Search results for "GRAS"

New insights into the pharmacology of the short-chain free fatty acid receptors 2 and 3

2011

Metabolic diseases, such as diabetes, dyslipidemia or obesity, are more and more weighing on public health expenses in developed countries. Despite active research, these widespread diseases remain difficult to handle. Promising new therapeutic strategies against metabolic diseases include the development of drugs targeting the free fatty acid receptors, as key players in metabolism homeostasis. In this context, the current PhD thesis focuses on the study of two G protein-coupled receptors, namely the short-chain free fatty acid receptors 2 (FFA2) and 3 (FFA3). First, we investigated the expression of the two receptors of interest in a variety of cell types. Then, in order to study the phar…

Is the improvement of the nutritional quality compatible with the maintenance of the sensory quality? : the example of biscuits

2013

French biscuit producers are willing to improve the nutritional composition of their products. The. objective of this work was to determine whether it was possible while maintaining the sensory. quality of the reduced product. The first study dealt with the impact of fat and sugar reduction on liking and sensory perception of. 9 types of biscuits and cakes. Results show that children perceived almost no difference and liked. equally the standard and the fat- and/or sugar-reduced variants for most types of biscuits. For. products reduced without adding polyols, adults less like fat- or sugar-reduced variants than. standard ones mainly when they were perceived as less sweet, and to a lesser e…

L'amélioration de la qualité nutritionnelle est-elle compatible avec le maintien de la qualité sensorielle ? : l'exemple des biscuits

2013

French biscuit producers are willing to improve the nutritional composition of their products. The objective of this work was to determine whether it was possible while maintaining the sensory quality of the reduced product.The first study dealt with the impact of fat and sugar reduction on liking and sensory perception of 9 types of biscuits and cakes. Results show that children perceived almost no difference and liked equally the standard and the fat- and/or sugar-reduced variants for most types of biscuits. For products reduced without adding polyols, adults less liked fat- or sugar-reduced variants than standard ones mainly when they were perceived as less sweet, and to a lesser extent …

Cellular metabolic alteration : the voice of monoinsaturated fatty acid as therapeutic target

2010

Stearoyl Co-A desaturase (SCD) is the key enzyme of the metabolism of mono-unsaturated fatty acids (MUFA). Its activity  9 desaturase introduces a double bond cis in position 9 of saturated fatty acids (SFA), induced formation of MUFA. Impaired biosynthesis of MUFA is involved in many diseases such as cancer and cardiovascular disease. Cancer cells have a de novo synthesis of fatty acids increased with an accumulation MUFA. This change in the metabolism of fatty acids is associated with overexpression SCD1 which catalyzes the conversion of saturated fatty acids, monounsaturated fat. Several reports have shown that inhibition of SCD1 leads to blockage of proliferation and induction of apopt…

Réponses comportementales et préférences envers les acides gras à longue chaîne chez Drosophila melanogaster

2011

Fatty-acids (FAs) are crucial for animal survival and reproduction since these molecules are involved in many metabolic pathways and constitute a substantial store of energy. Despite the strong relationship established between excessive FA consumption and severe human etiologies (obesity, cancer, vascular diseases), our knowledge of the mechanisms underlying FA perception and preference is limited particularly in invertebrates. This is one of the reasons why we decided to investigate, during our PhD thesis, the perception of long-chain FAs (C14:0, C16:0, C18:0, C18:1, C18:2, C18:3), using the model species Drosophila melanogaster. We have also attempted to characterize some of the biologica…

Plasmalogen metabolism in retinal glial cells : interaction between cells during normal or pathological vascular development

2017

Retinal vascular disorders such as retinopathy of prematurity (ROP), diabetic retinopathy or age-related macular degeneration represent the first cause of vision loss at all ages in industrialized countries. Many epidemiological or animal studies have shown the involvement of polyunsaturated fatty acids (PUFA) in the regulation of vascular development and more specifically the beneficial properties of omega 3 PUFA (n-3 PUFA) against pathological vascularization. Those PUFA are esterified on glycerophospholipids (GP). GP are the primary constituents of the lipid bilayer of cell membranes. PUFA can be also esterified on a specific class of GP, called plasmalogens. Plasmalogens are characteriz…

Implication de la plasticité cérébrale hypothalamique dans la régulation de l'homéostasie énergétique chez la souris : effet d'un régime gras

2012

The hypothalamus plays a crucial role in the control of energy balance. In adult brain, this area remain plastic and the cellular network can be rapidly modified under environmental pressures. Studies show than hypothalamic remodeling are disturbed when metabolic diseases such as obesity or type II diabetes are declared. In this study we hypothesized that a high fat diet (HFD) inducing obesity could rapidly causes cell modifications in the adult hypothalamus network. To answer this question, we have established a one week HFD mouse model, and evaluated to type of hypothalamic plasticity which are synaptic plasticity and neurogenesis. Our results show that HFD leads to an increase of the exc…

Légumineuses et prairies temporaires : des fournitures d'azote pour les rotations

2015

Intervention présentée aux Journées de l'AFPF, "La fertilité des sols dans les systèmes fourragers", les 8 et 9 avril 2015; Les atouts des légumineuses (fixation symbiotique, diversité fonctionnelle...) leur permettent de contribuer à la fertilité des sols, à l'amélioration de la durabilité de l'agriculture et de l'autonomie protéique des systèmes alimentaires. Il convient donc de mieux connaître leurs rôles, directs et indirects, dans les flux d'azote des rotations.Les légumineuses fourragères (en culture pure ou dans des couverts multispécifiques) représentent une grande part des apports azotés symbiotiques. Il existe une grande diversité d'implication des légumineuses dans les rotations.…

Involvement of plasmalogens and polyunsaturated fatty acids in the pathogenesis of glaucoma

2013

Identification de gènes liés à la résistance aux herbicides non liée à la cible chez les Ivraies : vers des tests « moléculaires » de diagnostic

2016

Identification of genes linked to non-target-site resistance to herbicides in ryegrass : towards "molecular" diagnosis assays. Setting up molecular diagnosis tools would greatly foster preventing and managing non-target-sitebased resistance to herbicides (NTSR). This is currently hampered by the complexity of NTSR genetic determinism, which is largely based upon differences in the expression of an unknown number of genes between resistant and sensitive plants. Identifying NTSR genes is thus a challenging task. Herein, we report the identification of 19 genes which expression patterns are correlated to NTSR to ALS-inhibiting herbicides in rye-grasses (Lolium sp.). We demonstrate the potentia…