBJECTS WITH FAMILIAL COMBINED HYPOLIPIDEMIA: A POOLED ANALYSIS
2013
Background. Angiopoietin-like 3 (ANGPTL3) regulates lipoprotein metabolism by modulating extracellular lipases. Loss-of function mutations in ANGPTL3 gene cause familial combined hypolipidemia (FHBL2). The mode of inheritance and hepatic and vascular consequences of FHBL2 have not been fully elucidated. To get further insights on these aspects, we re-evaluated the clinical and the biochemical characteristics of all reported cases of FHBL2. Methods and Results. One hundred fteen FHBL2 individuals carrying 13 different mutations in the ANGPTL3 gene (14 homozygotes, 8 compound heterozygotes and 93 heterozygotes) and 402 controls were considered. Carriers of 2 mutant alleles had undetectable pl…
Conversazioni umane e artificiali
2023
C’è una caratteristica centrale che distingue ChatGPT e simili da un interlocutore umano: pur sapendo rispondere in modo coerente e creativo a richieste anche complesse, sono del tutto incapaci di proporre contenuti conversazionali non puramente reattivi, manca, all’AI, la parte “affiliativa” della conversazione
Datora ģenerēta proza un dzeja
2020
Datora ģenerētas prozas un dzejas veidošanas metodes laika gaitā ir mainījušās. Datora ģenerētu prozu un dzeju arvien grūtāk ir atpazīt no cilvēka radītas daiļliteratūras. Tiek radītas jaunas metodes, kas mēģina atpazīt datora radītos tekstus. Darbā tiks iepazīta datora ģenerētas prozas un dzejas vēsture un izpētītas problēmas, ar ko vēstures laikā bija nepieciešams tikt galā, veidojot prozas un dzejas darbus. Darba mērķis ir izpētīt dažādas datora ģenerēta teksta veidošanas metodes un salīdzināt tās. Ir izveidoti vairāki rīki, kuros ar dažādu metožu palīdzību tiks ģenerēta proza un dzeja. Darbā tiks salīdzināti dažādi pieejamie prozas un dzejas veidošanas rīki, īpaši tiks pētīts GPT – 2 va…
Datora ģenerēta dzeja
2022
Pēdējos gados ir bijuši vairāki mēģinājumi ar datora palīdzību automātiski ģenerēt arī ko radošu – vizuālās mākslas radīšana, radoša teksta ģenerēšana vai pat mūzikas skaņdarbu komponēšana – šīs ir tikai dažas no jomām, ar kurām darbojas mākslīgais intelekts. Dabiskās valodas ģenerēšana ir visai daudzsološa mākslīgā intelekta un datorlingvistikas apakšnozare, kuras galvenais mērķis ir izstrādāt datorprogrammas, kas spēj radīt cilvēkiem uztveramu tekstu. Starp automātiski ģenerētajiem teksta veidiem var atrast pat dažādas laika prognozes, biogrāfijas, kā arī tekstus, kas ietver sevī radošumu – dažādus stāstus, jokus vai dzeju. Automātiskā dzejas ģenerēšana ir šķietami sarežģīts uzdevums un ļ…
Dabiskās Valodas Dziļo Neironu Tīklu Ģeneratora GPT-2 Sniegums Latviešu un Angļu Valodā
2021
Darbs ir veltīts dabiskās valodas apstrādes tēmas un modeļa GPT-2 izpētei un tā snieguma novērtēšanai angļu valodā, kā arī pielāgota valodas modeļa realizēšanai un apmācībai tekstu ģenerēšanai arī latviešu valodā. GPT-2 ir liels dabiskās valodas apstrādes modelis, kas ir paplašināts no GPT modeļa, daudzkārt palielinot modeļa parametru skaitu un apmācot to uz vairāk treniņa datiem. GPT-2 modeļa apmācībai izmantots valodas korpuss no interneta mājaslapu tekstiem, atšķirībā no GPT modeļa, kura apmācībai izmantots valodas korpuss no grāmatu tekstiem. Šis modelis ir radīts ar mērķi paredzēt nākamo vārdu, ņemot vērā iepriekš esošos vārdus konkrētā tekstā. Apstrādājot iepriekš dotu tekstu, ar GPT-…
Familial combined hypolipidemia due to mutations in the ANGPTL3 gene
2013
The role of ANGPTL3 in lipoprotein metabolism emerged from studies in a mutant mouse strain characterized by severe hypotriglyceridemia and carrying a loss-of-function (LOF) mutation of the ANGPTL3 gene. ANGPTL3 was found to inhibit lipoprotein lipase and endothelial lipase. Genome-wide association studies in humans demonstrated the association of ANGPTL3 variants with plasma triglyceride levels and LOF mutations of ANGPTL3 were found in hypotriglyceridemic subjects in population studies. Recently, individuals originally classified as affected by familial hypobetalipoproteinemia were found to be homozygotes/compound heterozygotes for rare LOF mutations of ANGPTL3. They show a striking reduc…
In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats
2019
Graphical abstract