Search results for "GRI"
showing 10 items of 10209 documents
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
Agricultural feedstock for solid and liquid biofuel production in Ukraine: cluster analysis
2019
This study is focused on the cluster analysis of biofuel feedstock in Ukraine. In recent years, Ukraine has been facing energy issues. There was a drop in fossil fuel production. On other hand, there has been a rise in crop production. Therefore, one of Ukraine’s priorities is to develop energy application using agricultural feedstocks. The cluster analysis was used to distinguish regions by their feedstock potential. Feedstocks for solid biofuel, bioethanol, and biodiesel were investigated. Promising groups of regions for biofuel production were identified. The results can be used to create autonomous power supply systems based on agricultural by-products (straw and husk). The corn belt se…
Nanokristāliskā itrija oksīda lokālās struktūras pētījumi
2017
Darbā tiek pētīta nanokristāliskā (2 – 50 nm) itrija (III) oksīda (Y2O3) lokālā struktūra, izmantojot dažādas eksperimentālās (rentgenstaru difrakcijas, Ramana spektroskopijas, caurejošās elektronu mikroskopijas, rentgenabsorbcijas spektroskopijas) un teorētiskās (klasiskās molekulārās dinamikas (CMD) un apgrieztās Monte-Karlo (RMC)) metodes. Rentgenabsorbcijas spektri, kas satur informāciju par materiāla lokālo struktūru, tika iegūti izmantojot sinhrotrono starojumu. Iegūtie spektri tika interpretēti, veicot teorētiskos aprēķinus uz superdatora. Darbā tiek analizēti materiālu lokālo struktūru raksturojošie lielumi atkarībā no nanodaļiņu izmēra. Salīdzinot CMD un RMC iegūtos rezultātus, tie…
Gripas vīrusa hemaglutinīna fragmenta strukturāla izpēte un eksponēšana uz vīrusiem līdzīgo daļiņu virsmas
2015
Iekļaujot vakcīnā konservatīvus vīrusa proteīnu domēnus, būtu iespējams nodrošināt plaša spektra aizsardzību pret dažādiem gripas vīrusu apakštipiem. Viens no šādiem konservatīviem rajoniem ir hemaglutinīna (HA) stalka peptīds HA2.3. Bakalaura darba mērķis bija noteikt HA2.3 struktūru, tā eksponēšanas iespējas uz dažādu vīrusiem līdzīgo daļiņu (VLP) virsmas, un pētīt šo daļiņu imunoloģiskās īpašības. Pētījumā tika veikta HA2.3 ekspresija, attīrīšana, kristalizācija. Izmantojot rentgenstaru difrakciju, tika noteikts, ka HA2.3 struktūra vides pH 5,5 atbilst natīvajai HA stalka trimēra post fusion konformācijai. HA2.3 tika ķīmiski konjugēts pie dažādu VLP virsmas, kuras pēc tam izmantoja peļu …
Behaviours and Beliefs Related to Whistleblowing Against Doping in Sport: A Cross-National Study.
2022
BackgroundWhistleblowing has been recognized as an important deterrent of doping in elite competitive sport. The present study examined athletes’ knowledge of external whistleblowing channels and on how and where to report doping misconduct, perceived trust in different whistleblowing reporting channels, whistleblowing behaviour and athletes’ reasons for reporting (or not) doping misconduct.MethodsAthletes from Greece (n = 480), the Russian Federation (n = 512) and the United Kingdom (n = 171) completed a structured questionnaire on demographics, knowledge of different whistleblowing channels, perceived trust in internal and external whistleblowing channels, past whistleblowing behaviour an…
α2β1-integriinin ja stimuloidun epidermaalisen kasvutekijä-reseptorin reittien yhteydet
2011
Integriinien ja kasvutekijäreseptorien kulku solussa yhdistyy monimutkaisen vuorovaikutusten verkoston kautta. Ympäristön olosuhteista riippuvaisesti integriinit ja kasvutekijäreseptorit kantavat pääasiallisen vastuun solun selviytymisestä, kasvusta, erilaistumisesta, vaeltamisesta ja lisääntymisestä. Integriinit kiinnittävät solut alustaansa ja kasvutekijäreseptorit voivat vastata liukoisten ligandien haasteisiin. α2β1-integriinit reagoivat ligandeihinsa, joita voivat olla matriksimolekyylit, virukset ja keinotekoisesti myös vasta-aineet. Integriinien klusterointi viruksella tai vasta-aineilla aiheuttaa integriinin internalisaation endosomeihin, kun taas sitoutuminen matriksimolekyyleihin …
Life and economies in neo-Anthropocene: fruitful relationships between research, profession and local cooperation
2017
L’avvicinamento tra luoghi di produzione agricola e città, sempre più frequentemente, contribuisce alla progettazione di azioni coesive per riconfigurare il ciclo virtuoso della cattura della CO2 e della produzione di valori aggiunti “urbani”: diritti irrinunciabili, valore della vita, creatività. Questa tesi, in riferimento alla spinta progettuale ad un neo-Antropocene creativo (cfr. Ronsivalle 2016 e Carta, 2017), si può sostenere negli approcci teorici e metodologici e nella prassi dell’agricoltura urbana nelle sue varie forme. Tuttavia, solo nella costruzione di un quadro economico sostenibile, diventa possibile sviluppare un quadro ecologico utile alla riqualificazione dei sistemi urba…
The circular economy for resilience of the agricultural landscape and promotion of the sustainable agriculture and food systems
2022
The agricultural landscape is a public good to be preserved for long-term socio-economic and environmental effects. The agricultural landscape is preserved by the carrying out of agricultural activities. Through a empirical survey we examined how some young farmers in the countryside adopt conservation and resilience strategies. A common feature of the case studies examined is the adoption of photovoltaic energy production necessary for the performance of business activities. The method applied is that of the opportunity cost. The results of the research show that young farmers after graduation have returned to agriculture as they have an advantage in terms of opportunity costs compared to …
Between looking back and moving ahead : an exploration of the role of the body and its movement in a music therapy case study
2017
We exist in this world through our bodies. Every single experience is stored in it, it helps us to communicate with others, relate and build meaningful relationships. However, when the connection to our experiences or the control over our body is disrupted by a traumatic experience or disease, we become disconnected from our genuine self and the world around us. Music therapy provides us with a space for integration – of painful or joyful memories, emotions, and our bodies. Especially in Western cultures this physical relationship to music is often neglected, even though music and dance probably developed simultaneously and are still very much the same in some African cultures. When we are …
Conservation of traditional rural biotopes in Finland : a social-ecological approach
2018
This research focuses on conservation of traditional rural biotopes, which are biodiverse meadows and wood-pastures that are dependent on management through grazing or mowing. These low-intensity management actions have become rare as a result of agricultural modernisation. I have utilised a social-ecological approach in order to seek for the most critical factors hindering conservation of traditional rural biotopes in Finland. I also explore practical solutions that have the potential to improve their conservation status. The coverage of traditional rural biotopes has faced severe habitat loss during the last 150 years. This has led to endangerment of several habitat types and species that…